Letter: Effects of long-term plasmapheresis on plama proteins

Ja, Koepke; Kw, Wu; Jc, Hoak; Js, Thompson

doi:10.1046/j.1537-2995.1976.16276155119.x

Transfusion

1976

DOI: 10.1046/j.1537-2995.1976.16276155119.x

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Letter: Effects of long-term plasmapheresis on plama proteins

Koepke Ja¹,

Wu Kw²,

Hoak Jc³

et al.

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Cited by 6 publications

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A trial of immunotherapy in aplastic anemia and pure red cell aplasia

Young

Klein

Griffith

et al. 1983

J of Clinical Apheresis

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Immunotherapy, consisting of lymphocyte depletion or plasmapheresis in combination with cyclophosphamide and prednisone, was employed in three patients with refractory pure red cell aplasia and six patients with aplastic anemia of various etiologies. All three patients with pure red cell aplasia responded to plasmapheresis. One patient with atypical aplastic anemia showed partial recovery following lymphocyte depletion; the other five patients showed no evidence of a clinical response. The effect of patients' sera or bone marrow on formation of myeloid or erythroid colonies by bone marrow from normal individuals was determined in vitro. A decline in serum inhibition of erythroid colony formation was observed in the patients with pure red cell aplasia following treatment. Any changes in serum inhibition were less marked or unrelated to treatment outcome in the patients with aplastic anemia, although the single patient who responded to lymphocyte depletion exhibited reversal of coculture bone marrow inhibition. Our experience suggests that in vitro assay methods may not adequately predict the response of patients with aplastic anemia to this form of immunotherapy, and furthermore clinical improvement was too sporadic for this treatment to be recommended. Plasmapheresis may be a useful adjunct in patients with pure red cell aplasia, but remissions may not be dramatic or sustained.

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A trial of immunotherapy in aplastic anemia and pure red cell aplasia

Young

Klein

Griffith

et al. 1983

J of Clinical Apheresis

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Blood Donors, Paid or Unpaid?

Hamblin

1980

The Lancet

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The safety of weekly plateletpheresis: effect on the donors' lymphocyte population

et al. 1981

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Ten normal donors were monitored before, during, and after ten weekly donations of platelet concentrates prepared using the Haemonetics Model 30 blood processor. Analysis of these data indicates about a 20 per cent decrease of lymphocytes, with B cells being significantly decreased in half of these patients. While coincident immunoglobulin deficiencies did not develop in this short-term study, it is presumed that these would occur with a prolongation of platelet donations, as has been noted in previous studies. Additional studies are indicated to further delineate the lymphocyte depletion in normal platelet donors.

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Letter: Effects of long-term plasmapheresis on plama proteins

Cited by 6 publications

References 0 publications

A trial of immunotherapy in aplastic anemia and pure red cell aplasia

A trial of immunotherapy in aplastic anemia and pure red cell aplasia

Blood Donors, Paid or Unpaid?

The safety of weekly plateletpheresis: effect on the donors' lymphocyte population

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