LETM1 is a potential biomarker of prognosis in lung non-small cell carcinoma

Li, Piao; Yang, Zheng; Feng, Ying; Zhang, Chengye; Cui, Chunzhi; Xuan, Yanhua

doi:10.1186/s12885-019-6128-9

Cited by 16 publications

(14 citation statements)

References 23 publications

(26 reference statements)

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“…The disease is prone to metastasis and poor prognosis [18]. At present, many prognostic markers have been found, but the clinical application is less [19][20][21]. In this study, we con rmed that the expression of circ_0048856 in serum of NSCLC was increased, and the expression of circ_0048856 can be used as an independent prognostic biomarker for the overall survival rate of NSCLC patients, and it can also play a role by targeting miR-1287-5p.…”

Section: Discussionsupporting

confidence: 50%

Boosting Influences From circ_0048856 On Non-Small Cell Lung Cancer Advancement Via Aiming At miR-1287-5p

He¹,

Liu²,

Cha³

et al. 2021

Preprint

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Background: Non small cell lung cancer (NSCLC) is one of the main causes of death in human diseases. In this study, we aimed to explore the prognostic value of serum circ_0048856 in patients with NSCLC and its relationship with miR-1287-5p.Methods: The expression levels of circ_0048856 and miR-1287-5p in serum of NSCLC patients and healthy people were detected by qRT-PCR. The relationships between circ_0048856 expression and clinical data were evaluated via χ2 test. Overall survival analysis was carried out via Kaplan-Meier method with log rank test. Cox regression analysis was taken to evaluate the prognostic ability of circ_0048856 in NSCLC. Luciferase reporter gene was used to detect the targeting relationship between circ_0048856 and miR-1287-5p.Results: The expression of circ_0048856 in serum of NSCLC patients was significantly higher than that of healthy volunteers (P < 0.001). And its high expression was significantly correlated with TNM stage (P = 0.002) and lymph node metastasis (P < 0.001). In addition, Kaplan Meier log rank test analysis showed that the overall survival of patients with high expression of circ_0048856 was significantly shorter than that of patients with low expression of circ_0048856 (log rank test, P = 0.002). Serum circ_0048856 expression is an independent prognostic biomarker in NSCLC patients. Furthermore, we found that miR-1287-5p is a direct downstream miRNA of circ_0048856 through luciferase reporter gene analysis, and there is a negative correlation between circ_0048856 and miR-1287-5p.Conclusion: Serum circ_0048856 is an independent prognostic biomarker in patients with NSCLC. Circ_0048856 can participate in the progression of NSCLC by targeting miR-1287-5p.

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Section: Discussionsupporting

confidence: 50%

Boosting Influences From circ_0048856 On Non-Small Cell Lung Cancer Advancement Via Aiming At miR-1287-5p

He¹,

Liu²,

Cha³

et al. 2021

Preprint

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“…LETM1-mediated regulation of mitochondrial biogenesis, metabolism, and cell survival signaling has provided impetus to investigate LETM1 activity in various human cancers ( Dimmer et al, 2008 ; Piao et al, 2009a ; Li et al, 2015 ). Multiple human malignancies, including breast, colon, esophagus, lung, ovary, rectum, stomach, and uterine cervix, report high LETM1-expression profile correlating with poor prognosis, low survival rates, upregulation of cancer stemness genes, and enhanced angiogenesis ( Piao et al, 2009a , 2019a , b , 2020 ; Li et al, 2015 , 2020 ; Wang et al, 2015 , 2020 ; Huang et al, 2017a ; Yang et al, 2018 ). In thyroid, prostate, ovarian, and gastric cancers, LETM1 overexpression is correlated with increased cell survival via enhanced Akt signaling ( Lee et al, 2016 ; Piao et al, 2020 ; Wang et al, 2020 ; Zhang et al, 2020 ).…”

Section: The Diversity Of Letm1-induced Pathophysiologymentioning

confidence: 99%

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling

et al. 2021

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Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca2+ handling is unresolved. Meanwhile, LETM1 has been associated with the regulation of fundamental cellular processes, such as development, cellular respiration and metabolism, and apoptosis. This mini-review summarizes the diversity of cellular functions impacted by LETM1 and highlights the multiple roles of LETM1 in health and disease.

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“…In addition, Kaplan-Meier survival curve analysis, univariate and multivariable CPH model were performed to validate the prognostic performance of discovery dataset. To further confirm the clinical relevance of the multigene combination, we compared the prognostication performance of the multigene combination with several well-established biomarkers [15][16][17][18][19][20][21][22][23][24][25][26] in terms of C-index. All statistical analyses were performed using the R 3.5.2 software, and P<0.05 was considered statistically significant.…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, there were several well-established biomarkers including (ALDH1A1 [17], CD117 [18], CELIAC1 [19], CX3CL1 [20], IFITM1 [21], ITGA2B [22], LETM1 [23], PHLPP2 [24], RRBP1 [25], and TMEM213 [26]) in lung adenocarcinoma. We calculated the C-indexes of our 4-gene signature and the well-established signatures mentioned above.…”

Section: Validation Of the Prognostic Performance Of The 4-gene Combimentioning

confidence: 99%

Development and validation of a 4-gene combination for the prognostication in lung adenocarcinoma patients

Yin

Zhao

et al. 2020

J. Cancer

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Objective: To identify a multi-gene prognostic factor in patients with lung adenocarcinoma (LUAD). Materials and methods Prognosis-related genes were screened in the TCGA-LUAD cohort. Then, patients in this cohort were randomly separated into training set and test set. Least absolute shrinkage and selection operator (LASSO) regression was performed to the penalized the Cox proportional hazards regression (CPH) model on the training set, and a prognostication combination based on the result of LASSO analysis was developed. By performing Kaplan-Meier curve analysis, univariate and multivariable CPH model on the overall survival (OS) as well as recurrence free survival (RFS), the prognostication performance of the multigene combination were evaluated. Moreover, we constructed a nomogram and performed decision curve analysis to evaluate the clinical application of the multigene combination. Results We obtained 99 prognosis-related genes and screened out a 4-gene combination (including CIDEC, ZFP3, DKK1, and USP4) according to the LASSO analysis. The results of survival analyses suggested that patients in the 4-gene combination low-risk group had better OS and RFS than those in the 4-gene combination high-risk group. The 4-gene mentioned was demonstrated to be independent prognostic factor of patients with LUAD in the training set(OS, HR=11.962, P<0.001; RFS, HR=9.281, P<0.001) and test set (OS, HR=5.377, P=0.003; RFS, HR=2.949, P=0.104). More importantly, its prognosis performance was well in the validation set (OS, HR=0.955, P=0.002; RFS, HR=1.042, P<0.001). Conclusions We introduced a 4-gene combination which could predict the survival of LUAD patients and might be an independent prognostic factor in LUAD.

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LETM1 is a potential biomarker of prognosis in lung non-small cell carcinoma

Cited by 16 publications

References 23 publications

Boosting Influences From circ_0048856 On Non-Small Cell Lung Cancer Advancement Via Aiming At miR-1287-5p

Boosting Influences From circ_0048856 On Non-Small Cell Lung Cancer Advancement Via Aiming At miR-1287-5p

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling

Development and validation of a 4-gene combination for the prognostication in lung adenocarcinoma patients

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