Lethal and sublethal toxicity of the industrial chemical epichlorohydrin on Rhinella arenarum (Anura, Bufonidae) embryos and larvae

Wolkowicz, Ianina Ruth Hutler; Aronzon, Carolina Mariel; Coll, Cristina Silvia Pérez

doi:10.1016/j.jhazmat.2013.10.018

Cited by 23 publications

(12 citation statements)

References 39 publications

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“…Narcosis is an interesting effect with potential ecotoxicological consequences that might be brought about by numerous structurally unrelated chemicals in relation to their high octanol–water partition coefficients . Bisphenol A and epichlorohydrin, chemicals used to synthesize the BADGE epoxy resin can also cause induced narcosis on R. arenarum larvae .…”

Section: Discussionmentioning

confidence: 99%

Developmental toxicity of bisphenol A diglycidyl ether (epoxide resin badge) during the early life cycle of a native amphibian species

Wolkowicz

Svartz

Aronzon

et al. 2016

Enviro Toxic and Chemistry

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Bisphenol A diglycidyl ether (BADGE) is used in packaging materials, in epoxy adhesives, and as an additive for plastics, but it is also a potential industrial wastewater contaminant. The aim of the present study was to evaluate the adverse effects of BADGE on Rhinella arenarum by means of standardized bioassays at embryo-larval development. The results showed that BADGE was more toxic to embryos than to larvae at all exposure times. At acute exposure, lethality rates of embryos exposed to concentrations of 0.0005 mg/L BADGE and greater were significantly higher than rates in the vehicle control, whereas lethality rates of larvae were significantly higher in concentrations of 10 mg/L BADGE and greater. The toxicity then increased significantly, with 96-h median lethal concentrations (LC50s) of 0.13 mg/L and 6.9 mg/L BADGE for embryos and larvae, respectively. By the end of the chronic period, the 336-h LC50s were 0.04 mg/L and 2.2 mg/L BADGE for embryos and larvae, respectively. This differential sensitivity was also ascertained by the 24-h pulse exposure experiments, in which embryos showed a stage-dependent toxicity, with blastula being the most sensitive stage and S.23 the most resistant. The most important sublethal effects in embryos were cell dissociation and delayed development, whereas the main abnormalities observed in larvae related to neurotoxicity, as scare response to stimuli and narcotic effect. Environ Toxicol Chem 2016;35:3031-3038. © 2016 SETAC.

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Section: Discussionmentioning

confidence: 99%

Developmental toxicity of bisphenol A diglycidyl ether (epoxide resin badge) during the early life cycle of a native amphibian species

Wolkowicz

Svartz

Aronzon

et al. 2016

Enviro Toxic and Chemistry

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“…9 In addition, DGEBA, is obtained from BPA and epichlorhydrine which are considered as carcinogenic, mutagenic, reprotoxic and as endocrine disruptors. [10][11][12][13] Consequently, many researchers have been launched in order to obtain original non-toxic substitutes for epoxy resins in petro-compounds as well as in biobased derivatives. 8,14 A comprehensive review article that describes all kinds of reactants was reported by Chen et al 15 Actually, many issues have been highlighted on BPA, 16,17 that can form a close attachment to estrogen receptors 18 and affect body functions as cell regeneration, 19 embryo development, 20 and also induces hormone-dependent tumors that may result in prostate or breast cancers.…”

Section: Introductionmentioning

confidence: 99%

“…However, 10% were synthesized from renewable resources, , the overall production has reached almost 3 million tons per year . In addition, DGEBA is obtained from BPA and epichlorhydrine which are considered as carcinogenic, mutagenic, reprotoxic, and as endocrine disruptors. − Consequently, many researchers have been launched in order to obtain original nontoxic substitutes for epoxy resins in petro-compounds as well as in biobased derivatives. , A comprehensive review article that describes all kinds of reactants was reported by Chen et al Actually, many issues have been highlighted on BPA, , that can form a close attachment to estrogen receptors and affect body functions as cell regeneration, embryo development, and also induces hormone-dependent tumors that may result in prostate or breast cancers . Thus, BPA containing substances have been prohibited in food packaging industries because of their leaching to the aliments, leading to human exposure to this harmful chemical .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Properties of Furan Derivatives for Epoxy Resins

Eid

Améduri

Boutevin

2021

ACS Sustainable Chem. Eng.

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The discovery of huge petroleum reserves in the 19th century was a golden opportunity that promoted the industrial revolution, by offering a wide variety of cheap raw materials and a reliable source of energy. This caused an unprecedented increase of commodity and production of specialty chemicals in order to fulfill the needs of the global markets. However, as the global warming and the environmental issues has become a hazardous and worried situation, researchers are looking for bio renewable monomers with low toxicity in order to produce more sustainable polymers. This policy was also applied to epoxy resin materials because of their high volume production in industry for a wide range of applications. This review highlights the recent advances in the preparation of diamines and diepoxy monomers for the synthesis of epoxy resins, mainly from 2-furfural, 5-(hydroxymethyl)furfural (5-HMF), and 2,5-furandicarboxylic acid (FDCA), obtained from natural cellulose and hemicellulose feedstocks, respectively, and able to replace phthalic moieties in polyethylene terephthalate. In addition, the processes involved in the monomers preparation, such as reductive amination, etherification, esterification and carbonatation are listed. This review, reporting quasi-exhaustive synthetic pathways of epoxy precursors containing furanic moieties and describing the resulting resins, is composed of seven main parts, based on the synthesis of glycidyl derivatives containing one or two or four furan nuclei bearing or not a spacer between the furan ring and the function. The influence of the substituents on furan moieties (O, CO, CH 2 ) and the spacer between these groups have also been evaluated. Finally, thermal and a few mechanical properties of the obtained bio-sourced epoxy resins were compared to their fossil fuel analogues (from bisphenol A), featuring the high potential of bio-based monomers as substituents for non-renewable ones.

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“…AMPHITOX is a set of toxicity tests that employs embryos and larvae of R. arenarum providing information on mortality, malformations, delayed development, decreased growth, and behavioral abnormalities (Herkovits et al 2002;Herkovits and Pérez-Coll 2003;Hutler Wolkowicz et al 2013;Svartz et al 2012). Moreover, AMPHITOX allows evaluation of the uptake of a chemical (Pérez-Coll et al 1999;Herkovits and Pérez-Coll 2007;Pérez-Coll et al 2008;Aronzon et al 2014) as the assessment of stage-dependent susceptibility (Pérez-Coll and Herkovits 1990;Herkovits and Pérez-Coll 1993;Brodeur et al 2009;Svartz et al 2014) and expands the evaluation time, which allows obtaining acute, short-term chronic, and chronic toxicity results.…”

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confidence: 99%

Differential Uptake of Endosulfan in the South American Toad Under Sublethal Exposure

Svartz

Marino

Ronco

et al. 2015

Arch Environ Contam Toxicol

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Agroecosystems are usually polluted with a wide variety of contaminants with pesticides being very frequently detected. Endosulfan, an organochlorine pesticide, has been shown to cause both lethal and sublethal effects on aquatic organisms such as amphibians and especially on its early developmental stages. In this context, the aim of this study was to evaluate the uptake of environmentally relevant concentrations of endosulfan and its correlation with differential sensitivity in the early development stages of the common South American toad, Rhinella arenarum. Embryos and larvae were exposed to sublethal concentrations of endosulfan for several periods of exposures. According to the developmental stage at which they were exposed, the uptake rate was different. Bioconcentration factors (BCFs) for embryos significantly decreased with exposure time and concentration (p < 0.05) reaching a BCF of ≤1679 for embryos at 96 h of exposure to 0.001 mg endosulfan L(-1). BCFs for larvae significantly increased with exposure time (p < 0.05) obtaining a maximum of 40 at 504 h. In our previous study, we reported that embryos were less sensitive to the effects of endosulfan than larvae, which is in line with the main tendency of embryos to bioconcentrate endosulfan as observed in this study.

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Lethal and sublethal toxicity of the industrial chemical epichlorohydrin on Rhinella arenarum (Anura, Bufonidae) embryos and larvae

Cited by 23 publications

References 39 publications

Developmental toxicity of bisphenol A diglycidyl ether (epoxide resin badge) during the early life cycle of a native amphibian species

Developmental toxicity of bisphenol A diglycidyl ether (epoxide resin badge) during the early life cycle of a native amphibian species

Synthesis and Properties of Furan Derivatives for Epoxy Resins

Differential Uptake of Endosulfan in the South American Toad Under Sublethal Exposure

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