Lethal and sublethal toxicity of 4-nonylphenol to the common mussel (Mytilus edulis L.)

Granmo, Åke; Ekelund, Rolf; Magnusson, Kerstin; Berggren, Martin

doi:10.1016/0269-7491(89)90100-0

Cited by 94 publications

(33 citation statements)

References 12 publications

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“…Nonylphenol was reported to have an estrogenic activity at a tissue concentration of 1 M in vitro, although the activity was 10 -6 times less than 17-estradiol (E2), the main natural estrogen, (Jobling and Sumpter, 1993). Substantial evidences have been demonstrated showing that nonylphenol causes various disorders of the male reproductive system, including reduced testicular size and sperm production in rainbow trout and other marine animals (Granmo et al, 1989;Ekelund et al, 1990). Moreover, in vitro experiments also revealed that it induced proliferation of the human breast cancer cell line (Verma and Goldin, 1998).…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin-linked alginate beads as supporting materials for Sphingomonas cloacae, a nonylphenol degrading bacteria

Pluemsab

Fukazawa

Furuike

et al. 2007

Bioresource Technology

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Calcium alginate beads covalently linked with -cyclodextrin (-CD-alginate beads) were prepared and examined for their ability to serve as a supporting matrix for bacterial degradation of nonylphenol, an endocrine disruptor. Column chromatographic experiment using -CD-alginate beads with diameter of 657 ± 82 m and with degree of CD substitution of 0.16 showed a strong affinity for nonylphenol adsorption. Although addition of -CD (2.7-27 mM) to the culture broth of Sphingomonas cloacae retarded nonylphenol degradation, the immobilized bacteria on the CD-alginate beads were effective for the degradation. Batch degradation tests using the immobilized bacteria on -CD-alginate-beads showed 46% nonylphenol recovery after 10-day incubation at 25 ± 2 °C, and the recovery reached to about 17% when wide and shallow incubation tubes were used to facilitate uptake of the viscous liquid of nonylphenol on the surface of the medium. Scanning electron microscopic photographs revealed that multiplicated bacteria was present both on the surface and inside the beads and the matrix of CD-alginate was stable and suitable during 10-day incubation.

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Section: Introductionmentioning

confidence: 99%

Cyclodextrin-linked alginate beads as supporting materials for Sphingomonas cloacae, a nonylphenol degrading bacteria

Pluemsab

Fukazawa

Furuike

et al. 2007

Bioresource Technology

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“…(µg l −" ) order, and is found in both sediment and surface water (Giger et al, 1984 ;Ahel & Giger, 1985 ;Brunner et al, 1988 ;Marcomini et al, 1990 ;Rudel et al, 1996 ;Isobe & Takada, 1998 ;Kojima & Watanabe, 1998). There is growing evidence that NP has a certain oestrogenic activity (Granmo et al, 1989 ;Ekelund et al, 1990 ;Soto et al, 1991 ;Ahel et al, 1993 ; Jobling & Sumpter, 1993 ;Gray & Metcalfe, 1997 ;Ren et al, 1997 ;Shurin & Dodson, 1997 ;Ashfield et al, 1998 ;Coldham et al, 1998 ;Sonnenschein & Soto, 1998 …”

Section: Introductionmentioning

confidence: 99%

Sphingomonas cloacae sp. nov., a nonylphenol-degrading bacterium isolated from wastewater of a sewage-treatment plant in Tokyo.

Fujii¹,

Urano²,

Ushio³

et al. 2001

International Journal of Systematic and Evolutionary Microbiology

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A nonylphenol-assimilating bacterium isolated at a sewage-treatment plant in Tokyo was studied phenotypically, genotypically and phylogenetically. Analysis of the 16S rDNA sequence, the GMC content of the DNA (63 mol %) and the isoprenoid quinone composition, as well as the presence of sphingoglycolipid and the whole-cell fatty acid profile, revealed that the isolate is a member of the genus Sphingomonas. However, the sequence similarity of the 16S rDNA with that of known Sphingomonas spp. was found to be at most 96 %, implying that the isolate is distinctive. Furthermore, the results of DNA-DNA hybridization experiments and its physiological characteristics clearly indicated that the isolate represents a new Sphingomonas species, for which the name Sphingomonas cloacae is proposed ; strain S-3 T (l JCM 10874 T l IAM 14885 T ) is the type strain.Keywords : Sphingomonas cloacae sp. nov., biodegradation, endocrine disrupter chemical, nonylphenol INTRODUCTIONNonylphenol (NP) is known as an important intermediate in the production of many kinds of commercial and industrial materials. Above all, NP is used in the production of nonylphenol polyethoxylate, a nonionic surfactant with many industrial applications. However, NP is also known as a ubiquitous pollutant in urban aquatic environments, with concentrations in the p.p.b. (µg l −" ) order, and is found in both sediment and surface water (Giger et al., 1984 ;Ahel & Giger, 1985 ;Brunner et al., 1988 ;Marcomini et al., 1990 ;Rudel et al., 1996 ;Isobe & Takada, 1998 ;Kojima & Watanabe, 1998). There is growing evidence that NP has a certain oestrogenic activity (Granmo et al., 1989 ;Ekelund et al., 1990 ;Soto et al., 1991 ;Ahel et al., 1993 ; Jobling & Sumpter, 1993 ;Gray & Metcalfe, 1997 ;Ren et al., 1997 ;Shurin & Dodson, 1997 ;Ashfield et al., 1998 ;Coldham et al., 1998 ;Sonnenschein & Soto, 1998 Abbreviation : NP, nonylphenol.The GenBank/DDBJ accession number for the 16S rDNA sequence of strain S-3 T is AB040739. et al., 2000) and have isolated a NPdegrading bacterium (K. Fujii and others, unpublished data), which has been designated strain S-3 T . This strain degraded 1000 p.p.m. NP, i.e. a 10 000-1 000 000-fold higher concentration than found in urban environments, almost completely within 10 d. Analysis of 16S rDNA partial sequences strongly suggested that the bacterium is a novel species of the genus Sphingomonas. Tokyo (FujiiTo precisely identify and phylogenetically place strain S-3 T , phenotypic characterization, analysis of isoprenoid quinone composition, fatty acid composition, polar lipid pattern and DNA GjC content, 16S rDNA sequencing and DNA-DNA hybridization were carried out. On the basis of our results we propose that S-3 T should be placed in a new species of the genus Sphingomonas, Sphingomonas cloacae. METHODS Chemicals* IFO, Institute for Fermentation, Osaka, Japan ; JCM, Japan Collection of Microorganisms, Saitama, Japan ; ATTC, American Type Culture Collection, Manassas, VA, USA ; DSM, Deutsche Sammlung von Mikroorganismen und Zellkulturen...

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“…Phytoestrogens are naturally occurring xenoestrogens produced by plants. Man-made xenoestrogens include the alkylphenols, nonylphenol and octylphenol, and bisphenol A; environmental exposure to these compounds has been reported to modify sexual development and reproductive function in amphibians (2,3), crustacea (4,5), and fish (6). In mammals, evidence is less clear, but there is widespread public concern that they may exert similar effects on human reproductive health and be involved in the initiation of some hormone-dependent cancers (7)(8)(9)(10)(11)(12)(13)(14).…”

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confidence: 99%

Sulfation of “Estrogenic” Alkylphenols and 17β-Estradiol by Human Platelet Phenol Sulfotransferases

Harris

Waring

Kirk

et al. 2000

Journal of Biological Chemistry

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We have investigated the ability of alkylphenols to act as substrates and/or inhibitors of phenol sulfotransferase enzymes in human platelet cytosolic fractions. Our results indicate: (i) straight chain alkylphenols do not interact with the monoamine-sulfating phenol sulfotransferase (SULT1A3); (ii) short chain 4-n-alkylphenols (C < 8) are substrates for the phenol-sulfating enzymes (SULT1A1/2), which exhibit two activity maxima against substrates with alkyl chain lengths of C1-2 and C4 -5; (iii) long chain 4-n-substituted alkylphenols (C > 8) are poor substrates and act as inhibitors of SULT1A1/2; (iv) human platelets contain two activities, of low and high affinity, capable of sulfating 17␤-estradiol, and 4-n-nonylphenol is a partial mixed inhibitor of the low affinity form of this activity. We conclude that by acting either as substrates or inhibitors of SULT1A1/2, alkylphenols may influence the sulfation, and hence the excretion, of estrogens and other phenol sulfotransferase substrates in humans.

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Lethal and sublethal toxicity of 4-nonylphenol to the common mussel (Mytilus edulis L.)

Cited by 94 publications

References 12 publications

Cyclodextrin-linked alginate beads as supporting materials for Sphingomonas cloacae, a nonylphenol degrading bacteria

Cyclodextrin-linked alginate beads as supporting materials for Sphingomonas cloacae, a nonylphenol degrading bacteria

Sphingomonas cloacae sp. nov., a nonylphenol-degrading bacterium isolated from wastewater of a sewage-treatment plant in Tokyo.

Sulfation of “Estrogenic” Alkylphenols and 17β-Estradiol by Human Platelet Phenol Sulfotransferases

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