Let Sleeping Zebrafish Lie: A New Model for Sleep Studies

Jones, Rachel

doi:10.1371/journal.pbio.0050281

Cited by 11 publications

(7 citation statements)

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“…Sleep (sleep-like behavior): Activity characterized in zebrafish by rest behavior, including reversible immobility/ hypolocomotion, elevated arousal threshold, reduced respiratory rate (e.g., opercular movements) and mouth opening frequency, and a compensatory rebound in response to sleep deprivation. 107,122,144,145,[153][154][155][156] In adult zebrafish, includes brief periods of inactivity, often with a drooping caudal fin (see Droopy tail), alternated with active periods of swimming; can be easily reversed by startling stimuli, such as tapping, sound, or weak electric field. 1.149.…”

Section: Sink (Sinking)mentioning

confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

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Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish 'do', and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which collectively will contribute to better integration of biological data within and across species.

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Section: Sink (Sinking)mentioning

confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

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“…There is general agreement that sleep in teleosts differs from inactivity when the fish, even if only for seconds at a time, shows 1) behavioral quiescence, 2) increased arousal threshold, and 3) homeostatic control [5] [6] [7]. The first two criteria are met in the case presented here.…”

Section: Characterization Of Sleepmentioning

confidence: 62%

Is the Shark Just Drifting, or Does It Take a Quick Nap?

Ritter¹

2020

OJAS

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It is unknown if resting sharks can sleep, which is also true for gliding ones.Here, a videotaped bull shark is presented that drifted in an uncontrolled manner for 120 seconds while sinking with 0.1 m/second. Several aspects are discussed to determine if the shown behavior reflects the commonly accepted definition of sleep. Additionally, the idea is also discussed if this state might reflect a "quiet waking state" instead of where the shark still maintained some vigilance despite its general appearance.

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“…9 Zebrafish has been shown to be similar to mammalian biological models when it comes to toxicity tolerance and circadian rhythms. 10 Nevertheless, they are capable of regenerating several tissues, like fins, 11 heart, 2 photoreceptor cells and retinal neurons, 12 and even spinal cord. 13 Furthermore, several studies have been made over the years in development and differentiation of the nervous system in zebrafish, allowing for the mapping of their brain networks 14 which will facilitate the study of human neurological diseases.…”

Section: Introductionmentioning

confidence: 99%

The Importance of Zebrafish in Biomedical Research

Tavares

Lopes

2013

Acta Med Port

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Introduction: Zebrafish (Danio rerio) is an ideal model organism for the study of vertebrate development. This is due to the large clutches that each couple produces, with up to 200 embryos every 7 days, and to the fact that the embryos and larvae are small, transparent and undergo rapid external development.Material and Methods: Using scientific literature research tools available online and the keywords Zebrafish, biomedical research, human disease, and drug screening, we reviewed original studies and reviews indexed in PubMed.Results: In this review we summarized work conducted with this model for the advancement of our knowledge related to several human diseases. We also focused on the biomedical research being performed in Portugal with the zebrafish model.Discussion: Powerful live imaging and genetic tools are currently available for zebrafish making it a valuable model in biomedicalresearch. The combination of these properties with the optimization of automated systems for drug screening has transformed the zebrafish into a “top model” in biomedical research, drug discovery and toxicity testing. Furthermore, with the optimization of xenografts technology it will be possible to use zebrafish to aide in the choice of the best therapy for each patient.Conclusion: Zebrafish is an excellent model organism in biomedical research, drug development and in clinical therapy.

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Let Sleeping Zebrafish Lie: A New Model for Sleep Studies

Cited by 11 publications

References 0 publications

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

Is the Shark Just Drifting, or Does It Take a Quick Nap?

The Importance of Zebrafish in Biomedical Research

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