Less Polar Compounds and Targeted Antioxidant Potential (In Vitro and In Vivo) of Codium adhaerens C. Agardh 1822

Radman, Sanja; Cikoš, Ana-Marija; Flanjak, Ivana; Babić, Sanja; Čižmek, Lara; Šubarić, Drago; Čož‐Rakovac, Rozelindra; Jokić, Stela; Jerković, Igor

doi:10.3390/ph14090944

Cited by 14 publications

(20 citation statements)

References 54 publications

(89 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sub-group containing 55 carbon atoms (with the aliphatic side chain) was represented with five compounds (entries 10, 11, 12, 19 and 20, Tables 1 and 2). In contrast to Codium adhaerens [42], the subgroup with 35 carbon atoms (without the aliphatic side chain) was not present. Pheopthyin b (entry 19, Tables 1 and 2) was more abundant in E. crinita, particularly in F4 of FdEc, while pheophytin a (entry 20, Tables 1 and 2) was more abundant in F4 of FdEa.…”

Section: Resultsmentioning

confidence: 72%

“…Triterpenes β-stigmasterol (entry 16, Tables 1 and 2) and structurally related sterol (3β,6α)-14-methylergosta-8,24(28)-diene-3,6-diol (entry 17, Tables 1 and 2) were present in F3 and F4 of both algae. Previously, they were found in C. adhaerens [42] and F. virsoides [31].…”

Section: Resultsmentioning

confidence: 91%

“…or C. adhaerens [42], as well as brown algae Sargassum fulvellum [44] or F. virsoides [31]. The other three compounds of this subgroup were pheophytin a derivatives characterized by the presence of an additional double bond, carbonyl or hydroxyl group in their composition (entries 10, 11 and 12, Tables 1 and 2).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity

et al. 2022

Self Cite

View full text Add to dashboard Cite

Ericaria crinita and Ericaria amentacea from the Adriatic Sea (Croatia) were investigated with respect to the presence of less-polar compounds for the first time after fractionation by solid-phase extraction (SPE). The composition of less-polar fractions of freeze-dried E. crinita (FdEc) and E. amentacea (FdEa) were analyzed by high-performance liquid chromatography–high-resolution mass spectrometry with electrospray ionization (UHPLC-ESI-HRMS). The major identified compounds were: amides of higher aliphatic acids (palmitoleamide, linoleamide, palmitamide, oleamide and erucamide) and related compounds, carotenoid (fucoxanthin), chlorophyll derivatives (pheophytin a and b and their derivatives) and higher terpenes (loliolide, isoamijiol with its oxidation product), β-stigmasterol and (3β,6α)-14-methylergosta-8,24(28)-diene-3,6-diol). The toxic effects observed on the less-polar fractions obtained from Ericaria species on zebrafish Danio rerio embryos could be associated with the high abundance of all five detected amides. The antioxidant activity of the fractions was evaluated by means of five independent assays, including the reduction of the radical cation (ABTS), the oxygen radical absorbance capacity (ORAC), ferric-reducing antioxidant power (FRAP), the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay and the Folin–Ciocalteu method. A higher antioxidant activity of E. amentacea in comparison to that of the E. crinita fractions was found with IC50 concentrations of 0.072 and 1.177 mg/mL, respectively. The correlation between the activity and the chemical composition revealed that the synergistic effect of different compounds impacted their antioxidant response.

show abstract

Section: Resultsmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 91%

See 1 more Smart Citation

Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…α-Isophorone (4) is commonly found in the essential oils of diverse plants [57][58][59][60][61] and also in the essential oil of U. lactuca [54]. Its hydroxy-derivative 2-hydroxyisophorone (6) was reported from the hydrodistillate of the air-dried green alga Codium adhaerens [62]. 2-Hydroxy-4,4,6-trimethylcyclohexa-2,5-dien-1-one (7) has not been reported from algae so far.…”

Section: Apocarotenoidsmentioning

confidence: 99%

Identification of Volatiles of the Dinoflagellate Prorocentrum cordatum

et al. 2022

View full text Add to dashboard Cite

The dinoflagellate Prorocentrum cordatum, often called P. minimum, is a potentially toxic alga found in algal blooms. Volatile compounds released by the alga might carry important information, e.g., on its physiological state, and may act as chemical messengers. We report here the identification of volatile organic compounds emitted by two strains, xenic P. cordatum CCMP 1529 and axenic P. cordatum CCMP 1329. The volatiles released during culture were identified despite their low production rates, using sensitive methods such as open-system-stripping analysis (OSSA) on Tenax TA desorption tubes, thermodesorption, cryofocusing and GC/MS-analysis. The analyses revealed 16 compounds released from the xenic strain and 52 compounds from the axenic strain. The majority of compounds were apocarotenoids, aromatic compounds and small oxylipins, but new natural products such as 3,7-dimethyl-4-octanolide were also identified and synthesized. The large difference of compound composition between xenic and axenic algae will be discussed.

show abstract

“…In addition, phytosterols, especially fucosterol, also seem to have health benefits, including anticancer, antidiabetic, immunomodulatory, anti-obesity, anti-inflammatory, neuroprotective, and many others [22]. Finally, pigments derived from various macroalgae are shown to have antioxidant activities using in vitro and in vivo assays [23][24][25].…”

Section: Introduction 1algae As a Source Of Bioactive Molecules For H...mentioning

confidence: 99%

Biotechnological Enhancement of Probiotics through Co-Cultivation with Algae: Future or a Trend?

et al. 2022

Self Cite

View full text Add to dashboard Cite

The diversity of algal species is a rich source of many different bioactive metabolites. The compounds extracted from algal biomass have various beneficial effects on health. Recently, co-culture systems between microalgae and bacteria have emerged as an interesting solution that can reduce the high contamination risk associated with axenic cultures and, consequently, increase biomass yield and synthesis of active compounds. Probiotic microorganisms also have numerous positive effects on various aspects of health and represent potent co-culture partners. Most studies consider algae as prebiotics that serve as enhancers of probiotics performance. However, the extreme diversity of algal organisms and their ability to produce a plethora of metabolites are leading to new experimental designs in which these organisms are cultivated together to derive maximum benefit from their synergistic interactions. The future success of these studies depends on the precise experimental design of these complex systems. In the last decade, the development of high-throughput approaches has enabled a deeper understanding of global changes in response to interspecies interactions. Several studies have shown that the addition of algae, along with probiotics, can influence the microbiota, and improve gut health and overall yield in fish, shrimp, and mussels aquaculture. In the future, such findings can be further explored and implemented for use as dietary supplements for humans.

show abstract

Less Polar Compounds and Targeted Antioxidant Potential (In Vitro and In Vivo) of Codium adhaerens C. Agardh 1822

Cited by 14 publications

References 54 publications

Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity

Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity

Identification of Volatiles of the Dinoflagellate Prorocentrum cordatum

Biotechnological Enhancement of Probiotics through Co-Cultivation with Algae: Future or a Trend?

Contact Info

Product

Resources

About