Less correlation between mismatch repair proteins deficiency and decreased expression of HLA class I molecules in endometrial carcinoma: a different propensity from colorectal cancer

Mariya, Tasuku; Kubo, Terufumi; Hirohashi, Yoshihiko; Yanagawa, Junko; Tabuchi, Yuta; Matsuo, Keitaro; Furumura, Kiyoshi; Morita, Rena; Nakatsugawa, Munehide; Kanaseki, Takayuki; Tsukahara, Tomohide; Hasegawa, Tadashi; Saito, Tsuyoshi; Torigoe, Toshihiko

doi:10.1007/s00795-020-00254-6

Cited by 3 publications

(8 citation statements)

References 31 publications

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“…Representative studies showing the prognostic significance of HLA class I expression in tumors evaluated by immunohistochemistry using FFPE specimens are summarized in Table 1. [49][50][51] Many studies have concluded that the loss of HLA class I heavy chain expression is correlated with a worse prognosis, although some studies did not. It is likely that the discrepancy in the reported findings arises from the scope of cases examined.…”

Section: Significance Of Evaluating Hla Class I Molecules Expressed I...mentioning

confidence: 99%

“…Interestingly, unlike colorectal or gastric cancer, there is no comparable pattern observed between dMMR and expression of HLA class I in endometrial cancer. 49,119 Although cases with dMMR colorectal or gastric cancer have a good prognosis, it is still not known whether dMMR uterine cancer has a better prognosis. 49,120 In other words, immune surveillance in endometrial cancer may not be as active as observed in colorectal or gastric cancers.…”

Section: Significance Of Evaluating Hla Class I Molecules Expressed I...mentioning

confidence: 99%

“…For example, some reports classify the expression of HLA class I molecules into three or four levels based on staining intensity, while others focus on the localization of expression and classify HLA class I expression into membrane-anchored, cytoplasmically expressed, and loss of expression. [48][49][50] A method proposed as a candidate for integrated evaluation criteria involves multiplying staining intensity by staining proportion. 51 However, this method may not be perfect due to the diversity in staining intensity observed within the observed area.…”

Section: Assessment Of Hla Class I Expressionmentioning

confidence: 99%

“…49,119 Although cases with dMMR colorectal or gastric cancer have a good prognosis, it is still not known whether dMMR uterine cancer has a better prognosis. 49,120 In other words, immune surveillance in endometrial cancer may not be as active as observed in colorectal or gastric cancers. Therefore, even in cases of dMMR, there might not be a necessity to downregulate the expression of HLA class I to evade immune surveillance.…”

Section: Significance Of Evaluating Hla Class I Molecules Expressed I...mentioning

confidence: 99%

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Assessment of cancer cell‐expressed HLA class I molecules and their immunopathological implications

Kubo,

Asano,

Sasaki

et al. 2024

HLA

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Immunotherapy using immune checkpoint inhibitors (ICIs) has shown superior efficacy compared with conventional chemotherapy in certain cancer types, establishing immunotherapy as the fourth standard treatment alongside surgical intervention, chemotherapy, and radiotherapy. In cancer immunotherapy employing ICIs, CD8‐positive cytotoxic T lymphocytes are recognized as the primary effector cells. For effective clinical outcomes, it is essential that the targeted cancer cells express HLA class I molecules to present antigenic peptides derived from the tumor. However, cancer cells utilize various mechanisms to downregulate or lose HLA class I molecules from their surface, resulting in evasion from immune surveillance. Correlations between prognosis and the integrity of HLA class I molecules expressed by cancer cells have been consistently found across different types of cancer. This paper provides an overview of the regulatory mechanisms of HLA class I molecules and their role in cancer immunotherapy, with a particular emphasis on the significance of utilizing pathological tissues to evaluate HLA class I molecules expressed in cancer cells.

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Section: Significance Of Evaluating Hla Class I Molecules Expressed I...mentioning

confidence: 99%

Section: Significance Of Evaluating Hla Class I Molecules Expressed I...mentioning

confidence: 99%

Section: Assessment Of Hla Class I Expressionmentioning

confidence: 99%

Section: Significance Of Evaluating Hla Class I Molecules Expressed I...mentioning

confidence: 99%

See 2 more Smart Citations

Assessment of cancer cell‐expressed HLA class I molecules and their immunopathological implications

Kubo,

Asano,

Sasaki

et al. 2024

HLA

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show abstract

“…We name this phenomenon “adaptive immune escape”. However, surprisingly, in endometrial cancer, this tendency is not the case, potentially because of differences in the immune microenvironment between the two types of carcinoma ( 126 ).…”

Section: Predictive Markers Of Ici Efficacy By Histopathological Analysismentioning

confidence: 99%

Fundamental and Essential Knowledge for Pathologists Engaged in the Research and Practice of Immune Checkpoint Inhibitor-Based Cancer Immunotherapy

et al. 2021

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Extensive research over 100 years has demonstrated that tumors can be eliminated by the autologous immune system. Without doubt, immunotherapy is now a standard treatment along with surgery, chemotherapy, and radiotherapy; however, the field of cancer immunotherapy is continuing to develop. The current challenges for the use of immunotherapy are to enhance its clinical efficacy, reduce side effects, and develop predictive biomarkers. Given that histopathological analysis provides molecular and morphological information on humans in vivo, its importance will continue to grow. This review article outlines the basic knowledge that is essential for the research and daily practice of immune checkpoint inhibitor-based cancer immunotherapy from the perspective of histopathology.

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Application of Pelvic Magnetic Resonance Imaging Scan Combined with Serum Pyruvate Kinase Isozyme M2, Neutrophil Gelatinase‐Associated Lipocalin, and Soluble Leptin Receptor Detection in Diagnosing Endometrial Carcinoma

Yin

2022

Contrast Media & Molecular Imaging

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Objective. To explore the application value of pelvic magnetic resonance imaging (MRI) scan combined with serum pyruvate kinase isozyme M2 (PKM2), neutrophil gelatinase-associated lipocalin (NGAL), and soluble leptin receptor (sOB-R) detection in diagnosing endometrial carcinoma (EC). Methods. The clinical data of 45 patients with pathologically confirmed EC treated in our hospital from May 2019 to May 2020 were retrospectively analyzed. All patients received pelvic MRI scan, serum PKM2, NGAL and sOB-R detection was performed, and the combination of the two was performed so as to analyze the diagnostic application value of the three modalities. Results. Compared with the joint detection, the number of true positive cases, sensitivity, specificity, and accuracy rate obtained by a single application of pelvic MRI or serum PKM2, NGAL, and sOB-R detection were obviously lower; the area under the ROC curve of the joint detection was obviously larger than that of single detection; the results of the joint detection were better than those of single detection ( P < 0.05 ); the combined diagnosis obtained the highest sensitivity. Conclusion. Combining pelvic MRI with serum PKM2, NGAL, and sOB-4 detection can effectively promote the diagnostic accuracy for EC, presenting significant clinical diagnostic value.

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Less correlation between mismatch repair proteins deficiency and decreased expression of HLA class I molecules in endometrial carcinoma: a different propensity from colorectal cancer

Cited by 3 publications

References 31 publications

Assessment of cancer cell‐expressed HLA class I molecules and their immunopathological implications

Assessment of cancer cell‐expressed HLA class I molecules and their immunopathological implications

Fundamental and Essential Knowledge for Pathologists Engaged in the Research and Practice of Immune Checkpoint Inhibitor-Based Cancer Immunotherapy

Application of Pelvic Magnetic Resonance Imaging Scan Combined with Serum Pyruvate Kinase Isozyme M2, Neutrophil Gelatinase‐Associated Lipocalin, and Soluble Leptin Receptor Detection in Diagnosing Endometrial Carcinoma

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