Assessment of cancer cell‐expressed HLA class I molecules and their immunopathological implications
Terufumi Kubo,
Shiori Asano,
Kenta Sasaki
et al.
Abstract:Immunotherapy using immune checkpoint inhibitors (ICIs) has shown superior efficacy compared with conventional chemotherapy in certain cancer types, establishing immunotherapy as the fourth standard treatment alongside surgical intervention, chemotherapy, and radiotherapy. In cancer immunotherapy employing ICIs, CD8‐positive cytotoxic T lymphocytes are recognized as the primary effector cells. For effective clinical outcomes, it is essential that the targeted cancer cells express HLA class I molecules to prese… Show more
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