Lesions suggérant une réactivité auto-immune ches les souris alteintes de la “runt disease” après thymectomie néonatale

DeVries, M. J.; Putten, L.M. van; Balner, H.; Bekkum, D. W. van

doi:10.1097/00007890-196505000-00017

Cited by 14 publications

(21 citation statements)

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“…(46) previously demonstrated that Coombs positivity and other 'autoimmune' phenomena are frequently seen in rabbits after neonatal removal of the thymus or after later removal of the thymus and appendix, together with total body irradiation. Similar abnormalities have often been observed in mice subjected to neo natal thymus removal (21,82) and in patients with immune de ficiency disorders (7,27,31,67,69,76).…”

Section: Table IVsupporting

confidence: 68%

Production of an Antibody Deficiency Syndrome in Rabbits by Neonatal Removal of Organized Intestinal Lymphoid Tissues

Cooper

Perey

Gabrielsen

et al. 1968

Int Arch Allergy Immunol

101

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Section: Table IVsupporting

confidence: 68%

Production of an Antibody Deficiency Syndrome in Rabbits by Neonatal Removal of Organized Intestinal Lymphoid Tissues

Cooper

Perey

Gabrielsen

et al. 1968

Int Arch Allergy Immunol

101

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“…In mice, for example, ranting and wasting, anemia, and amyloid accumulation are seen in parabiotic intoxication and graft versus host reactions (sec 10 and 21; 13, 76). Coombs positivity has been found in mice and other species with immunologic runt disease (48,57,64) and has been observed by de V ries et al (19,20) in neonatally thymectomizcd mice of certain strains. The latter also develop a wasting syndrome, and have lupus erythematosuslike lesions in kidney and heart, and L. E. rosettes in some instances.…”

Section: Discussionmentioning

confidence: 78%

Wasting Disease, Coombs-Positivity, and Amyloidosis in Rabbits Subjected to Central Lymphoid Tissue Extirpation and Irradiation

Kellum¹,

Sutherland²,

Eckert³

et al. 1965

Int Arch Allergy Immunol

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“…It is important that the lymphoid cells administered be cells incapable of destructive graft versus host assault on the thymectomized host. If, as deVries et al (23,24) have suggested, the runting and wasting of neonatally thymectomized mice is a consequence of an autoimmune process, this destructive process is reversible simply by providing the neonatally thymectomized host with a lymphoid cell population capable of repopulating the peripheral lymphoid organs.…”

Section: Discussionmentioning

confidence: 99%

Studies on Immunologic Reconstitution of Thymectomized Mice

Yunis

Hilgard

Martínez

et al. 1965

The Journal of Experimental Medicine

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1. Immunologic function, growth, and longevity of neonatally thymectomized mice was restored by intraperitoneal administration of 100 to 400 million syngeneic, hemiallogeneic, or ailogeneic thymus cells from newborn or adult donors. Assays of the graft versus host capabilities of spleen cells from the animals restored with allogeneic cells showed that their immunologically competent cells are of donor histocompatibility characteristics. Such animals accepted skin grafts from mice of the cell donor strain, but rejected skin from a third strain. 2. Similar results were obtained when the neonatally thymectomized animals were treated with 10 to 100 million syngeneic, hemiallogeneic, or allogeneic cells from adult spleen. 3. In one strain combination, C3H recipients and A donors, injected thymus or spleen cells apparently attacked host tissues, since the animals died very early of wasting disease. When this combination was reversed, A strain recipients treated with C3H cells were reconstituted immunologically and physiologically. 4. Syngeneic or allogeneic adult spleen, grafted in the newborn period, reconstituted neonatally thymectomized mice, but all experiments involving grafting of newborn spleen failed. Immunogenetic analysis of the host spleen cells from two allogeneic spleen-grafted animals previously thymectomized showed that the reconstitution was entirely of donor histocompatibility characteristics. 5. Postthymectomy wasting disease was reversed by administration of 200 million adult syngeneic spleen or thymus cells. Immunologic recovery was confirmed by graft versus host assays of the spleens of the recovered animals and by application of allogeneic skin grafts. Some of the animals have been under observation for 42 weeks and appear to be normal. 6. The wasting syndrome in neonatally thymectomized mice was also reversed by injection of 200 million hemiallogeneic or allogeneic spleen cells. 7. Thymus grafts did not reverse wasting disease, whether the donors were adult or newborn, of the same strain or a different one. 8. Spleen, lymph node, and Peyer's patches from representative animals of the reconstituted groups were examined and compared with the tissues of untreated neonatally thymectomized mice and intact animals of the same strain. Tissues of normal cellularity and follicular organization were found in some of the reconstituted animals and also in mice with reversed wasting disease. Extreme deficit of the lymphoid tissues was rare in either group.

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Lesions suggérant une réactivité auto-immune ches les souris alteintes de la “runt disease” après thymectomie néonatale

Cited by 14 publications

References 0 publications

Production of an Antibody Deficiency Syndrome in Rabbits by Neonatal Removal of Organized Intestinal Lymphoid Tissues

Production of an Antibody Deficiency Syndrome in Rabbits by Neonatal Removal of Organized Intestinal Lymphoid Tissues

Wasting Disease, Coombs-Positivity, and Amyloidosis in Rabbits Subjected to Central Lymphoid Tissue Extirpation and Irradiation

Studies on Immunologic Reconstitution of Thymectomized Mice

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