Wasting Disease, Coombs-Positivity, and Amyloidosis in Rabbits Subjected to Central Lymphoid Tissue Extirpation and Irradiation

Kellum, Michael J.; Sutherland, David E.R.; Eckert, Elke D.; Peterson, Reece L.; Good, Robert A.

doi:10.1159/000229594

Cited by 31 publications

(15 citation statements)

References 35 publications

(39 reference statements)

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“…Rabbits subjected to neonatal removal of the appendix in these experiments, as in prior studies (46,73), showed a significant increase in incidence of Coombs positive red blood cells. This accentuation of an 'autoimmune' process was almost doubled when early removal ofsacculus and Peyer's patches was added to removal ofthe appendix.…”

Section: Discussionsupporting

confidence: 69%

“…(73) and K ellum el al. (46) previously demonstrated that Coombs positivity and other 'autoimmune' phenomena are frequently seen in rabbits after neonatal removal of the thymus or after later removal of the thymus and appendix, together with total body irradiation. Similar abnormalities have often been observed in mice subjected to neo natal thymus removal (21,82) and in patients with immune de ficiency disorders (7,27,31,67,69,76).…”

Section: Table IVmentioning

confidence: 99%

See 1 more Smart Citation

Production of an Antibody Deficiency Syndrome in Rabbits by Neonatal Removal of Organized Intestinal Lymphoid Tissues

Cooper

Perey

Gabrielsen

et al. 1968

Int Arch Allergy Immunol

101

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Section: Discussionsupporting

confidence: 69%

Section: Table IVmentioning

confidence: 99%

Production of an Antibody Deficiency Syndrome in Rabbits by Neonatal Removal of Organized Intestinal Lymphoid Tissues

Cooper

Perey

Gabrielsen

et al. 1968

Int Arch Allergy Immunol

101

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“…Mammals have no bursa. Nevertheless, extirpation experiments in the rabbit (28), and the study of patients with defects in immunological performance (29) suggest that the vermiform appendix, tonsils, and possibly other, gut-associated, lymphoid organs have a bursal role. The only alternative is that follicular lymphocytes and those in thymus-dependent areas are members of the same cell population at a different stage in development.…”

Section: Discussionmentioning

confidence: 99%

Migration of Lymphocytes and Thymocytes in the Rat

Goldschneider

McGregor

1968

The Journal of Experimental Medicine

148

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The cellular deficit in rats thymectomized at birth is primarily one of circulating small lymphocytes. The lymphocyte deficiency is similar to that induced in adult rats by chronic drainage from a thoracic duct fistula. In both cases, the animals show a reduction of small lymphocytes in peripheral blood, thoracic duct lymph, and in circumscribed areas of lymphoid tissue. The lympocyte deficiency in lymphoid tissue can be corrected by an intravenous injection of thoracic duct lymphocytes. The evidence suggests that the deficiency is corrected by small lymphocytes. Small lymphocytes pass from blood to lymphoid tissue along a route which includes the marginal sinus in splenic white pulp and postcapillary venules in the cortex of lymph nodes and Peyer's patches. Neither the ability of small lymphocytes to colonize lymphoid tissue nor their ability to traverse postcapillary venules are thymus-dependent phenomena. However, movement of small lymphocytes across postcapillary venules appears to modify the structure of endothelium. Intravenously injected small thymocytes migrate to lymphoid tissue in smaller numbers than small lymphocytes inoculated by the same route. The few thymocytes which localize in lymphoid tissue follow the same pathway as circulating small lymphocytes.

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“…In mice and rabbits thymectomized at birth (D0Tx) this lymphopenia is frequently associated with a wasting disease characterized by weight loss, lethargy, ruffled fur, hunched posture, periorbital edema, skin lesions, diarrhea, and death (1). Histologically, multiorgan inflammation involving the kidney, liver, and heart as well as ulcerative colitis and anemia are seen (3)(4)(5)(6).…”

mentioning

confidence: 99%

“…Both D0Tx mice and rabbits, however, exhibit autoimmune phenomenon, including Coombs'-positive erythrocytes, antinuclear Abs, and lupus-like symptoms, including kidney disease (3)(4)(5)(6)(7)(8)(9)(10). Additionally, thymectomy on day 3 of life (D3Tx) leads to autoimmune disease of the prostate (11), testes and epididymis (12,13), thyroid (14), stomach (13,15), lacrimal and salivary glands (16), and ovarian dysgenesis (AOD) (13,(17)(18)(19) with little or no wasting disease.…”

mentioning

confidence: 99%

Aod1Controlling Day 3 Thymectomy-Induced Autoimmune Ovarian Dysgenesis in Mice Encompasses Two Linked Quantitative Trait Loci with Opposing Allelic Effects on Disease Susceptibility

Roper

McAllister

Biggins

et al. 2003

The Journal of Immunology

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Day 3 thymectomy (D3Tx) leads to a paucity of CD4+CD25+ suppressor T cells, a loss of peripheral tolerance, and the development of organ-specific autoimmune disease in adult mice. Importantly, D3Tx does not lead to autoimmune disease in all mouse strains, indicating that this process is genetically controlled. Previously, we reported linkage of D3Tx-induced autoimmune ovarian dysgenesis (AOD) and its intermediate phenotypes, antiovarian autoantibody responsiveness, oophoritis, and atrophy, to five quantitative trait loci (QTL), designated Aod1 through Aod5. We also showed interaction between these QTL and H2 as well as Gasa2, a QTL controlling susceptibility to D3Tx-induced autoimmune gastritis. To physically map Aod1, interval-specific bidirectional recombinant congenic strains of mice were generated and studied for susceptibility to D3Tx-induced AOD. Congenic mapping studies revealed that Aod1 controls susceptibility to oophoritis and comprises two linked QTL with opposing allelic effects. Aod1a resides between D16Mit211 (23.3 cM) and D16Mit51 (66.75 cM) on chromosome 16. Aod1b maps proximal of Aod1a between D16Mit89 (20.9 cM) and D16Mit211 (23.3 cM) and includes the candidate genes stefin A1, A2, and A3 (Stfa1-Stfa3), inhibitors of cathepsin S, a cysteine protease required for autoantigen presentation, and the development of autoimmune disease of the salivary and lacrimal glands following D3Tx. cDNA sequencing revealed the existence of structural polymorphisms for both Stfa1 and Stfa2. Given the roles of cathepsins in Ag processing and presentation, Stfa1 and Stfa2 alleles have the potential to control susceptibility to autoimmune disease at the level of both CD4+CD25+ suppressor and CD4+CD25− effector T cells.

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Wasting Disease, Coombs-Positivity, and Amyloidosis in Rabbits Subjected to Central Lymphoid Tissue Extirpation and Irradiation

Cited by 31 publications

References 35 publications

Production of an Antibody Deficiency Syndrome in Rabbits by Neonatal Removal of Organized Intestinal Lymphoid Tissues

Production of an Antibody Deficiency Syndrome in Rabbits by Neonatal Removal of Organized Intestinal Lymphoid Tissues

Migration of Lymphocytes and Thymocytes in the Rat

Aod1Controlling Day 3 Thymectomy-Induced Autoimmune Ovarian Dysgenesis in Mice Encompasses Two Linked Quantitative Trait Loci with Opposing Allelic Effects on Disease Susceptibility

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