Lesion Localization of Time Disorientation in Patients With Focal Brain Damage

Skye, Jax; Bruss, Joel; Herbet, Guillaume; Tranel, Daniel; Boes, Aaron D.

doi:10.1101/2022.05.24.493338

Cited by 5 publications

(7 citation statements)

References 49 publications

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“…These results align with previous research finding a consistent role for medial parietal and medial temporal lobe structures in processing time and space ( Whitney et al. 2009 ; Cohn-Sheehy and Ranganath 2017 ; Skye et al. 2022 ).…”

Section: Resultssupporting

confidence: 92%

“…This adds to a growing body of work associating medial parietal regions, and particularly the precuneus, with temporal processing ( Peer et al. 2015 ; Cohn-Sheehy and Ranganath 2017 ; Skye et al. 2022 ).…”

Section: Discussionmentioning

confidence: 95%

“…2022 ). Using lesion-symptom mapping, Skye et al. (2022) pinpointed the precuneus as well as parahippocampal cortex (PHC) as crucially involved in time orientation.…”

Section: Discussionmentioning

confidence: 99%

“…2016 ). Parietal regions, including the posterior cingulate, precuneus, and angular gyrus, have also been implicated in time orientation and memory for time ( Inhoff and Ranganath 2017 ; Skye et al. 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Neural unscrambling of temporal information during a nonlinear narrative

2023

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Although we must experience our lives chronologically, storytellers often manipulate the order in which they relay events. How the brain processes temporal information while encoding a nonlinear narrative remains unclear. Here, we use functional magnetic resonance imaging during movie watching to investigate which brain regions are sensitive to information about time in a narrative and test whether the representation of temporal context across a narrative is more influenced by the order in which events are presented or their underlying chronological sequence. Results indicate that medial parietal regions are sensitive to cued jumps through time over and above other changes in context (i.e., location). Moreover, when processing non-chronological narrative information, the precuneus and posterior cingulate engage in on-the-fly temporal unscrambling to represent information chronologically. Specifically, days that are closer together in chronological time are represented more similarly regardless of when they are presented in the movie, and this representation is consistent across participants. Additional analyses reveal a strong spatial signature associated with higher magnitude jumps through time. These findings are consistent with prior theorizing on medial parietal regions as central to maintaining and updating narrative situation models, and suggest the priority of chronological information when encoding narrative events.

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Section: Resultssupporting

confidence: 92%

Section: Discussionmentioning

confidence: 95%

“…2022 ). Using lesion-symptom mapping, Skye et al. (2022) pinpointed the precuneus as well as parahippocampal cortex (PHC) as crucially involved in time orientation.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neural unscrambling of temporal information during a nonlinear narrative

2023

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“…For instance, DMN activation has been shown to increase as subjects time progressively longer intervals (Morillon, Kell, and Giraud 2009), and periodic motion expectation also engages the DMN ( (Carvalho et al 2016)). More recently, multivariate lesion-symptom mapping has linked impairments in time awareness (i.e., the awareness of time passing) to disruption in DMN nodes (Skye et al 2022). These findings suggest that the DMN and Timing Network are linked and informative to one another in the support of awareness and understanding of our sense of time.…”

Section: Discussionmentioning

confidence: 95%

Neuroimaging Signatures of Metacognitive Improvement in Sensorimotor Timing

Bader

Wiener

2023

Preprint

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Error monitoring is an essential human ability underlying learning and metacognition. In the time domain, humans possess a remarkable ability to learn and adapt to temporal intervals, yet the neural mechanisms underlying this are not well understood. Recently, we demonstrated that humans exhibit improvements in sensorimotor time estimates when given the chance to incorporate feedback from a previous trial (Bader & Wiener, 2021), suggesting that humans are metacognitively aware of their own timing errors. To test the neural basis of this metacognitive ability, human participants of both sexes underwent fMRI while they performed a visual temporal reproduction task with randomized suprasecond intervals (1-6s). Crucially, each trial was repeated following feedback, allowing a "re-do" to learn from the successes or errors in the initial trial. Behaviorally, we replicated our previous finding that subjects improve their performance on re-do trials despite the feedback being temporally uninformative (i.e. early or late). For neuroimaging, we observed a dissociation between estimating and reproducing time intervals, with the former more likely to engage regions associated with the default mode network (DMN), including the superior frontal gyri, precuneus, and posterior cingulate, whereas the latter activated regions associated traditionally with the "Timing Network" (TN), including the supplementary motor area (SMA), precentral gyrus, and right supramarginal gyrus. Notably, greater DMN involvement was observed in Re-do trials. Further, the extent of the DMN was greater on re-do trials, whereas for the TN it was more constrained. Finally, Task-based connectivity between these networks demonstrated higher inter-network correlation on initial trials, but primarily when estimating trials, whereas on re-do trials communication was higher during reproduction. Overall, these results suggest the DMN and TN work in concert to mediate subjective awareness of one's sense of time for the purpose of improving timing performance.

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Mixed selectivity coding of content-temporal detail by dorsomedial posterior parietal neurons

Wang

Zhou

Zeng

et al. 2022

Preprint

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The dorsomedial posterior parietal cortex is part of a higher-cognition network implicated in elaborate processes underpinning memory formation, recollection, episodes reconstruction, and temporal processing. Neural coding for complex episodic processing is however largely undocumented. Here we revealed a set of neural codes of 'neuroethogram' in the primate parietal cortex. Analyzing neural responses in macaque dmPPC to naturalistic videos, we discovered several groups of neurons that are sensitive to categories of ethogram-items and to low-level sensory features. The amount of information coded within these multiplex representations in turn increases our trained classifier decodability for different video-types. We further discovered that the processing of category and feature information by these neurons is sustained by accumulation of temporal information over a long timescale, corroborating its role at the apex of the cortical hierarchy of temporal receptive windows. Taken altogether, these neural findings explain how dorsomedial PPC weaves fabrics of ongoing experiences together in real-time and realize a multiplex representation of an organism's past. The high dimensionality of neural representations should motivate us to shift the focus of attention from pure selectivity neurons to mixed selectivity neurons, especially in increasingly complex naturalistic task designs.

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Lesion Localization of Time Disorientation in Patients With Focal Brain Damage

Cited by 5 publications

References 49 publications

Neural unscrambling of temporal information during a nonlinear narrative

Neural unscrambling of temporal information during a nonlinear narrative

Neuroimaging Signatures of Metacognitive Improvement in Sensorimotor Timing

Mixed selectivity coding of content-temporal detail by dorsomedial posterior parietal neurons

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