Les séquelles vélopharyngées dans les fentes labioalvéolopalatovélaires. Analyse, bilan et prise en charge orthophonique

Gaillot, A.; Mondié, J.-M.; Buffard, F.; Barthélémy, Isabelle; Sannajust, Jean-Philippe

doi:10.1016/j.stomax.2007.06.007

Cited by 5 publications

(1 citation statement)

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“…Approximately 75% of all complete cleft lip and palate (CLP) patients are AC patients who require alveolar bone grafting (ABG) (Bangun et al, 2023;Destrez et al, 2023). AC, which is situated in the region bounded by the lateral incisors and canines, causes pathologic phonation, orofacial fistulas, fluid reflux, overcrowding, maxillary anterior-posterior and transverse defects, absence of bony support for maxillary anterior teeth, and disruption of the continuity of the maxillary arch (Gaillot et al, 2007;Guo et al, 2011;Tamasas and Cox, 2017;Ahmed et al, 2020;Buile et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Characterization and functional prediction of the dental plaque microbiome in patients with alveolar clefts

Zhang,

Zhi,

Shi

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionAlveolar cleft (AC) is a common congenital defect in people with cleft lip and palate (CLP). Alveolar bone grafting (ABG) is typically performed during adolescence, resulting in the fissure remaining in the mouth for a longer length of time. Patients with AC have a greater rate of oral diseases such as dental caries than the normal population, and the precise characteristics of the bacterial alterations caused by AC are unknown.MethodsWe recruited a total of 87 subjects and collected dental plaque samples from AC adolescents (AAP), post-operative ABG adolescents (PAP), healthy control adolescents (CAP), AC young adults (AYP), post-operative ABG young adults (PYP), and healthy control young adults (CYP). The sequencing of 16S rRNA genes was performed.ResultsThe microbial composition of plaque from alveolar cleft patients differed significantly from age-matched healthy controls. Linear discriminant analysis effect size (LEfSe) analysis revealed that AAP was enriched for Neisseria, Haemophilus, Fusobacterium, Rhodococcus, Aggregatibacter, Gemella, and Porphyromonas, whereas AYP was enriched for Capnocytophaga, Rhodococcus, and Actinomyces-f0332. There were phenotypic differences in facultatively anaerobic, Gram-negative, Gram-positive, and oxidative stress tolerance between the AYP group with longer alveolar cleft and the healthy control group according to Bugbase phenotypic predictions. Alveolar bone grafting did not alter the functional phenotype of alveolar cleft patients but reduced the number of differential genera between alveolar cleft patients and healthy controls at both ages.ConclusionsOur study systematically characterized the supragingival plaque microbiota of alveolar cleft patients, post-alveolar bone grafting patients, and matched healthy controls in two ages to gain a better understanding of plaque ecology and microbiology associated with alveolar clefts.

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