Les plantes immunostimulantes adjuvantes de la th�rapeutique antitumorale*

Goetz, P.

doi:10.1007/s10298-004-0051-0

Cited by 4 publications

(2 citation statements)

References 13 publications

(13 reference statements)

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“…Although our results suggest a significant decrease in the MCHC variable, the absence of a significant change in the total number of red blood cells suggests that CEE-based treatment induced the differentiation of hematopoietic cells by stimulating the differentiation of lymphocyte subpopulations, without increasing the rate of cell divisions. According to previous reports, immunostimulating plants generally induce B lymphocyte maturation and blood cell proliferation [38] [39]. In addition, the significant increase in CVD tends to reinforce this observation.…”

Section: Discussionmentioning

confidence: 63%

Acute and Sub-chronic Toxicity Evaluation of the Ethanolic Extract of Coula edulis B., (Olacaceae) Stem Bark

Beyegue,

Youovop,

Takuissu

et al. 2023

AJRIMPS

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Aims: Coula edulis Baill., (Olacaceae) is a non-lignified forest product not well known and widely used in sub-Saharan Africa as a phytomedicine or food additive. However, the toxicity of this plant remains unknown. This study aimed to assess the safety of the ethanolic extract of C. edulis stem bark (CEE). Study Design: Pharmacological study. Place and Duration of Study: Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1 (Cameroon), between June 2018 and July 2022. Methodology: Studies on the assessment of acute and subchronic toxicity were carried out by guidelines 423 of the Organization for Economic Co-operation and Development (OECD). Subacute toxicity of the sample was assessed over 28 days using repeated doses by OECD Guideline 407. Results: No cases of death and clinical signs of toxicity were observed in the treated rats, suggesting that the LD50 of C. edulis ethanolic extract is greater than 2000 mg/kg bw. Regarding the subacute toxicity study, the administration of CEE also did not result in any changes in the course of body weight. Only a significant decrease in the relative weight of the ovaries in females at the highest dose of 600 mg/kg was observed. In males and females, CEE did not affect lipid profile markers or transaminase levels (AST, ALT). In addition, a small but non-significant (p> 0.05) increase in creatinine was observed without kidney dysfunction. In males, CEE induced an increase in mean corpuscular volume number at 600 mg/kg, while at the same time, mean corpuscular hemoglobin concentration decreased at the 300 mg/kg dose. In females, a significant increase in the number of monocytes, red blood cells, and hemoglobin level were observed. No difference in the levels of urea, glucose, and lipid markers was observed nor histological changes in the organs studied. Conclusion: As would be expected, exposure to CEE did not cause significant toxic effects in treated rats. Therefore, this plant extract can be safely recommended for therapeutic use.

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Section: Discussionmentioning

confidence: 63%

Acute and Sub-chronic Toxicity Evaluation of the Ethanolic Extract of Coula edulis B., (Olacaceae) Stem Bark

Beyegue,

Youovop,

Takuissu

et al. 2023

AJRIMPS

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“…Elle peut aussi permettre aux personnes souffrant de cancer de mieux supporter la chimiothérapie. On connaît par exemple les effets protecteurs d'Echinacea : augmentation de l'immunité et de la résistance chez les patients soumis à la chimiothérapie ou à des irradiations du sein [15]. Les poly saccharides actuellement pourraient être un potentiel impor tant pour leur utilisation en milieu médical.…”

Section: Resultsunclassified

La thérapie par les plantes en Afrique: activités immunostimulantes des polysaccharides de la paroi végétale

2010

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Dans cette revue, nous mettons en avant le potentiel thérapeutique des polysaccharides isolés à partir des parois végé tales des plantes médicinales africaines. In vivo, la paroi végétale joue un rôle important dans le contrôle de la physiologie de la plante (croissance cellulaire, mécanismes de défense de la plante, morphologie de la plante). Principalement composée de polysac charides comme la cellulose, les hémicelluloses ou de pectines, la relation entre la structure chimique de ces polysaccharides et leurs fonctions biologiques a fait l'objet de très nombreuses études. Des extraits de ces parois, principalement polysaccharidi ques, isolés à partir de plantes sont également couramment utili sés comme « remède traditionnel » en Afrique. Dans cette revue, nous présentons quelques plantes médicinales africaines pour lesquelles la structure chimique de certains extraits polysaccha ridiques, présentant souvent une activité immunomodulatoire, a été déterminée. Ce type d'étude et d'approche, encore margi nale, gagnerait à être généralisé aux autres plantes médicinales africaines jusqu'alors peu étudiées. Cette propriété immunomo dulatoire de certains extraits polysaccharidiques pourrait consti tuer un complément thérapeutique de choix chez des patients immunodéprimés ou immunodéficients.Abstract: This review article aims to draw attention to thera peutic potential of plant cell wall polysaccharides isolated from African medicinal plants. Plant cell wall, or plant cell extracel lular compartment, consists on various polysaccharides having different chemical structures. Among these polysaccharides, cellulose, hemicelluloses and pectin polysaccharides are the predominant ones, and play an important role in controlling several biological processes like cell growth and morpho genesis, or defense mechanisms. The structurefunction rela tionship of plant cell wall polysaccharides have been extensively studied, regarding their in vivo biological functions. Here, we have partially described the chemical structure of several biologically active hemicelluloses or pectin polysaccharides extracts, isolated from different African medicinal plants. It appears that these polysaccharides taken individually are able to modulate the activity of the mammal immune system in different manner, providing an interesting complementary therapy to immune deficient patients for instance. Further investigations on cell wall polysaccharide structurebiological activity relationship of the numerous unexplored medicinal plants are therefore strongly suggested.

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Activités antioxydante, apoptotique et antiproliférative de Tetraena gaetula (Emb. & Maire) Beier & Thulin et de Berberis hispanica Boiss. & Reut. originaires du Maroc

Youbi

Bousta

Jamoussi³

et al. 2012

Phytothérapie

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Les plantes immunostimulantes adjuvantes de la th�rapeutique antitumorale*

Cited by 4 publications

References 13 publications

Acute and Sub-chronic Toxicity Evaluation of the Ethanolic Extract of Coula edulis B., (Olacaceae) Stem Bark

Acute and Sub-chronic Toxicity Evaluation of the Ethanolic Extract of Coula edulis B., (Olacaceae) Stem Bark

La thérapie par les plantes en Afrique: activités immunostimulantes des polysaccharides de la paroi végétale

Activités antioxydante, apoptotique et antiproliférative de Tetraena gaetula (Emb. & Maire) Beier & Thulin et de Berberis hispanica Boiss. & Reut. originaires du Maroc

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