Leptospirosis and the antiphospholipid syndrome

Tattevin, Pierre; Dupeux, S.; Hoff, J.érome

doi:10.1016/s0002-9343(02)01365-7

Cited by 10 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some clinical leptospirosis manifestations are related to immunological responses such as in uveitis, arthritis and aseptic meningitis [28][29][30][31]. Four previous studies have demonstrated the presence of anticardiolipin antibodies in leptospirosis patients, and one series of cases found a correlation between the presence of these antibodies in the sera and severe complications from leptospirosis [32][33][34][35]. Finally, Abdulkader et al [36] demonstrated that anti-Leptospira antibody levels are likely to be positively correlated with pulmonary haemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface

Croda

Neto

Brasil

et al. 2010

Clinical Microbiology and Infection

View full text Add to dashboard Cite

Leptospirosis is a zoonotic infection associated with severe diseases such as leptospirosis pulmonary haemorrhage syndrome (LPHS). The cause of pulmonary haemorrhage is unclear. Understanding which mechanisms and processes are involved in LPHS will be important in treatment regimens under development for this life-threatening syndrome. In the present study, we evaluated 30 lung specimens from LPHS patients and seven controls using histology and immunohistochemistry (detection of IgM, IgG, IgA and C3) in order to describe the pathological features associated with this syndrome. Immunoglobulin deposits were detected on the alveolar surface in 18/30 LPHS patients. Three staining patterns were observed for the immunoglobulins and C3 in the lung tissues of LPHS patients: AS, delicate linear staining adjacent to the alveolar surface, which was indicative of a membrane covering the luminal surface of type I and II pneumocyte cells; S, heterogeneous staining which was sporadically distributed along the alveolar septum; and IA, weak, focal intra-alveolar granular staining. Human LPHS is associated with individual and unique histological patterns that differ from those of other causes of pulmonary haemorrhage. In the present study, it was found that the linear deposition of immunoglobulins (IgA, IgG and IgM) and complement on the alveolar surface may play a role in the pathogenesis of pulmonary haemorrhage in human leptospirosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface

Croda

Neto

Brasil

et al. 2010

Clinical Microbiology and Infection

View full text Add to dashboard Cite

show abstract

“…6 Antibodies generated in response to leptospiral infection may cross-react with host antigens, and may be responsible for antiphospholipid syndrome, reactive arthritis, uveitis, and carpal tunnel syndrome. 2,18,19 Antiganglioside antibodies were detected in a 69-year-old white man with neurological complications of leptospirosis presenting with meningomyeloencephalopolyneuritis and nephrotic syndrome. 20 Treatment of severe leptospirosis patients is supportive management and use of appropriate antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Leptospirosis with transient paraparesis and thrombocytopenia: A case report

Wang

Huang

et al. 2012

Journal of Microbiology, Immunology and Infection

View full text Add to dashboard Cite

Leptospirosis is the most widespread zoonosis in the world. We present an unusual case of leptospirosis in a 44-year-old man with severe thrombocytopenia and transient paraparesis. The diagnosis of leptospirosis was confirmed by blood nested polymerase chain reaction, seroconversion of Leptospira IgM and the microscopic agglutination test. Nerve conduction studies were suggestive of early polyneuropathy involving the right peroneal nerve and bilateral sural nerves. Peripheral nerve palsy is a potential clinical feature of leptospirosis.

show abstract

Overlapping clinical features of lupus and leptospirosis

Barnabe

Fahlman

2008

Clin Rheumatol

View full text Add to dashboard Cite

Systemic manifestations of infectious disease may be confused with systemic lupus erythematosus (SLE), leading to potential patient morbidity and mortality. We report the case of a patient with severe renal failure and liver involvement who was initially diagnosed and treated for leptospirosis infection. It was later determined that his organ involvement was related to active SLE. We review the clinical and laboratory features common to both SLE and leptospirosis infection to highlight not only the importance of maintaining a high index of suspicion for infectious organisms in a patient with a suspect travel history but also the recognition of atypical features of a systemic autoimmune disease.

show abstract

Leptospirosis and the antiphospholipid syndrome

Cited by 10 publications

References 4 publications

Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface

Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface

Leptospirosis with transient paraparesis and thrombocytopenia: A case report

Overlapping clinical features of lupus and leptospirosis

Contact Info

Product

Resources

About