Leptomeningeal Carcinomatosis: Easy to Miss

Sekhar, Alakendu; Corbo, B; Das, Kumar; Biswas, Shubhabrata

doi:10.4997/jrcpe.2017.409

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…The 11 articles were evaluated for eligibility. Information about the demographic details and diagnostic modalities are included in Table 1 [3][4][5][6][7][8]. All patients below the age of 65 at the time of LC diagnosis were excluded from the literature review.…”

Section: Resultsmentioning

confidence: 99%

Breast to Brain: A Case Report and Literature Review of Leptomeningeal Carcinomatosis

Ghantarchyan

Win²,

Nagori

et al. 2023

J Med Cases

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Breast cancer is widely known as the most common cancer in women in the United States. If left untreated, it can have detrimental effects. If the breast cancer is aggressive in nature, it can metastasize to the lymph nodes, bones, liver, lungs, and brain. A rare location of metastasis is the leptomeninges, specifically the pia and arachnoid matter. This term is coined as leptomeningeal carcinomatosis. Its diagnosis can be challenging to make as patients can present with non-specific symptoms. We present the case of an elderly female with a prior history of breast cancer that was treated with 12 cycles of chemotherapy with paclitaxel, radiation to her left axilla, and daily anastrozole for 3 years who came into the emergency department for worsening confusion, urinary incontinence, and difficulty ambulating. Cerebral spinal fluid obtained from a lumbar puncture supported a diagnosis of leptomeningeal carcinomatosis.

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Section: Resultsmentioning

confidence: 99%

Breast to Brain: A Case Report and Literature Review of Leptomeningeal Carcinomatosis

Ghantarchyan

Win²,

Nagori

et al. 2023

J Med Cases

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“…It is crucial to image the entire spine from sacrum to foramen magnum in all patients with suspected malignant cord compression [16]. Contrast-enhanced computed tomography is less sensitive and may miss the diagnosis of leptomeningeal metastases in a third of cases [17].…”

Section: Discussionmentioning

confidence: 99%

Dural and Leptomeningeal Spine Metastases of Breast Cancer

Matos

Cerqueira

2019

Case Reports in Radiology

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We present a case of a 57-year-old female diagnosed with invasive ductal breast cancer, which was treated and in remission for 12 years. In 2018 she presented a progressive dorsal back pain, which prevented her from performing basic tasks. An MR study was performed and revealed the presence of an extramedullary metastatic sleeve located in the thoracic intradural space. Concomitant multiple small nodular foci were adhering diffusely to the spinal cord, compatible with leptomeningeal metastatic disease. The occurrence of both forms of spread in the spine is uncommon, and its distinction on imaging is of particular importance taking into account the differences in treatment approach and prognosis.

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“…5 The most important diagnostic measures are clinical evaluation, magnetic resonance imaging (MRI), and analysis of the cerebrospinal fluid (CSF), as it is extremely important to perform a full neurological examination to correctly identify the pathology. 6,7 Disease progression can be well demonstrated through MRI, which is considered useful for the diagnosis of this disease. 8 Additionally, leptomeningeal carcinomatosis is being increasingly diagnosed in patients with cancer due to improved detection through the routine use of MRI.…”

Section: Introductionmentioning

confidence: 99%

Literature Review: Role of Neurosurgery in Leptomeningeal Carcinomatosis

Ogasawara,

Batista,

dos Santos

et al. 2023

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

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Introduction Leptomeningeal carcinomatosis results from metastatic neoplastic cells that reach the leptomeninges through the cerebrospinal fluid. The presentation of the disease is variable, making prognosis challenging. However, the presence of intracranial hypertension is common, which has prompted new treatments to mitigate this effect. Objective To report the role of neurosurgery in the treatment of leptomeningeal carcinomatosis, as well as its advances. Methodology Literature review with a search of the PubMed database, between 2011 and 2021, using the following descriptors: Neurosurgery, Leptomeningeal Carcinomatosis, Cerebrospinal and Treatment. A total of 42 articles were found, 16 of which were selected. Results The shunt insertion considerably improved the effects of cranial hypertension, increasing the average survival time of patients by 3.5 months after surgery. The Ommaya reservoir is also a viable option due to its convenience and safety. The V-Port, on the other hand, has overcome the challenges of conventional devices, with shorter operating times (42 minutes), smaller skin incisions, and no reports of postoperative infection. Conclusion Devices for the treatment of leptomeningeal carcinomatosis have been steadily improving, simplifying surgical procedures and benefiting patients.

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Leptomeningeal Carcinomatosis: Easy to Miss

Cited by 7 publications

References 3 publications

Breast to Brain: A Case Report and Literature Review of Leptomeningeal Carcinomatosis

Breast to Brain: A Case Report and Literature Review of Leptomeningeal Carcinomatosis

Dural and Leptomeningeal Spine Metastases of Breast Cancer

Literature Review: Role of Neurosurgery in Leptomeningeal Carcinomatosis

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