Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients

Yanagawa, Takiko; Taniguchi, Ataru; Fukushima, Mitsuo; Nakai, Yoshikatsu; Nagasaka, Shoichiro; Ohgushi, Minako; Matsumoto, Kazunari; Kuroe, Akira; Ohya, Masaki; Seino, Yutaka

doi:10.1016/j.diabres.2006.04.019

Cited by 22 publications

(14 citation statements)

References 34 publications

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“…As previously reported in a Finnish population [17] as well as Japanese type 2 diabetic patients [13] and healthy individuals [29], an association between leptin and CRP was observed in the Taiwanese cohort analyzed in the present study. The mechanisms linking leptin with CRP are not well known.…”

Section: Discussionsupporting

confidence: 87%

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The association of leptin and C-reactive protein with the cardiovascular risk factors and metabolic syndrome score in Taiwanese adults

Chiu

Chuang

et al. 2012

Cardiovasc Diabetol

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BackgroundSerum C-reactive protein (CRP) and leptin levels have been independently associated with the cardiovascular risk factors. The aim of the present study was to determine if their serum levels were associated with cardiovascular risk factors or metabolic syndrome as well as their correlation in the Taiwanese population.MethodsThis retrospective study included 999 subjects (> 18 y), who underwent a physical examination in Chang-Gung Memorial Hospital-Linkou and Chiayi in Taiwan. The associations between CRP and/or leptin levels and cardiovascular risk factors and metabolic syndrome were determined using independent two sample t-tests to detect gender differences and chi-square tests to evaluate differences in frequencies. To compare the means of the variables measured among the four groups (high and low leptin and high and low CRP), analysis of variance (ANOVA) was used.ResultsBoth CRP and leptin levels were independently associated with several cardiovascular risk factors, including diabetes, hypercholesterolemia and metabolic syndrome in both men and women (P < 0.05). In addition, a positive correlation between leptin and CRP levels was observed in both genders. Both high-CRP and high-leptin were associated with high blood glucose, waist circumference and serum triglyceride. Whereas increased metabolic syndrome incidence was observed in males with elevated leptin regardless of CRP levels, females with elevated CRP or leptin had increased incidence of metabolic syndrome.ConclusionBoth leptin and CRP levels were associated with cardiovascular risk factors as well as metabolic syndrome score in both men and women although gender-specific differences were observed. Thus, CRP and leptin may represent useful biomarkers for predicting the onset of cardiovascular disease or metabolic syndrome in Taiwanese adults.Trial registrationIRB/CGMH 100-3514B

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Section: Discussionsupporting

confidence: 87%

“…In men [11] and patients with type 2 diabetes [12], leptin levels were associated with cardiovascular disease. This association may be through inflammatory mechanisms since leptin and CRP levels have been correlated in a variety of patient populations [13-17]. …”

Section: Introductionmentioning

confidence: 99%

The association of leptin and C-reactive protein with the cardiovascular risk factors and metabolic syndrome score in Taiwanese adults

Chiu

Chuang

et al. 2012

Cardiovasc Diabetol

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“…However, because we did not J Clin Endocrinol Metab, November 2011, 96(11):3448 -3456 measure the small dense LDL, remnant particles, or fasting insulin levels to determine the degree of insulin resistance, we cannot address their role among our study subjects. It was reported in Japanese subjects with type 2 diabetes that the serum triglyceride level is associated with insulin resistance, the visceral fat area (24) and C-reactive protein (25). A prospective study showed that the triglyceride value was a strong predictor of recurrent coronary events in patients with relatively low LDL cholesterol (26).…”

Section: Discussionmentioning

confidence: 98%

Serum Level of Triglycerides Is a Potent Risk Factor Comparable to LDL Cholesterol for Coronary Heart Disease in Japanese Patients with Type 2 Diabetes: Subanalysis of the Japan Diabetes Complications Study (JDCS)

Sone

Tanaka

et al. 2011

The Journal of Clinical Endocrinology & Metabolism

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145

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“…Leptin was shown to promote the development of atherosclerosis by inducing oxidative stress in endothelial cells, increasing platelet aggregation, and hypertrophy and proliferation of vascular smooth muscle cells (4). Additionally, it was shown that a high leptin level predicts subsequent development of T2DM (6). Resistin belongs to a family of cystein-rich secretory proteins called resistin-like molecules or FIZZ (found in inflammatory zones) proteins.…”

Section: Introductionmentioning

confidence: 99%

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Uslu

Kebapçı

Kara

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. The aim of this study was to explore the relationship between serum profiles of adiponectin, leptin, resistin and visfatin and traditional and non-traditional cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). A total of 85 patients with T2DM and 30 non-diabetic controls were enrolled in the study. Levels of adipocytokines (adiponectin, leptin, resistin and visfatin), lipids (total cholesterol, triglycerides), lipoproteins [HDL-cholesterol, LDL-cholesterol, lipoprotein (a)], apolipoproteins (Apo-A1 and Apo-B), non-traditional cardiovascular risk markers [asymmetric dimethylarginine (ADMA), homocysteine] and the inflammatory marker hs-CRP were measured, and anthropometric variables were determined. Serum adiponectin levels were decreased and leptin, resistin and visfatin levels were increased in T2DM patients compared to controls. They were associated with obesity (BMI), insulin resistance (HOMA-IR) and various markers of glucose/lipid profile, inflammation and endothelial dysfunction markers. These results suggest that decreased serum adiponectin and increased leptin, resistin and visfatin levels in T2DM may be novel biochemical risk factors for cardiovascular complications.

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Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients

Cited by 22 publications

References 34 publications

The association of leptin and C-reactive protein with the cardiovascular risk factors and metabolic syndrome score in Taiwanese adults

The association of leptin and C-reactive protein with the cardiovascular risk factors and metabolic syndrome score in Taiwanese adults

Serum Level of Triglycerides Is a Potent Risk Factor Comparable to LDL Cholesterol for Coronary Heart Disease in Japanese Patients with Type 2 Diabetes: Subanalysis of the Japan Diabetes Complications Study (JDCS)

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

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