Leptin serum levels in rheumatoid arthritis patients: relation to disease duration and activity

Targońska-Stępniak, Bożena; Majdan, Maria; Dryglewska, Magdalena

doi:10.1007/s00296-007-0480-9

Cited by 76 publications

(55 citation statements)

References 26 publications

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“…There was also a tendency of correlation between leptin level and cystatin C concentration (novel renal function parameter). The results suggested, that leptin levels were increased in pts with higher disease activity and the risk of progressive joint destruction [12]. 9 In the present study we confirmed the observation of proinflammatory leptin function in the course of RA.…”

Section: Discussionsupporting

confidence: 89%

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Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

2009

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International audienceAdipose tissue is regarded as an active metabolic and endocrine organ producing adipokines. The purpose of the study was to evaluate adiponectin and leptin concentrations in rheumatoid arthritis (RA) patients (pts) in relation to disease duration and activity. The study group consisted of 80 RA pts. Serum adiponectin and leptin concentrations remained within normal ranges. Adiponectin concentration correlated positively both with the age and disease duration. Both adipokines levels correlated negatively with glomerular filtration rate. There were significant positive correlations between adipokines' concentrations and lipid profile components (between adiponectin and HDL-cholesterol, leptin and total cholesterol and LDL-cholesterol). In pts with long-standing RA, there was a negative correlation between adiponectin and numbers of tender, swollen joints and a positive relationship between leptin level and DAS28. The results confirm adipokines' involvement in the process of inflammation and atherosclerosis: protective and antiinflammatory adiponectin effect and proatherogenic and proinflammatory leptin function

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Section: Discussionsupporting

confidence: 89%

“…Leptin concentrations were found to be similar [12,13,14,15,16], lower [17], or higher [18,19] in comparison with healthy controls or with pts with osteoarthritis (OA) [20]. Plasma levels of adiponectin, leptin and visfatin were found to be increased in RA pts [21] or did not differ significantly in RA pts and in healthy controls [22].…”

Section: Introductionmentioning

confidence: 99%

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

2009

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“…In one study, 75 serum leptin concentrations were higher in patients with erosive RA. Another study has shown that concentrations of leptin in synovial fluid were lower than those found in the plasma of patients with nonerosive RA, but not in those with erosive disease.…”

Section: Leptin and Autoimmunity M Vadacca Et Al 207mentioning

confidence: 91%

Leptin in immuno-rheumatological diseases

et al. 2011

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Leptin is one of the most important hormones secreted by adipocytes, with a variety of physiological roles related to the control of metabolism and energy homeostasis. Since its discovery in 1994, leptin has attracted increasing interest in the scientific community for its pleiotropic actions. One of these functions is the relationship between nutritional status and immune competence. It structurally resembles proinflammatory cytokines, such as IL-6 and IL-12. The cytokine-like structural characteristic of leptin is implicative of its function in regulating immune responses. The role of leptin in regulating immune responses has been assessed in vitro as well as in clinical studies. It has been shown that disease conditions of reduced leptin production are associated with increased infection susceptibility. Conversely, immune-mediated disorders, such as autoimmune diseases, are associated with the increased secretion of leptin and the production of proinflammatory pathogenic cytokines. In this paper, we review the most recent advances of the role of leptin in immune-rheumatological diseases, and we discuss whether strategies aimed at modifying leptin levels could represent innovative and therapeutic tools for autoimmune disorders. Keywords: adipokines; autoimmune diseases; leptin; rheumatic diseases INTRODUCTIONThe existence of a factor secreted by white adipose tissue (WAT), which acts to control feeding, weight and WAT mass, was first proposed by Kennedy 1 and is supported by monogenic mutations resulting in obesity. [2][3][4] WAT is composed of adipocytes filled mainly with triacylglycerol and embedded in loose connective tissue containing adipocyte precursors, fibroblasts, immune and other cells. Obesity, the condition that originally motivated the research on WAT, is characterized by low-grade systemic inflammation. It is thought that excess WAT can contribute to the maintenance of obesity through inflammation-inducing lipotoxicity by secreting factors that stimulate the synthesis of inflammatory agents in other organs and by secreting inflammatory agents itself. 5 The current view of WAT states that it is an active contributor to body homeostasis by sending out and responding to signals that modulate appetite, energy expenditure, insulin sensitivity, the endocrine and reproductive systems, bone metabolism, inflammation and immunity. 6 Several findings have converged to indicate that adipocytes share certain properties with immune cells, such as complement activation 7 and proinflammatory cytokine production. 8 Fat cell precursors also share features with macrophages. Numerous genes that code for transcription factors, cytokines, inflammatory signaling molecules, and fatty acid transporters are essential for adipocyte biology and are also expressed and functional in macrophages. 9 Adipose tissue secrets a variety of factors: the term 'adipokine' is generally given to any protein that can be synthesized and secreted by adipocytes. Among these factors, only leptin and adiponectin (and possibly resistin, adipsi...

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“…Recent work has shown that serum leptin levels can correlate with the level of inflammation. The concentration of leptin is elevated during active disease in rheumatoid arthritis patients, and it decreases when the disease is controlled [94][95].…”

Section: Leptin and Inflammationmentioning

confidence: 99%

Leptin and Inflammation

Iikuni¹,

Lam²,

Lu³

et al. 2008

CIR

303

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The past few years of research on leptin have provided important information on the link between metabolism and immune homeostasis. Adipocytes influence not only the endocrine system but also the immune response through several cytokine-like mediators known as adipokines, which include leptin. It is widely accepted that leptin can directly link nutritional status and pro-inflammatory T helper 1 immune responses, and that a decrease of leptin plasma concentration during food deprivation can lead to an impaired immune function. Additionally, several studies have implicated leptin in the pathogenesis of chronic inflammation, and the elevated circulating leptin levels in obesity appear to contribute to the low-grade inflammatory background which makes obese individuals more susceptible to increased risk of developing cardiovascular diseases, type II diabetes, or degenerative disease including autoimmunity and cancer. Conversely, reduced levels of leptin such as those found in malnourished individuals have been linked to increased risk of infection and reduced cell-mediated immune responses. We discuss here the functional influences of leptin in the physiopathology of inflammation, and the effects of leptin in the modulation of such responses.

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Leptin serum levels in rheumatoid arthritis patients: relation to disease duration and activity

Cited by 76 publications

References 26 publications

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

Leptin in immuno-rheumatological diseases

Leptin and Inflammation

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