Leptin resistance is associated with extreme obesity and aggregates in families

Lee, Joseph H.; Reed, Danielle R.; Price, Richard A.

doi:10.1038/sj.ijo.0801736

Cited by 63 publications

(46 citation statements)

References 9 publications

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“…Our study is also in agreement with the study conducted by Concidine et al, [3] who demonstrated higher leptin levels in obese subjects. Our study is also in agreement with study conducted by Lee et al [4] who measured leptin levels in obese and average weight adults. Figure 1 shows Pearson's coefficient correlation between BMI and leptin values in obese subjects.…”

Section: Discussionsupporting

confidence: 83%

Leptin signaling - Leptin resistance in obesity and its correlation with body mass index

Sharma¹,

Sharma²

2018

Natl J Physiol Pharm Pharmacol

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Background: Obesity is a worldwide problem and is a risk factor for multiple health problems. Leptin is an adipokine with a role in energy homeostasis and interruption in its action leads to obesity. Aims and Objectives: The present study is conducted to determine leptin levels in obese and normal weight adults and correlate the leptin levels with body mass index (BMI) among obese. Materials and Methods: The study comprised of 50 healthy obese subjects and 20 normal weight controls in the age group of 30-45 years of either sex. BMI and serum leptin were measured for both subjects and control. Results: The study demonstrates higher leptin levels in obese as compared to normal weight adults (P < 0.0001) and significant positive Pearson correlation coefficient between serum leptin and BMI among obese. Conclusion: Leptin circulates excessively in obese, and measures should be taken to reduce the refractoriness of leptin to regulate the energy homeostasis.

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Section: Discussionsupporting

confidence: 83%

Leptin signaling - Leptin resistance in obesity and its correlation with body mass index

Sharma¹,

Sharma²

2018

Natl J Physiol Pharm Pharmacol

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“…Its release occurs during the peak of the night and the first hours of the morning, and its plasma half-life is of 30 minutes 6 . Leptin concentration is partially related to the size of the mass of the adipose tissue in the body 7,8 . It is known as the "satiety hormone" for having influence on the appetite reduction process 3 .…”

Section: Introductionmentioning

confidence: 99%

Efeitos agudos do treinamento concorrente sobre os níveis séricos de leptina e cortisol em adultos jovens sobrepesados

Cruz

Rosa

Valle

et al. 2012

Rev Bras Med Esporte

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Objective: This study aimed to analyze the immediate effects of concurrent training on leptin and cortisol levels in overweighed young adults. Methods: This study used a quasi-experimental methodology. We included 20 volunteers of both sexes, randomly divided into a training competitor group (TCG n = 10) and a control group (C n = 10). Blood collection was performed in individuals at rest after fasting for 12 hours. The leptin and cortisol levels were analyzed by radioimmunoassay and chemiluminescence immunoassay before and immediately after training. Two-way ANOVA was used for statistical analysis with a significance level of p <0.05. Results: In the analysis of leptin levels, there was significant difference between groups (TCG x C) in the pre intervention (p = 0.02) and post intervention (p = 0.01). In the intra groups, no significant changes were found, and in the analysis of cortisol levels between groups (TGC x C), a significant difference in the pre intervention (p = 0.01) and post intervention (p = 0.01) was observed; however, in the intra groups there were no significant changes. Conclusion: A single concurrent training session is not sufficient to promote acute changes in the leptin and cortisol levels of the volunteer overweighed young adults in this study.

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“…Em humanos, a concentração plasmática de leptina está parcialmente relacionada ao tamanho da massa de tecido adiposo presente no corpo (15,16), pois seus níveis plasmáticos diferem em indivíduos com mesmo índice de massa corporal (17). Além disso, mulheres geralmente apresentam níveis maiores de leptina do que homens (11), e em algumas patologias, como o diabetes mellitus do tipo II, os níveis plasmáticos de leptina apresentam-se elevados.…”

Section: Leptinaunclassified

“…Uma falha na sua produção e/ou na sua ação sobre os receptores hipotalâmicos poderia desequilibrar positivamente o balanço energético, gerando o quadro de obesidade (12). No entanto, estudos realizados em humanos mostram que os níveis plasmáticos de leptina são elevados em obesos quando comparados com seus congêneres magros (16,(33)(34)(35). Crianças pré-púberes e adolescentes obesos também apresentam níveis de leptina mais elevados do que indivíduos magros da mesma faixa etária (36).…”

Section: Mecanismos De Ação Da Leptina Na Ingestão Alimentarunclassified

Leptina, ghrelina e exercício físico

Mota

Zanesco

2007

Arq Bras Endocrinol Metab

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RESUMOA obesidade é atualmente um problema de saúde pública que provoca sérias conseqüências sociais, físicas e psicológicas. A etiologia da obesidade não é de fácil identificação, uma vez que a mesma é caracterizada como doença multifatorial de complexa interação entre fatores comportamentais, culturais, genéticos, fisiológicos e psicológicos. Recentes avanços na área de endocrinologia e metabolismo mostram que, diferentemente do que se acreditava há alguns anos, o adipócito sintetiza e libera diversas substâncias, não sendo apenas uma célula armazenadora de energia. Entre as substâncias liberadas pelo adipócito incluem-se a adiponectina, o fator de necrose tumoral-α, a interleucina-6 e a leptina. Especificamente, a leptina desempenha importante papel no controle da ingestão alimentar e no controle do peso corporal em mamíferos. Além disso, o hormônio ghrelina, recentemente descoberto, também parece influenciar o metabolismo energético e a obesidade. As alterações que o exercício físico provoca na fisiologia endócrino-metabólica podem contribuir sobremaneira para a prática clínica. Assim, essa revisão abordará os conhecimentos mais recentes sobre a leptina, a ghrelina e o papel dos diferentes tipos de exercício físico sobre estes hormônios. Os trabalhos mostram que a relação entre o exercício físico e a concentração plasmática desses peptídeos ainda não está clara. As razões para isso poderiam ser devidas aos diferentes protocolos de treinamento físico empregados nos estudos. Além disso, diferenças genéticas também podem explicar as discrepâncias entre os resultados obtidos em seres humanos, pois a existência de polimorfismo em alguns genes pode acarretar respostas celulares diferentes frente ao exercício físico. Obesity is a major public health problem in the Western world resulting in serious social, physical and psychological damages. The genesis of obesity is complex involving a variety of factors such as genetic, psychological, metabolic and environmental factors. Progress in endocrinology and metabolism show that adipocyte is considered now as an endocrine tissue producing several substance including adiponectin, tumor necrosis factor-α, interleukin-6 and leptin. Specifically, leptin is the main peptide produced by the adipocyte and its serum concentration represents an important peripheral signal in the regulation of food intake and energy expenditure in mammals. In addition to leptin, a new peptide was discovered recently named ghrelin. Ghrelin, a peptide hormone identified in the stomach, is directly involved with the regulation of energy balance and obesity. Physical exercise has been used as a non-pharmacological tool in management of body weight and the effect of physical activity on weight control is an important issue for clinical studies in endocrinology field. Thus, this review will attempt to update the knowledge of leptin and ghrelin on the body weight regulation and the effect of exercise training on these peptide concentrations. It can be concluded that the relationship between physical exer...

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Leptin resistance is associated with extreme obesity and aggregates in families

Cited by 63 publications

References 9 publications

Leptin signaling - Leptin resistance in obesity and its correlation with body mass index

Leptin signaling - Leptin resistance in obesity and its correlation with body mass index

Efeitos agudos do treinamento concorrente sobre os níveis séricos de leptina e cortisol em adultos jovens sobrepesados

Leptina, ghrelina e exercício físico

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