Leptin regulates neuropeptides associated with food intake and GnRH secretion

Guzmán, Adrián; Hernández‐Coronado, Cyndi G.; Rosales‐Torres, Ana María; Hernandez-Medrano, Juan

doi:10.1016/j.ando.2018.07.012

Cited by 35 publications

(28 citation statements)

References 95 publications

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“…In our study, the up-regulated expressions of leptin receptor (LEPR), KISS1 and GNRH1 mRNA may also relate to positive energy balance caused by the abnormal elevation of testosterone disorder in DSD pig [21; 61]. In a positive energy balance, leptin has negative effects on the expression of AgRP and NPY [62], which can repress GnRH secretion in a direct or indirect fashion [57; 63; 64]. Controversially, the expressions of AGRP and NPY also increased in our study.…”

Section: Discussionmentioning

confidence: 92%

Comprehensive transcriptome analysis of hypothalamus reveals genes associated with disorders of sex development in pigs

Tan

Zhou

Zhao

et al. 2021

The Journal of Steroid Biochemistry and Molecular Biology

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BackgroundDisorders of sex development (DSD) is a chronic autoimmune disease characterized by systemic in ammation, pathological osteogenesis, and endocrine abnormality. However, its genetic etiology remains mostly unknown. In addition, little research focuses on the regulation mechanism from the view of transcriptomics in the hypothalamic-pituitary-gonadal axis (HPGA). The hypothalamus is the integrated center of the HPGA mediating neural, hormonal, and environmental stimulus to sex development. MethodsThree XX-DSD (SRY-negative) pig (DSD) and three NF pigs ( ve months old, 40 kg ± 5 kg) were selected by external genitalia observation and sex determining region Y gene (SRY) detection. The hypothalamus were sampled for RNA isolation, and the mRNA, lncRNA and miRNA expression pro les were analyzed by sequencing. ResultsA total of 1,258 lncRNAs, 1,086 mRNAs, and 61 microRNAs were found to differentially express in XX-DSD pigs compared with normal female pigs. Many genes in hormone biosynthesis and secretion pathway are signi cantly up-regulated, and the upregulation of GNRH1, KISS1 and AVP may be the candidate genes leading the abnormal secretion of GnRH. Next, we predicted the lncRNA-miRNA-mRNA co-expression triplets and constructed three competing endogenous RNA (ceRNA) potentially associated with DSD. Functional enrichment suggested TCONS_00340886, TCONS_00000204 and miR-181a were related to GnRH secretion. ConclusionsOur research revealed the rst transcriptomic pro le in the hypothalamus of XX-DSD pigs and provided new insight in coding and non-coding RNAs that may be associated with DSD in pigs.

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Section: Discussionmentioning

confidence: 92%

Comprehensive transcriptome analysis of hypothalamus reveals genes associated with disorders of sex development in pigs

Tan

Zhou

Zhao

et al. 2021

The Journal of Steroid Biochemistry and Molecular Biology

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“…POMC neurons, as a key upstream factor affecting hypothalamic hormone release, were found to be sensitive to metabolic hormones such as leptin (Wilson and Enriori, 2015) and enhance kisspeptin neuron activities in rodents, resulting in increased GnRH secretion (Muroi and Ishii, 2016). Leptin can act in the hypothalamus directly, eliciting the release of GnRH (Guzmán et al, 2019), and promoting the expression of POMC (Perello et al, 2007). Although the stimulatory effects of POMC on kisspeptin have been known for a long time, how this signaling is established remains poorly understood (Saedi et al, 2018).…”

Section: Functional Analysis Of Degs In Pf Vs Mfmentioning

confidence: 99%

“…The expression of PRL was detected not only in the follicular phase but also in the luteal phase, and interestingly, there was a reverse expression pattern of PRL between PF vs. MF and PL vs. ML, suggesting its crucial roles in reproduction. The effects of leptin on GnRH release have been revealed (Guzmán et al, 2019), and the infusion of leptin into the arcuate nucleus in rats could cause PRL release (Watanobe, 2010), which suggested that PRL can be a downstream factor activated by leptin to function in GnRH activities. In addition, the overexpression of growth hormone (GH) could disrupt the state of reproduction, mainly through mediating leptin activities (Chen et al, 2018).…”

Section: Functional Analysis Of Degs In Pl Vs MLmentioning

confidence: 99%

Integrated Hypothalamic Transcriptome Profiling Reveals the Reproductive Roles of mRNAs and miRNAs in Sheep

Zhang

Tang

et al. 2020

Front. Genet.

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Early studies have provided a wealth of information on the functions of microRNAs (miRNAs). However, less is known regarding their functions in the hypothalamus involved in sheep reproduction. To explore the potential roles of hypothalamic messenger RNAs (mRNAs) and miRNAs in sheep without FecB mutation, in total, 172 and 235 differentially expressed genes (DEGs) and 42 and 79 differentially expressed miRNAs (DE miRNAs) were identified in polytocous sheep in the follicular phase versus monotocous sheep in the follicular phase (PF vs. MF) and polytocous sheep in the luteal phase versus monotocous sheep in the luteal phase (PL vs. ML), respectively, using RNA sequencing. We also identified several key mRNAs (e.g., POMC, GNRH1, PRL, GH, TRH, and TTR) and mRNA-miRNAs pairs (e.g., TRH co-regulated by oar-miR-379-5p, oar-miR-30b, oar-miR-152, oar-miR-495-3p, oar-miR-143, oar-miR-106b, oar-miR-218a, oar-miR-148a, and PRL regulated by oar-miR-432) through functional enrichment analysis, and the identified mRNAs and miRNAs may function, conceivably, by influencing gonadotropinreleasing hormone (GnRH) activities and nerve cell survival associated with reproductive hormone release via direct and indirect ways. This study represents an integral analysis between mRNAs and miRNAs in sheep hypothalamus and provides a valuable resource for elucidating sheep prolificacy.

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“…Diabetic female rats exhibited lowered KISS-1 mRNA levels in the hypothalamus [150]. Additionally, leptin elevates kisspeptin gene expression [151] and is able to depolarize kisspeptin neurons [152].…”

Section: Pathophysiological Consequences: Effect Of Obesity-induced Imentioning

confidence: 96%

Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences

Barabás

Szabó-Meleg

Ábrahám

2020

IJMS

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Inflammation has a well-known suppressive effect on fertility. The function of gonadotropin-releasing hormone (GnRH) neurons, the central regulator of fertility is substantially altered during inflammation in females. In our review we discuss the latest results on how the function of GnRH neurons is modified by inflammation in females. We first address the various effects of inflammation on GnRH neurons and their functional consequences. Second, we survey the possible mechanisms underlying the inflammation-induced actions on GnRH neurons. The role of several factors will be discerned in transmitting inflammatory signals to the GnRH neurons: cytokines, kisspeptin, RFamide-related peptides, estradiol and the anti-inflammatory cholinergic pathway. Since aging and obesity are both characterized by reproductive decline our review also focuses on the mechanisms and pathophysiological consequences of the impact of inflammation on GnRH neurons in aging and obesity.

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Leptin regulates neuropeptides associated with food intake and GnRH secretion

Cited by 35 publications

References 95 publications

Comprehensive transcriptome analysis of hypothalamus reveals genes associated with disorders of sex development in pigs

Comprehensive transcriptome analysis of hypothalamus reveals genes associated with disorders of sex development in pigs

Integrated Hypothalamic Transcriptome Profiling Reveals the Reproductive Roles of mRNAs and miRNAs in Sheep

Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences

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