Leptin receptor gene (A/G) polymorphism rs1137101 and renal cell carcinoma

Allah, Azza M Abdu; El-Hefnway, Sally M.; Alhanafy, Alshimaa Mahmoud; Zahran, Ahmed; Kasem, Heba E.

doi:10.1007/s11010-018-3320-1

Cited by 15 publications

(11 citation statements)

References 27 publications

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“…In the current study, we found that the GA and GA+AA genotypes of rs1137101 were associated with decreased breast cancer risk. Some previous case–control studies reported that the A allele of rs1137101 is a protective factor against cancer occurrence ( 26 , 40 , 41 ), which were consistent with our results, but some studies have shown the opposite results ( 42 , 43 ). The inconsistent results may be due to differences in race, genetic background, environment, or lifestyle.…”

Section: Discussionsupporting

confidence: 92%

Single-Nucleotide Polymorphisms in LEP and LEPR Associated With Breast Cancer Risk: Results From a Multicenter Case–Control Study in Chinese Females

et al. 2022

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BackgroundLeptin (LEP) plays a physiological role through its specific receptor (LEPR) and is involved in the occurrence and development of breast cancer. Our current study aimed at determining the influence of single-nucleotide polymorphisms (SNPs) in the genes coding for LEP and LEPR on breast cancer risk.MethodsIn the present study, 963 breast cancer cases and 953 controls were enrolled. Five SNPs of LEP and two of LEPR were chosen to evaluate the correlation of selected SNPs with breast cancer susceptibility among women in northern and eastern China. Analyses were further stratified by body mass index (BMI), waist–hip rate (WHR), estrogen receptor, and progesterone receptor status. The expression patterns of risk variant-associated genes were detected by expression quantitative trait locus (eQTL) analysis with eQTLGen and The Cancer Genome Atlas database.ResultsThere were significant differences between breast cancer cases and control groups in the menopausal status and family history of breast cancer. Two SNPs (rs1137101 and rs4655555) of the LEPR gene decreased overall breast cancer risk, and other five SNPs showed no significant association with breast cancer risk. rs1137101 (GA vs. GG; adjusted OR = 0.719, 95% CI = 0.578–0.894, p = 0.003) and rs4655555 (TT vs. AA; adjusted OR = 0.574, 95% CI = 0.377–0.873, p = 0.009) significantly decreased breast cancer risk after Bonferroni correction for multiple testing. In subgroup analyses, the GA and GA + AA genotypes of LEPR rs1137101 associated with decreased breast cancer risk in the subgroup of BMI ≤ 24 kg/m2 or WHR ≥ 0.85 after Bonferroni correction. Furthermore, we found that the expressions of rs4655555-associated gene LEPR and leptin receptor overlapping transcript (LEPROT) were upregulated in breast cancer tumor tissues compared with adjacent normal tissues, and a higher expression of LEPR in tumor tissues was correlated with poor prognosis of breast cancer patients using The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) data.ConclusionOur study demonstrated that the polymorphisms rs1137101 and rs4655555 located in the LEPR gene decreased breast cancer risk in Chinese females, which might be a research-worthy bio-diagnostic marker and applied for early prediction and risk assessment of breast cancer.

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Section: Discussionsupporting

confidence: 92%

Single-Nucleotide Polymorphisms in LEP and LEPR Associated With Breast Cancer Risk: Results From a Multicenter Case–Control Study in Chinese Females

et al. 2022

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“…Therefore, the involved patients in the early-onset psoriasis group should be approached differently as regards lifestyle recommendations. Further findings in certain populations—that besides obesity, rs1137101 has been linked to type 2 diabetes mellitus [ 46 ], various types of cancer such as endometrial [ 47 ], prostate [ 48 ], colorectal [ 49 ] and renal cell carcinoma [ 50 ] as well as to keloid formation [ 51 ], multiple sclerosis severity score [ 52 ], the outcome of renal transplantation [ 53 ] and to susceptibility to polycystic ovary syndrome [ 54 ]—suggests that sub-stratification and follow up of the involved individuals may also be a promising basis for prevention strategies.…”

Section: Discussionmentioning

confidence: 99%

Leptin Receptor (rs1137101) and Brain-Derived Neurotrophic Factor (rs925946) Gene Variants Are Associated with Obesity in the Early- but Not in the Late-Onset Population of Hungarian Psoriatic Patients

Szentkereszty-Kovács

Fiatal

Janka

et al. 2021

Life

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Background: Psoriatic patients have considerably higher odds of being obese compared with the general population; however, the exact pathophysiological link between psoriasis and obesity needs to be elucidated. Methods: To investigate the association of psoriasis with established obesity-related gene variants, we conducted a population-based case-control study including 3541 subjects (574 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 20 SNPs at ADIPOQ, BDNF, FTO, GNPDA2, LEPR, MC4R, NEGR1, NPY, PPARG, TMEM18, and UCP2 were determined, and differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were implemented. Results: Analysis revealed an association between the G allele of the rs1137101 polymorphism (LEPR gene) and obesity risk (OR: 3.30 (1.45; 7.50), p = 0.004) in the early-onset group of psoriatic patients. Furthermore, the T allele of rs925946 polymorphism (BDNF gene) was also associated with increased risk of obesity in early-onset psoriasis (OR: 2.26 (1.24; 4.14) p = 0.008). Conclusions: Our results suggest that in psoriatic patients, there are prominent differences in the causes of obesity that should be accounted for, including not only environmental factors but also patient characteristics, such as the time of disease onset as well as genetic factors.

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“…Apart from the methylation, the presence of Gln223Arg (A/G) rs1137101 SNP was also found to affect the risk of RCC and patients’ survival [ 206 ]. The GG genotype is associated with more aggressive tumour behaviour and shorter survival compared with GA and AA genotypes.…”

Section: Mechanisms Linking Obesity With Cancersmentioning

confidence: 99%

Renal Cell Cancer and Obesity

Gluba-Brzózka

Rysz

Ławiński

et al. 2022

IJMS

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Cancers are a frequent cause of morbidity and mortality. There are many risk factors for tumours, including advanced age, personal or family history of cancer, some types of viral infections, exposure to radiation and some chemicals, smoking and alcohol consumption, as well as obesity. Increasing evidence suggest the role of obesity in the initiation and progression of various cancers, including renal cell carcinoma. Since tumours require energy for their uncontrollable growth, it appears plausible that their initiation and development is associated with the dysregulation of cells metabolism. Thus, any state characterised by an intake of excessive energy and nutrients may favour the development of various cancers. There are many factors that promote the development of renal cell carcinoma, including hypoxia, inflammation, insulin resistance, excessive adipose tissue and adipokines and others. There are also many obesity-related alterations in genes expression, including DNA methylation, single nucleotide polymorphisms, histone modification and miRNAs that can promote renal carcinogenesis. This review focuses on the impact of obesity on the risk of renal cancers development, their aggressiveness and patients’ survival.

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Leptin receptor gene (A/G) polymorphism rs1137101 and renal cell carcinoma

Cited by 15 publications

References 27 publications

Single-Nucleotide Polymorphisms in LEP and LEPR Associated With Breast Cancer Risk: Results From a Multicenter Case–Control Study in Chinese Females

Single-Nucleotide Polymorphisms in LEP and LEPR Associated With Breast Cancer Risk: Results From a Multicenter Case–Control Study in Chinese Females

Leptin Receptor (rs1137101) and Brain-Derived Neurotrophic Factor (rs925946) Gene Variants Are Associated with Obesity in the Early- but Not in the Late-Onset Population of Hungarian Psoriatic Patients

Renal Cell Cancer and Obesity

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