Leptin, osteocalcin, and bone mineral density in post-hepatitic liver cirrhosis

Ahmed, Hanan; El-Shereef, Hala K.; El-Gendi, Salwa S.; El-Sherif, Wafaa T; Bakheet, Madeeha Younis; Galal, Ghada Moustafa; Abdel-Wahab, Sherif H.; El-Moneum, Omnia Abd

doi:10.1016/j.ajg.2010.07.006

Cited by 3 publications

(6 citation statements)

References 30 publications

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“…Another study by Goubraim et al [36] found a high prevalence of BMD abnormalities in cirrhotic patients (post viral B, C) with total rate of 80.4%, osteoporosis was found in 28.2% of cases and osteopenia in 52.2% of cases. Some Egyptian studies have also found high rates of bone loss in patients with cirrhosis: 87.8% in Salama et al [37] and 86.6% in Ahmed et al [38]. These variable percentages of bone disease in chronic HCV in comparison to this study may be related to age, gender, stage of liver disease as well as nutritional state and most studies which reported high percentage were decompensated cirrhosis.…”

Section: Discussionsupporting

confidence: 39%

Osteoporosis in Chronic Hepatitis C

Abdelkader

Hegazy

Elbadrawy

et al. 2014

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Background and study aim: Hepatitis C virus infection is a multisystemic disease with many extrahepatic manifestations. Affection of bone matrix density is a common complication of chronic hepatitis and cirrhosis. The pathogenesis of osteoporosis in chronic liver disease is still unknown and is expected to be multifactorial. The aim of this work is to assess the frequency of osteoporosis/osteopenia in patients with chronic hepatitis C virus infection with or without cirrhosis. Patients and Methods: This study was carried out on 30 patients with chronic HCV infection without cirrhosis (Group II), 30 patients with chronic HCV infection with compensated cirrhosis (Group III) and 20 age and gender matched healthy controls (Group I). All subjects of the study performed liver function tests, viral markers, liver biopsy, hormonal assay and Bone Mineral density measurement (BMD) by Dual energy Xray absorptiometry (DEXA). Results: In patients with chronic hepatitis C (group II) the frequency of osteopenia was 11 (36.7%), osteoporosis 2 (6.7 %), total patients with low BMD was 13 (43.3%). In cirrhotic patients (group III), the frequency of osteopenia was 13 (43.3%), osteoporosis was 3 (10.0%), and total patients with low BMD was 16(53.3%) vs 1(5.0%) in the control group (group I). there was also no significant difference between patients with low BMD and patients with normal BMD as regards age, gender, common risk factors, liver function tests or hormonal levels. Conclusion: Reduced BMD is common chronic HCV-infected patients with and without cirrhosis. HCV infection is a risk factor of osteoporosis.

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Section: Discussionsupporting

confidence: 39%

Osteoporosis in Chronic Hepatitis C

Abdelkader

Hegazy

Elbadrawy

et al. 2014

Afro-Egyptian Journal of Infectious and Endemic Diseases

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“…Our results were similar to those found in a previous study [ 11 ] who noted low BMD in 80% of a comparable patient's population. Two Egyptian studies recently published have also found high rates of bone loss in patients with cirrhosis: 86.6% in Ahmed et al's study [ 4 ] and 87.8% in Salama et al's series [ 12 ]. These findings allow us to suggest that Moroccan cirrhotic patients have approximately the same osteodensitometric profile to the rest of North-African population.…”

Section: Discussionmentioning

confidence: 97%

“…With progress in the therapy of liver cirrhosis and its complications, there has been an increase in patient survival and, hence, an increased incidence of metabolic bone disorders especially osteoporosis and its fracture risk. The prevalence of these osteometabolic changes in chronic liver disease varies from 13% to over 80%, depending on the population studied and the diagnostic criteria used to define bone disease [ 4 , 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Insulin-like growth factor-I which is produced by the liver and the bone and stimulates osteoblast's proliferation was found decreased in viral cirrhosis related osteoporosis. Ahmed et al [ 4 ] suggested that leptin, a strong inhibitor of bone formation, may play a role in the pathogenesis of osteoporosis in postviral cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

“…The association between metabolic bone abnormalities and chronic liver disease is now well recognized. Often known as hepatic osteodystrophy, these disorders are a common complication of liver cirrhosis with a reported prevalence of 12% to 86% [ 1 – 4 ]. Osteoporosis is the well-known major complication of hepatic osteodystrophy.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Bone Disease in Viral Cirrhosis: A Prospective Study

et al. 2013

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Background/Aim. Metabolic Bone disorders are well-recognized extrahepatic complications of cirrhosis. The aim was to report their prevalence and the associated factors to their development in patients with viral cirrhosis. Patients and Methods. All consecutive patients with viral cirrhosis were prospectively enrolled. Parathyroid hormone, 25-hydroxyvitamin D, liver function, and phosphocalcic tests were measured in all patients. Bone mineral density was measured at the lumbar spine and total hip by dual-energy X-ray absorptiometry. Data were analyzed using SPSS software. Results. Forty-six cirrhotic patients were included with hepatitis C (87%) and hepatitis B (13%). The Child-Pugh score was grade A in 87% of cases and grade B in 13%. Thirty-seven patients had decreased bone mineral density with osteopenia in 24 patients and osteoporosis in 13 patients. Decreased 25-hydroxyvitamin D was found in 95.6% of cases. Bone disorders were significantly more frequent in old patients with low body mass index, long duration of liver disease, and low 25-hydroxyvitamin D level. None of these factors was an independent factor associated with bone disorders. Conclusion. Our study revealed a high prevalence of metabolic bone disorders among viral cirrhotic patients. Consequently, bone mineral density assessment should be performed systematically in all cirrhotic patients.

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