Serum leptin level and its association with fatigue in patients with chronic hepatitis C virus infection

El-Gindy, Eman M; Ali-Eldin, Fatma A.; Meguid, Marwa Abd El

doi:10.1016/j.ajg.2012.05.001

Cited by 7 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This relationship remained significant ( β = −0.15, P = 0.003) even after adjusting for the statistically significant covariates in our final model. This result does not support our initial hypothesis, in which we predicted that leptin levels would be positively correlated with fatigue levels, as observed in patient cohorts of other disease states …”

Section: Discussioncontrasting

confidence: 97%

“…Leptin is an endocrine hormone that is more commonly known for its metabolic effects, which range from appetite suppression to regulating body weight . Leptin has shown moderate correlations to varying extents with fatigue in cohorts of patients with cardiovascular risk factors (r = 0.22), chronic fatigue syndrome (r = −0.51 to 0.73), chronic hepatitis C infection (r = 0.25; r = 0.30), and irritable bowel syndrome (r = 0.60) . In another study, researchers found that plasma leptin levels could be induced by hydrocortisone, and were markedly increased in patients with chronic fatigue syndrome .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of plasma leptin, pro‐inflammatory adipokines and cancer‐related fatigue in early‐stage breast cancer patients: A prospective cohort study

Toh

Tan

Yeo

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

Cancer‐related fatigue (CRF) is subjective and has wide inter‐individual variability. Given that leptin is commonly associated with fatigue syndrome, its use as a potential biomarker for CRF is being investigated. The primary objective of this study was to evaluate the association between leptin and CRF in early‐stage breast cancer patients receiving chemotherapy. In a prospective cohort study, patients completed assessments at baseline (T1), during chemotherapy (T2) and after chemotherapy (T3). Levels of plasma leptin and adipokines were measured using a Luminex bead‐immunoassay and CRF was measured using the Multi‐Dimensional Fatigue Symptom Inventory‐Short Form (MFSI‐SF). Data were analysed longitudinally using a generalised estimating equation incorporating clinically relevant parameters and pro‐inflammatory adipokines. The analysis included 136 patients (mean age ± SD = 51.5 ± 8.8 years; 69.1% receiving anthracycline‐based chemotherapy). More patients experienced CRF at T3 (23.8%) than at T2 (13.8%) compared to baseline. An increase was observed in the median plasma leptin level at T2, followed by a decrease at T3 (T1: 4.07 ng/mL, T2: 4.95 ng/mL and T3: 3.96 ng/mL). In the multivariate model, the change in leptin levels over time was significantly associated with the total MFSI‐SF score ( β = −0.15, P = 0.003) after adjusting for the tumour necrosis factor‐α (TNF‐α) level, anxiety, depression, insomnia, age, menopausal status and type of chemotherapy. This is the first study to report leptin as a biomarker that predicts the onset of CRF over time. Future studies are required to validate the findings.

show abstract

Section: Discussioncontrasting

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Association of plasma leptin, pro‐inflammatory adipokines and cancer‐related fatigue in early‐stage breast cancer patients: A prospective cohort study

Toh

Tan

Yeo

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Psychological and psychiatric comorbidities as well as old age, being female and single have been important predictors of fatigue in several studies (9, 24, 25). Several biological markers including low serum carnitine, creatinine, and BDNF concentrations (9, 11, 26), and higher serum leptin concentrations (27) also predicted higher fatigue levels in HCV-infected patients. Other biochemical, pathological, and viral parameters are unrelated to fatigue (9, 21, 27, 28).…”

Section: Resultsmentioning

confidence: 99%

“…Several biological markers including low serum carnitine, creatinine, and BDNF concentrations (9, 11, 26), and higher serum leptin concentrations (27) also predicted higher fatigue levels in HCV-infected patients. Other biochemical, pathological, and viral parameters are unrelated to fatigue (9, 21, 27, 28). An important correlate of fatigue in HCV-infected individuals is HCV itself (9, 11).…”

Section: Resultsmentioning

confidence: 99%

Neuropsychiatric and Psychosocial Issues of Patients With Hepatitis C Infection: A Selective Literature Review

2013

View full text Add to dashboard Cite

ContextWe briefly reviewed the evidence on the association of hepatitis C (HCV) infection with several aspects of mental and psychosocial health.Evidence AcquisitionMedline was searched with appropriate keywords. The primary sources were the systematic reviews. If systematic reviews were not available for a subject, then the most relevant and methodologically sound original studies were selected.ResultsHCV infection is associated with poorer health-related quality of life, and physical, mental, and social health. A part of impaired health of these patients is related to cirrhosis, intravenous drug use, co morbid psychiatric disorders, stigmatization, poor social support, alcohol abuse, and interferon treatment. However, HCV itself is also associated with poorer health status particularly in the physical and cognitive domains, which might be related to brain alterations induced by the virus. Interferon treatment is an important cause of depression in HCV patients and sometimes is associated with irritability, manic episode, or acute confusional state. Social health of HCV patients is significantly impaired by stigmatization, poor social support, psychiatric comorbidties, and impaired coping. Psychosocial impairment of HCV patients significantly impairs their treatment adherence. A supportive and nonjudgmental multidisciplinary team is required for optimal management of these patients.ConclusionsPatients with HCV infection had complex neuropsychiatric and psychosocial problems. These problems are challenges for management of HCV infection, affect the patient’s care significantly, and might alter the course of the disease. A multidisciplinary approach, a supportive environment, and a nonjudgmental healthcare team are required for optimal medical and psychosocial management of patients with HCV.

show abstract

“…W badaniu El-Gindy i wsp. [44] dotyczącym pacjentów z PZWC poziom leptyny nie wiązał się z zaawansowaniem niewydolności wątroby ocenianym w skali Child-Pugh, korelował jednak dodatnio z nasileniem zmęczenia. Sporną kwestią jest również zależność nasilenia stłuszczenia wątroby od poziomu leptyny.…”

Section: Leptynaunclassified

Selected adipocytokines and their potential role in the control of the course of chronic hepatitis B and C

Olszok

Wyganowska

Tarabura-Dragon

et al. 2015

Ann. Acad. Med. Siles.

View full text Add to dashboard Cite

Przewlekłe wirusowe zapalenie wątroby (WZW) typu B i C należą do najczęstszych chorób wątroby. Długotrwały proces martwiczo-zapalny może prowadzić do groźnych dla życia powikłań, choć u niektórych pacjentów stan wątroby jest stabilny przez wiele lat. Ze względu na zróżnicowane rokowanie w przebiegu przewlekłego wirusowego zapalenia wątroby (PWZW) typu B i C, poszukuje się obecnie dodatkowych czynników hamujących postęp tych chorób. Obiektem wielu badań stały się adipocytokiny, substancje o wielokierunkowym oddziaływaniu, wytwarzane m.in. przez komórki tkanki tłuszczowej. W pracy przedstawiono wzajemne zależności wybranych adipocytokin i WZW typu B i C oraz potencjalne wykorzystanie tej wiedzy w praktyce lekarskiej.

show abstract

Serum leptin level and its association with fatigue in patients with chronic hepatitis C virus infection

Cited by 7 publications

References 33 publications

Association of plasma leptin, pro‐inflammatory adipokines and cancer‐related fatigue in early‐stage breast cancer patients: A prospective cohort study

Association of plasma leptin, pro‐inflammatory adipokines and cancer‐related fatigue in early‐stage breast cancer patients: A prospective cohort study

Neuropsychiatric and Psychosocial Issues of Patients With Hepatitis C Infection: A Selective Literature Review

Selected adipocytokines and their potential role in the control of the course of chronic hepatitis B and C

Contact Info

Product

Resources

About