Leptin Levels in Various Manifestations of Pulmonary Tuberculosis

Büyükoğlan, Hakan; Gülmez, İnci; Keleştimur, Fahrettin; Kart, Levent; Oymak, Fatma Sema; Demir, Ramazan; Ozesmi, M

doi:10.1155/2007/64859

Cited by 35 publications

(33 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study also suggests that patients with pulmonary tuberculosis exhibited increased leptin levels correlating with increased TNFα levels [33]. It has also been reported that leptin levels are associated with loss of appetite in pulmonary tuberculosis and that plasma leptin levels are significantly suppressed in patients with active pulmonary tuberculosis [14, 34], which is reflected in our data on PTB and LTB alone individuals as well (Table 2). The other adipocytokines like visfatin are also secreted by adipocytes in visceral fat and decrease insulin resistance [35].…”

Section: Discussionsupporting

confidence: 81%

Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines

et al. 2016

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is recognized as major risk factor for the progress of active pulmonary tuberculosis (PTB), although the mechanistic link between diabetes and tuberculosis remains poorly characterized. Moreover, the influence of poorly controlled diabetes on the baseline levels of adipocytokines in the context of tuberculosis has not been explored in detail. To characterize the influence of coexistent DM on adipocytokine levels in pulmonary or latent TB (LTB), we examined circulating levels of adipocytokines in the plasma of individuals with PTB-DM or LTB-DM and compared them with those without DM (PTB or LTB). PTB-DM or LTB-DM is characterized by diminished circulating levels of adiponectin and adipsin and/or heightened circulating levels of leptin, visfatin and PAI-1. In addition, adiponectin and adipsin exhibit a significant negative correlation, whereas with leptin, visfatin and PAI-1 display a significant positive correlation with HbA1C levels and random blood glucose levels. Therefore, our data reveal that PTB-DM or LTB-DM is characterized by alterations in the systemic levels of adipocytokines, indicating that altered adipose tissue inflammation underlying Type 2 diabetes potentially contributes to pathogenesis of TB disease.

show abstract

Section: Discussionsupporting

confidence: 81%

Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The optimal in vitro concentration of leptin for hBD-2 induction (10 ng/ml) is nearly equal to its in vivo serum concentrations [15.74 Ϯ 9.12 ng/ml in healthy adults (51)], though leptin levels in the skin may be lower. However, serum leptin levels and leptin levels at infected sites decline during fasting and are also decreased in malnourished hosts with chronic illnesses, such as cancer or chronic obstructive lung diseases (52,53); moreover, such hosts are more susceptible to infection and delayed wound repair (6,8).…”

Section: Discussionmentioning

confidence: 99%

Leptin Enhances Human β-Defensin-2 Production in Human Keratinocytes

Kanda

Watanabe

2008

Endocrinology

View full text Add to dashboard Cite

Leptin, an adipocyte-derived cytokine/hormone, modulates innate and adaptive immunity. Human ␤-defensin-2 (hBD-2) produced by epidermal keratinocytes promotes cutaneous antimicrobial defense, inflammation, and wound repair. We examined the in vitro effects of leptin on hBD-2 production in human keratinocytes. hBD-2 secretion and mRNA expression were analyzed by ELISA and RT-PCR, respectively. Although leptin alone was ineffective, it enhanced IL-1␤-induced hBD-2 secretion and mRNA expression in keratinocytes. IL-1␤-and IL-1␤ plus leptin-induced hBD-2 production both were suppressed by antisense oligonucleotides against nuclear factor-B (NF-B) p50 and p65; the latter was also suppressed by antisense signal transducer and activator of transcription (STAT)1 and STAT3. IL-1␤ enhanced the transcriptional activity of NF-B, whereas leptin enhanced STAT1 and STAT3 activity. The p38 MAPK inhibitor SB202190 suppressed IL-1␤-and IL-1␤ plus leptin-induced hBD-2 production, IL-1␤-induced NF-B activity, and leptin-induced STAT1 and STAT3 activity; contrastingly, the Janus kinase (JAK) 2 inhibitor AG490 suppressed IL-1␤ plus leptin-induced hBD-2 production and leptin-induced STAT1 and STAT3 activity. IL-1␤ induced serine phosphorylation of inhibitory B␣, STAT1, and STAT3. Leptin induced tyrosine and serine phosphorylation of STAT1 and STAT3, both of which were suppressed by AG490, and serine phosphorylation was also suppressed by SB202190. IL-1␤ or leptin individually induced threonine/tyrosine phosphorylation of p38 MAPK, whereas only leptin induced tyrosine phosphorylation of JAK2, suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-B, which is activated by IL-1␤. Leptin may promote cutaneous antimicrobial defense, inflammation, and wound repair via hBD-2. (Endocrinology 149: 5189 -5198, 2008)

show abstract

“…Low levels of leptin can worsen the prognosis of TB because leptin plays an important role in cellular immunity, the means by which the body attacks Mycobacterium tuberculosis 51012).…”

Section: Introductionmentioning

confidence: 99%

Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children

et al. 2017

View full text Add to dashboard Cite

PurposeTuberculosis (TB) remains a problem in the community. TB patients usually experience malnutrition, which is characterized by both decreased body weight (BW) and body fat percentage (BFP). Leptin, an important regulator of BW, also plays an important role in cellular immunity, which is integral to defense against Mycobacterium tuberculosis infection. We analyzed the effect of an anti-TB treatment regimen on the leptin level, BW, and BFP of children with TB.MethodsThe design of this study was a group interrupted time series. The subjects were children with probable TB according to clinical criteria based on an Indonesian scoring system adopted from the Consensus of Expert Panel. BW; BFP; energy intake; fat and protein intake; and leptin levels before, 2 months after (intensive phase), and 6 months after (continuation phase) anti-TB treatment, were measured. About 40 children, aged 5–14 years, participated in this study.ResultsThe BW, BFP and leptin level increased from before treatment to after completion of the intensive phase and still showed an increased during the continuation phase: BW 18.65 kg, 19.75 kg, and 20.85 kg; BFP 18.3%, 19.5%, and 20.2%; and leptin level 1.9 mg/dL, 3.07 mg/dL, and 3.4 mg/dL, respectively (P<0.01).ConclusionLeptin level, BW, and BFP increased throughout the course of anti-TB treatment, compared with pretreatment values. Further research is needed to compare the results with data for healthy children.

show abstract

Leptin Levels in Various Manifestations of Pulmonary Tuberculosis

Cited by 35 publications

References 34 publications

Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines

Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines

Leptin Enhances Human β-Defensin-2 Production in Human Keratinocytes

Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children

Contact Info

Product

Resources

About