Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children

Mexitalia, Maria; Dewi, Yesi Oktavia; Pramono, Adriyan; Anam, Mohammad Syarofil

doi:10.3345/kjp.2017.60.4.118

Cited by 16 publications

(15 citation statements)

References 23 publications

(47 reference statements)

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“…Similarly, previous reports have also found that ATT is associated with increased systemic levels of leptin in PTB individuals. [26][27][28] Our data confirmed and extended these results and demonstrated that successful completion of ATT (and consequent cure of TB) was associated with elevated levels of leptin.…”

Section: Discussionsupporting

confidence: 82%

Altered Systemic Adipokine Levels in Pulmonary Tuberculosis and Changes following Treatment

Moideen

Kumar

Nair

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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Pulmonary tuberculosis (PTB) is associated with modulation of levels of adipokines, specifically adiponectin and leptin, but the effect of standard antituberculosis treatment (ATT) on the systemic levels of adiponectin, resistin, and leptin has not been well explored. To identify the association of adipokines with PTB and their relationship with disease severity and bacterial burden, we measured the levels of adiponectin, resistin, and leptin in PTB individuals and compared them with latent tuberculosis (LTB) and healthy control (HC) individuals. Pulmonary tuberculosis was characterized by diminished circulating levels of adiponectin and leptin and heightened circulating levels of resistin in comparison to that in LTB and HC individuals. However, PTB with bilateral or cavitary disease did not exhibit any increased systemic levels of these adipokines in comparison with those with unilateral or non-cavitary disease, respectively. In addition, none of the adipokines exhibited a positive correlation with bacterial burdens, but adiponectin alone exhibited a negative correlation with body mass index in PTB individuals. Finally, on successful completion of ATT, PTB individuals exhibited significantly increased levels of adiponectin and leptin and significantly decreased levels of resistin. Therefore, our data identify an important association of systemic adipokine levels with PTB disease and its alteration following ATT.

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Section: Discussionsupporting

confidence: 82%

Altered Systemic Adipokine Levels in Pulmonary Tuberculosis and Changes following Treatment

Moideen

Kumar

Nair

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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“…29 Maxitalia et al reported that the body weight, body fat percentage, and leptin levels were significantly increased at the end of treatment in TB patients that had presented with mild chronic malnutrition at the time of diagnosis. 30 To the best of our knowledge, our study is the first to address malnutrition among pediatric TB cases in Turkey. In this study, although we observed clinical improvement at the end of treatment, mild or moderate malnutrition continued.…”

Section: Discussionmentioning

confidence: 93%

Clinical and Laboratory Evaluation of Pediatric Tuberculosis Cases in Light of Nutritional Indicators

Tezol¹,

Alakaya²,

Akar³

et al. 2019

Ankara Medical Journal

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Objectives: Pediatric tuberculosis is a major public health problem. Malnutrition characterized with wasting is prevalent among pediatric tuberculosis patients. We aimed to review pediatric tuberculosis cases by considering their nutrition manifestations. Materials and Methods:The study evaluated demographical, clinical, anthropometric, microbiological, histopathological and radiological characteristics of tuberculosis patients, retrospectively. Results:The study involved 77 tuberculosis cases. Sixty-three percent of the patients were male with a mean age of 9.32±4.91 years. Twenty-four patients (31%) diagnosed with definite tuberculosis, thirtynine patients (50%) with probable tuberculosis, and fourteen patients (18%) with latent tuberculosis infection. Acid resistant bacteria were observed in 33%, culture positivity was observed in 20%, both acid resistant bacteria and culture positivity was observed in 45% of definite diagnosed group. Forty percent of patients had pulmonary, 32% had extrapulmonary, 6% had miliary, 2% had both pulmonary and extrapulmonary tuberculosis. Pulmonary tuberculosis diagnosed patients were significantly older than extrapulmonary plus miliary group (p=0.003). Culture positivity rate was significantly higher in pulmonary, diagnostic histopathological sampling rate was significantly higher in extrapulmonary plus miliary group (p=0.019, p=0.012). Thirty seven percent of patients had a contact history, 23% of those had household contact, and the most common index cases were fathers. The tuberculin test was positive in 11 patients (45%) with definite and 15 patients (38%) with probable tuberculosis. No significant difference has been observed between definite and probable tuberculosis groups according to the sex, average age, symptom duration, tuberculin test positivity, Bacille Calmette-Guerin vaccine scar presence, contact history rate, hematologic tests, and anthropometric measurements (p>0.05). At the time of diagnosis mean (SD) values of height for age and weight for height medians [ 94.35 (7.50) % and 85.72 (6.92) %, respectively] refered to mild malnutrition, the same conditions were remaining at the end of treatment. When height for age taken into consideration the chronic malnutrated group was probable tuberculosis group. Weight for height (for <5 years old cases) and body mass index (for ≥5 years old cases) Z scores of sixteen patients were less than -2 SD value and these moderae malnutrated cases were remaining at the end of treatment. There was not a statistical significance between anthropometric measurements at the time of diagnosis and at the end of antituberculosis treatment (p>0.05). Conclusion: Nutrition status monitoring, correcting nutritional deficiencies and failures can be neglected in course of antituberculosis treatment. Tuberculosis management should be integrated with malnutrition monitoring in pediatric cases.

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“…Leptin is thought to be a mediator in the complex process between TB, nutrition status and host immune response. Leptin level increment in the body is correlated to increment energy, protein and fat intake which is increased after administration of oral anti-tuberculosis therapy either in intensive phase or maintenance phase [8]. Thus, the more energy intake will increase body weight during and after tuberculosis therapy.…”

Section: Discussionmentioning

confidence: 99%

The Body Weights’ Follow Up Before and After 6 Months Therapy of Oral Anti-Tuberculosis Therapy in Children in Medan, Sumatra Utara

Airlangga¹,

Araf²

2019

Open Access Maced J Med Sci

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BACKGROUND: Tuberculosis remains an important issue of children health, particularly in developing countries. Body Weight is one of the tuberculosis symptoms and used to identified children tuberculosis scoring in Indonesia. AIM: The study aims to get an overview of body weight and body weight increment during oral anti-tuberculosis in Medan, Sumatra Utara. METHODS: Medical records of children with tuberculosis in the Haji Hospital of Sumatra Utara located in Medan during January 2018 till July 2018 were compiled for the children characteristic, body weight before and after oral anti-tuberculosis treatment. RESULTS: There were 99 children medical records included in the study, 42.4% children 1 to 5 years old treated as tuberculosis. At the early treatment, many children were in severe malnutrition (85%). However, after 6 months of tuberculosis treatment, there were many children (78%) got their body weight increment. CONCLUSION: Body weight is an important sign and symptom of children with tuberculosis.

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Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children

Cited by 16 publications

References 23 publications

Altered Systemic Adipokine Levels in Pulmonary Tuberculosis and Changes following Treatment

Altered Systemic Adipokine Levels in Pulmonary Tuberculosis and Changes following Treatment

Clinical and Laboratory Evaluation of Pediatric Tuberculosis Cases in Light of Nutritional Indicators

The Body Weights’ Follow Up Before and After 6 Months Therapy of Oral Anti-Tuberculosis Therapy in Children in Medan, Sumatra Utara

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