Leptin levels at birth and in early postnatal life in small- and appropriate-for-gestational-age infants

Valūnienė, Margarita; Verkauskienė, Rasa; Boguszewski, Margaret Cristina da Silva; Dahlgren, Jovanna; Lašienė, Danutė Teresė; Lašas, Liudvikas; Wikland, Kerstin Albertsson

doi:10.3390/medicina43100100

Cited by 46 publications

(60 citation statements)

References 34 publications

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“…Additionally, leptin was significantly lower in mothers who delivered preterm vs term babies [26]. Some studies showed that cord blood leptin levels were positively correlated with maternal BMI, neonatal adiposity, fetal growth indeces and placental weight [7,27,28]. In this study, we observed a positive correlation between leptin levels in cord blood and newborn health outcomes (weight, height and head circumference z scores) in the control group.…”

Section: Discussionsupporting

confidence: 66%

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Effects of maternal intake of n-3 fatty acids on lipid profile and leptin concentration in cord blood

Batirel¹,

Büyükuslu²,

Bekiroğlu³

et al. 2017

Marmara Medical Journal

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Anne tarafından alınan n-3 yağ asitlerinin kordon kanı lipid profiline ve leptin konsantrasyonuna etkisi ÖZ Amaç: Anne tarafından, n-3 uzun zincirli çoklu doymamış yağ asit (UZ-ÇDYA)'lerinin alımı, fetal gelişim ve hamilelik sonuçları üzerine pozitif etkilidir. Leptin, UZ-ÇDYA'larının plasentadan geçişinde önemli bir rol alır. Bu çalışmada, anne tarafından alınan UZ-ÇDYA'larının, anne ve yenidoğanın antropometrik ölçümlerine, kordon kanındaki yağ asitlerine ve leptin düzeylerine olan etkilerini araştırmayı amaçladık.Gereç ve Yöntem: Çalışmaya 31 hamile kadın dahil edildi. Bunların 18'i kontrol grubuna alınırken 13'ü hamileliklerinin son trimesteri boyunca, n-3 UZ-ÇDYA içeren bir ilaç aldı (ilaçlı grup). Katılımcıların fizik muayeneleri yapıldı ve bir anket yardımıyla ek veriler elde edildi. Kordon kanındaki yağ asitleri ve leptin konsantrasyonları, sırasıyla gaz kromatograf kütle spektrometri (GC-MS) ve enzim bağlantılı immunosorbent test (ELISA) kiti kullanılarak analiz edildi.Bulgular: Toplam n-3 ÇDYA'ların miktarı ilaç kullanımıyla anlamlı olarak arttı. İlaçlı grupta n-6/n-3 ÇDYA'larının oranı ve leptin düzeyleri daha düşüktü (P=0,052, P=0,140 sırasıyla). Kontrol grubunda, leptin düzeyleri ile yeni doğanların doğum kilosu, boyu ve baş çevresi arasında pozitif ilişki vardı. İlaç kullanımı, leptin konsantrasyonlarını, n-6/n-3 ÇDYA oranları ile pozitif ilişkili hale getirdi.Sonuç: Günlük n-3 UZ-ÇDYA'larının alımı, anne ve yeni doğan sağlığının iyileşmesinde etkili olabilir.

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Section: Discussionsupporting

confidence: 66%

“…This might be caused by increased adipose depots and increased synthesis by the placenta. It is observed that umbilical leptin concentration is correlated with pregnancy outcomes and play a key role in fetal development [7][8].…”

Section: Introductionmentioning

confidence: 99%

Effects of maternal intake of n-3 fatty acids on lipid profile and leptin concentration in cord blood

Batirel¹,

Büyükuslu²,

Bekiroğlu³

et al. 2017

Marmara Medical Journal

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“…Nepakankama vaisiaus mityba lemia sumažėjusią IGF-1 koncentraciją virkštelės kraujyje (22)(23)(24)(25). Daugelio tyrimų duomenimis, yra tiesioginis teigiamas ryšys tarp naujagimių antropometrinių parametrų ir IGF-1, IGF-surišančio baltymo-3 (IGFBP-3) bei leptino koncentracijų virkštelės kraujyje (23)(24)(25)(26)(27)(28)(29). Pastebėta, jog leptino kiekis virkštelės kraujyje yra tiesiogiai proporcingas gimimo svoriui ir atvirkščiai proporcingas svorio prieaugiui pirmaisiais gyvenimo metais (29)(30)(31)(32).…”

Section: įVadasunclassified

“…Tačiau diskusijų objektu išlieka naujagimių augimo faktorių bei leptino koncentracijų įtaka tolesniam ponataliniam augimui (22)(23)(24)(25)(26)(27)(28)31). Be to, išvadoms, suformuluotoms iš stebimųjų ir didžiąja dalimi retrospektyviųjų tyrimų duomenų, todėl reikalinga laiko sąlygota kritinė interpretacija (1)(2)(3)(4)(5)19).…”

Section: įVadasunclassified

“…Maža MGA vaikų virkštelės leptino koncentracija didžiąja dalimi yra sąlygota mažo riebalinio audinio sankaupų intrauteriniu laikotarpiu (28,32). Taikant linijinės regresijos metodą, rastas atvirkštinis ryšys tarp leptino kiekio virkštelės kraujyje ir ponatalinio augimo pirmaisiais gyvenimo metais tik mažų pagal gestacijos amžių vaikų grupėje.…”

Section: Log Leptinasunclassified

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Postnatal growth in children born small and appropriate for gestational age during the first years of life

Valūnienė¹,

Danylaitė²,

Kryžiūtė³

et al. 2008

Medicina

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Bioactive peptides in preterm human milk: Impact of maternal characteristics and their association to neonatal outcomes

et al. 2023

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Human milk adipokines in term babies seem partially determined by maternal factors and affect infant's development. We aimed to describe bioactive peptide concentration in very preterm human milk and associations to maternal characteristics and postnatal growth. Mothers delivering ≤32 weeks of gestation and their infant/s were recruited. At 4 weeks of lactation, an aliquot of 24‐h‐pooled milk was collected for exclusively breastfeeding dyads. Insulin, leptin, adiponectin, and milk fat globule epidermal growth factor‐8 (MFG‐E8) were measured by enzyme‐linked immunoabsorbent assay in skimmed milk. One hundred mothers (28.8 ± 2.3 weeks at delivery) provided a milk sample. Milk insulin was related to gestational age, pre‐pregnancy body mass index (BMI), and galactagogue treatment (final model: adjusted R2: 0.330, p < 0.0001; adjusted β coefficients: galactagogue treatment: 0.348, p 0.001; pre‐pregnancy BMI: 0.274, p 0.009; gestational age: −0.290, p 0.007). Adiponectin was higher in mothers with gestational diabetes (30.7 ± 6.5 vs. 24.8 ± 8 ng/mL, p 0.044). Leptin was associated with pre‐pregnancy BMI (Spearman's ρ: 0.648, p < 0.0001) and MFG‐E8 to presence of labor and multiple pregnancy (final linear regression model, R2: 0.073, p 0.028, adjusted β coefficients: presence of labor −0.229, p 0.050; twins: −0.192, p 0.099). Milk adiponectin was associated with a greater decrease in length z‐scores from birth to 28 days (Pearson's r: −0.225, p 0.032) and to discharge (Pearson's r: −0.290, p 0.003). Milk MFG‐E8 was lower in milk of mothers whose babies experienced late‐onset sepsis (13.3 ± 5.8 vs. 16.8 ± 6.3 μg/mL, p 0.023). Adipokines levels in preterm human milk are partially related to maternal metabolic status. Milk peptide concentration associates with early neonatal growth trajectories.

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Leptin levels at birth and in early postnatal life in small- and appropriate-for-gestational-age infants

Abstract: Summary. The aim of this study was to evaluate leptin concentration at birth and in early

Cited by 46 publications

References 34 publications

Effects of maternal intake of n-3 fatty acids on lipid profile and leptin concentration in cord blood

Effects of maternal intake of n-3 fatty acids on lipid profile and leptin concentration in cord blood

Postnatal growth in children born small and appropriate for gestational age during the first years of life

Bioactive peptides in preterm human milk: Impact of maternal characteristics and their association to neonatal outcomes

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