Leptin Inhibits the Apoptosis of Endometrial Carcinoma Cells Through Activation of the Nuclear Factor κB–inducing Kinase/IκB Kinase Pathway

Zhou, Xi; Li, Hui; Chai, Ying; Li, Zi

doi:10.1097/igc.0000000000000440

Cited by 23 publications

(26 citation statements)

References 38 publications

(36 reference statements)

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“…In their meta-analysis, Wang et al 15 concluded that elevated leptin concentration might constitute an independent risk factor for endometrial cancer. Zhou et al 16 obtained similar results on endometrial cancer cell lines, reporting greater leptin expression in poorly differentiated endometrial cancer cells. In this present study, leptin caused partial inhibition of apoptosis through activation of the NIK/IKK pathway.…”

Section: Discussionmentioning

confidence: 70%

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Evaluation of biologically active substances promoting the development of or protecting against endometrial cancer

Cymbaluk‐Płoska¹,

Chudecka‐Głaz²,

Jagodzińska³

et al. 2018

OTT

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IntroductionAdipose tissue is considered an endocrine organ and produces a number of biologically active substances.AimsTo consider the role that four adipokines – leptin, omentin-1, vaspin, and galectin-3 – play in the diagnosis of endometrium cancer and to investigate the association between serum concentrations of adipose tissue metabolism products and the diagnostics and prognosis in endometrial cancer.Patients and methodsThe study included 168 patients with body mass index (BMI) >20 kg/m2 admitted due to post-menopausal bleeding.ResultsA receiver operating characteristic curves test was performed to determine the diagnostic values of the proteins tested. For leptin and galectin-3 the area under the curve (AUC) values were 0.79/0.68, while for vaspin and omentin-1 the AUC values were 0.82/0.86 for all study patients. The final model identified the following independent risk factors: glucose concentration, BMI, waist circumference, leptin, and vaspin concentrations. Diagnostic values of leptin and galectin-3 with regard to differentiation between high (Fédération Internationale de Gynécologie Obstétrique [FIGO] III and IV) and low (FIGO I and II) stages of clinical tumor advancement and prediction of tumor grading (G1 vs G3) based on the AUC curve were 0.82/0.70 and 0.80/0.74. The AUC values for vaspin and omentin-1 with respect to differentiation between histopathological advancement and grading were 0.86/0.81 and 0.83/0.77, respectively. Significantly lower values of mean omentin-1 and vaspin concentrations were also demonstrated in cases of lymphatic vessel invasion, lymph node metastases, or deep endometrial infiltration (p=0.002, p=0.01, p=0.003, respectively).ConclusionIt appears that elevated concentrations of leptin, vaspin, and omentin-1 may indicate the presence of endometrial cancer. Furthermore, leptin serum level and vaspin appear to be useful tools in the assessment of clinical staging of endometrial cancer.

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Section: Discussionmentioning

confidence: 70%

“…Some studies, for example, the Zhou et al study, report overexpression of leptin receptor Ob-Rb in endometrial cancer. 16 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of biologically active substances promoting the development of or protecting against endometrial cancer

Cymbaluk‐Płoska¹,

Chudecka‐Głaz²,

Jagodzińska³

et al. 2018

OTT

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“…Several serological studies stated evidences that elevated leptin concentration in serum is correlated with breast cancer risk and counted it as an independent risk factor, in addition to its involvement in many malignancy stages including as cell growth, invasion, migration, metastases, recurrence and therapy response in some organs such as liver [ 17 ], lung [ 18 ], stomach [ 19 ], thyroid [ 20 ], uterus [ 12 ], colon [ 21 ]. A number of investigations were launched to identify the mechanisms which link leptin with tumor growth and progression of breast cancer [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer

et al. 2017

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BackgroundObesity is part of the established risk factors for breast cancer (BC) in postmenopausal females. Circulating leptin increases in parallel with the increase of body weight and fat reservoir.MethodsThis research investigated the link between leptin phenotype and the clinicopathological factors in BC. A large set of breast cancer cases (449), and 27 non-cancerous tissue samples of breast were employed for leptin expression recognition using immunohistochemistry staining.ResultsCytoplasmic immunohistochemical staining of leptin was recognized in 376 (83.7%) and 25 (92.6%) of BC and control cases respectively. Leptin immunostaining were significantly associated with age, histotypes, grade, stage, lymph node involvement, tumor recurrence, hormone receptor phenotypes, ER and HER2 expressions, and p-values were (P = 0.0233), (P = 0.0001), (P = 0.050), (P = 0.0291), (P = 0.0300), (P = 0.0023), (P = 0.0021), (P = 0.0279) respectively. Reasonable proportion of cases with low staining score was more prevalent in all subgroups of clinicopathological parameters except ER- PR+ HER2- hormone receptor phenotype and mucinous carcinoma which showed high level of leptin immunoreactivity. Tumor recurrence is less prevailing in high score leptin immunostaining cases. Furthermore, Log Rank (Mantel-Cox) test findings revealed considerably different survival distributions were observed for the different categories of leptin immunostaining scores (P = 0.032). Negative leptin immunostaining is related to poor survival.ConclusionsOur preliminary findings support leptin clinical value in confirming BC diagnosis as well as prognosis. These results suggest that leptin molecule is an important biomarker that could identify type, grade, stage, lymph node involvement, relapse and prognosis in breast cancer.

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“…[ 7 – 9 ] Several reports have described leptin role in the proliferation, migration, and invasion of tumor cells and how it prevents apoptosis through different ways. [ 10 – 14 ] Histologically, many studies have attempted to test the relationship between leptin immunoexpression and clinical parameters in several tumors including colorectal cancer, but the findings are controversial, [ 15 – 25 ] and yet, not much is known about the clinical significance of leptin phenotype in colorectal carcinomas. Thus, the present study investigates the immunohistochemical staining of leptin in colorectal cancer, and assesses the correlation of its expression with the clinical characteristics and follow up information of these neoplasms.…”

Section: Introductionmentioning

confidence: 99%

Expression of leptin in colorectal adenocarcinoma showed significant different survival patterns associated with tumor size, lymphovascular invasion, distant metastasis, local recurrence, and relapse of disease in the western province of Saudi Arabia

Al-Maghrabi

Qureshi²,

Khabaz³

2018

Medicine

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Leptin phenotype has been suggested to be a possible biomarker for the diagnosis and prognosis of different neoplasms. Nonetheless, there are conflicts among the outcomes found in several tumors, and little is proven concerning the correlation between the phenotype of leptin and its clinical significance in colorectal carcinomas. This study will describe the phenotype of leptin in colorectal adenocarcinomas, and investigate its correlation with clinicopathological factors.Two hundred and twenty eight tissue samples include 155 colorectal carcinomas, 40 adenomas, and 33 noncancerous cases were utilized in constructing tissue microarrays which have been used in the revealing of leptin expression using leptin monoclonal antibody and immunohistochemistry staining protocol.Immunoexpression of leptin was recognized in 145 (93.5%) of colorectal tumors and 56 (76.7%) cases of control group. Histotype was considerably associated with leptin phenotype (P = .000), there is up regulation in leptin expression in colorectal carcinoma cases. Significantly higher proportion of negative leptin immunostaining cases were observed in tumors which have size more than 5 cm (P = .045). Whereas, significant different survival patterns were observed in positive cases regarding tumor size, lymphovascular invasion, distant metastasis, local recurrence and relapse of disease (P-values .046, .011, .000, .013, and .001, respectively). On the other hand, positive leptin staining colorectal tumors with size <5 cm, and with no distant metastases, local recurrence, or disease relapse had significantly better survival estimates. However, leptin immunostaining did not show noteworthy associations with age, gender, differentiation, tumor location, stage, margins involvement, lymphovascular invasion, and lymph node metastasis.The current study shows up regulation in leptin expression in colorectal adenocarcinoma compared with noncancerous control cases. Thus, immunohistochemical staining of leptin in colorectal cancer could be a helpful tool in the prediction of prognosis and survival pattern of colorectal cancer with certain clinicopathological factors (tumor size, lymphovascular invasion, distant metastasis, local recurrence, and relapse of disease).

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Leptin Inhibits the Apoptosis of Endometrial Carcinoma Cells Through Activation of the Nuclear Factor κB–inducing Kinase/IκB Kinase Pathway

Abstract: Leptin inhibits EC apoptosis partly through activation of the NIK/IKK pathway in vitro. Ob-Rb overexpression seems to facilitate EC progression.

Cited by 23 publications

References 38 publications

Evaluation of biologically active substances promoting the development of or protecting against endometrial cancer

Evaluation of biologically active substances promoting the development of or protecting against endometrial cancer

Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer

Expression of leptin in colorectal adenocarcinoma showed significant different survival patterns associated with tumor size, lymphovascular invasion, distant metastasis, local recurrence, and relapse of disease in the western province of Saudi Arabia

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