Leptin in human pregnancy: The relationship with gestational hormones

Sivan, Eyal; Whittaker, P. G.; Sinha, Deepankar; Homko, Carol J.; Lin, Mimi T.; Reece, E. Albert; Boden, Guenther

doi:10.1016/s0002-9378(98)70118-8

Cited by 134 publications

(98 citation statements)

References 16 publications

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“…Our finding of elevated leptin in pregnancy may be due to increased secretion from adipocytes in the presence of elevated oestrogen [23] and placental production [24], and is consistent with previous reports [15,25]. We observed reduced leptin levels in GDM compared to that in control subjects.…”

Section: Adipocytokine and Crp Levels In Pregnancy And Postpartumsupporting

confidence: 93%

Do adiponectin, TNFα, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy

McLachlan

O’Neal

Jenkins

et al. 2005

Diabetes Metabolism Res

158

122

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Section: Adipocytokine and Crp Levels In Pregnancy And Postpartumsupporting

confidence: 93%

Do adiponectin, TNFα, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy

McLachlan

O’Neal

Jenkins

et al. 2005

Diabetes Metabolism Res

158

122

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“…Leptin has been shown to affect the reproductive axis in various ways. Studies have documented leptin's importance in initiating puberty, and its important relationship with gonadotropins and other hormones [1][2][3]. Leptin has been found in reproductive tissues to include the placenta, endometrium and ovary [3].…”

Section: Introductionmentioning

confidence: 99%

“…Studies have documented leptin's importance in initiating puberty, and its important relationship with gonadotropins and other hormones [1][2][3]. Leptin has been found in reproductive tissues to include the placenta, endometrium and ovary [3]. Recently, serum leptin levels were demonstrated to fluctuate in a manner similar to other hormones of the female reproductive axis [4].…”

Section: Introductionmentioning

confidence: 99%

The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle

Hill

Uyehara

Hashiro

et al. 2007

J Assist Reprod Genet

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Purpose: To prospectively evaluate serum and follicular fluid leptin, estradiol, and progesterone levels during in vitro fertilization.Methods: Prospective observational study measuring serum levels at six points during the IVF cycle and follicular fluid at the time of retrieval.Results: Serum leptin and estradiol levels both significantly increased for the individual patients during the IVF stimulation process. None of the leptin levels differed based on pregnancy outcome. BMI significantly correlated with all leptin levels. Follicular fluid estradiol correlated with serum estradiol only in pregnant patients (r = 0.97, p < 0.01) and was unrelated in non-pregnant patients (r = − 0.15, p = 0.81).Conclusion: Serum and follicular leptin levels are highly correlated. Leptin levels increase during the IVF cycle and vary between patients based on maternal BMI, but do not correlate with other serum hormone levels or pregnancy outcome. Pregnancy outcome success was reflected in the relationship between follicular fluid and serum levels of estradiol, independent of leptin levels.

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“…Considering the fast increase in leptin concentration during the ®rst weeks of pregnancy, other sources of leptin might be involved. According to Sivan and colleagues (Sivan et al, 1998), hormones like human chorionic gonadotropin (produced by the conceptus during early pregnancy) may stimulate the release of leptin from maternal adipocytes and contribute to the hyperleptinemia.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated that, aside from adipose tissue, the human placenta also synthesizes leptin (Masuzaki et al, 1997;Sen Äaris et al, 1997). Hormones like human chorionic gonadotrophin (hCG), luteinizing hormone (LH), estradiol and insulin may promote leptin release from maternal adipocytes and contribute to the hyperleptinemia (Hardie et al, 1997;Lepercq et al, 1998;Licinio et al, 1998;Sivan et al, 1998). The exact role of this hyperleptinemia during pregnancy is not understood.…”

Section: Introductionmentioning

confidence: 99%

Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation

Rump

Otto

Hornstra³

2001

Eur J Clin Nutr

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Background: The n-3 fatty acid status changes during pregnancy and lactation. Plasma leptin concentrations and gene expression have been related to n-3 fatty acids. Objective: To investigate the relation between plasma leptin concentration and the docosahexaenoic acid (22:6n-3) content of plasma phospholipids during early pregnancy and the postpartum period. Design: Leptin (radioimmunoassay) and the phospholipid fatty acid pro®le (capillary gas-liquid chromatography) were measured in plasma of women during two independent longitudinal observational studies. Dietary intake of n-3 fatty acids was also determined. Results: Within the ®rst 10 weeks after the last menstrual period, an almost parallel increase in leptin concentration and the 22:6n-3 content (mgal and % wtawt) of plasma phospholipids was seen (study 1, n 21). During the postpartum period (study 2, n 57), leptin levels decreased quickly, preceding the changes in 22:6n-3 concentrations. During both studies, leptin concentrations did not consistently relate to dietary intake of n-3 fatty acids or to 22:6n-3 concentrations in plasma phospholipids. Before and during early pregnancy (study 1), signi®cant positive associations between leptin levels and the total amount of phospholipid-associated fatty acids were found. No such association was seen during late pregnancy or the postpartum period (study 2). The postpartum decrease in leptin levels did not differ between lactating and non-lactating women. Conclusions: Not the 22:6n-3 content, but the total amount of phospholipid-associated fatty acids was related to plasma leptin concentration, before and during early pregnancy but not during late pregnancy and the postpartum period. Sponsorship: Dutch Organization for Scienti®c Research (NWO, grant no. 904 62 186).

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Leptin in human pregnancy: The relationship with gestational hormones

Cited by 134 publications

References 16 publications

Do adiponectin, TNFα, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy

Do adiponectin, TNFα, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy

The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle

Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation

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