Do adiponectin, TNFα, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy

McLachlan, Kylie; O’Neal, David N; Jenkins, Alicia J.; Alford, F. P.

doi:10.1002/dmrr.591

Cited by 163 publications

(155 citation statements)

References 46 publications

(67 reference statements)

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“…However, these correlations were lost in the pregnant subjects; in accordance to our study, McLachlan et al (25) found no correlation between adiponectin and insulin sensitivity, as estimated by intravenous glucose tolerance test (IVGTT), in 19 older Australian pregnant women with higher BMI; on the other hand, in contrast to our study, in 219 Asian pregnant women of similar BMI, adiponectin was negatively correlated to insulin and indirect IR parameters during oral GTT (26). Differences in sample size, race, or methodology could be responsible for this discrepancy.…”

Section: Discussionsupporting

confidence: 92%

Serum vaspin levels in normal pregnancy in comparison with non-pregnant women

Giomisi

Kourtis

Toulis

et al. 2011

European Journal of Endocrinology

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Objective: Pregnancy represents a state of insulin resistance (IR). Vaspin (SERPINA12) is a novel insulin-sensitizing adipokine that might be implicated in endogenous glucose regulation. However, its role in pregnancy and its circulating levels have not been adequately studied. We aimed to evaluate serum vaspin levels in pregnancy and their correlation with known markers of IR. Design: A group of 106 women (age 27.9G0.4 years) at the 24-30th week of gestation (pregnancy group) and another 106 age-matched healthy non-pregnant controls (control group) were included in the study. Methods: Serum glucose, insulin, vaspin, adiponectin, and lipid parameters were measured. The quantitative insulin sensitivity check index (QUICKI) was used as an insulin sensitivity index. Results: Pregnant women had significantly higher body mass index (BMI), lipids, and serum insulin and lower serum glucose and vaspin levels than controls. Vaspin was positively correlated to adiponectin in both groups (P!0.001 and P!0.004 respectively) but was not correlated to BMI, serum insulin levels, or the QUICKI index in either group. Furthermore, vaspin was negatively correlated to lipid parameters (total cholesterol, triglycerides, and low-density lipoproteins) in the pregnant but not in the non-pregnant women. Conclusions: Vaspin cannot serve as a marker of IR in either pregnant or non-pregnant women, although it is significantly correlated with adiponectin. On the other hand, vaspin might be useful as a surrogate marker of lipid metabolism in pregnancy if confirmed by subsequent studies.

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Section: Discussionsupporting

confidence: 92%

Serum vaspin levels in normal pregnancy in comparison with non-pregnant women

Giomisi

Kourtis

Toulis

et al. 2011

European Journal of Endocrinology

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“…This observation is consistent with studies showing an increase in plasma TNF-in late pregnancy (Kirwan et al, 2002;Clapp & Kiess, 2000;Boyd et al, 2007). TNF-correlates inversely with insulin secretion in normal pregnancy and was significantly higher in GDM group (McLachlan et al, 2006). TNF-alpha mRNA and protein are present in human placenta and uterine cells at both early and late stages of gestation (Chen et al, 1991).…”

Section: Tumor Necrosis Factor-α (Tnf-α)supporting

confidence: 88%

Pathophysiology of Gestational Diabetes Mellitus: The Past, the Present and the Future

Al-Noaemi¹,

Shalayel²

2011

Gestational Diabetes

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“…Recently, it was shown that serum hsCRP decreased while TNFalpha and adiponectin levels remained unchanged four months postpartum in pregnancies with and without GDM. 39 On the other hand, other investigators found hypoadiponectinemia during the 3 rd and 4 th day postpartum in normal lactating women. 40,18 It has been suggested that this hypoadiponectinemia might be due to the suppression of adipocyte-produced adiponectin by prolactin.…”

Section: Discussionmentioning

confidence: 94%

Pre- and early post-partum adiponectin and Interleukin-1beta levels in women with and without gestational diabetes

Vitoratos¹,

Valsamakis²,

Mastorakos³

et al. 2008

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OBJECTIVE: To investigate maternal serum adiponectin and Ιnterleukin-1beta (IL-1β) levels during the pre-and post-partum periods in pregnant women with and without Gestational Diabetes Mellitus (GDM). DESIGN: Thirty control pregnant Caucasian women without GDM and thirty Body Mass Index (BMI) and age-matched Caucasian women with GDM examined in the outpatient clinic between the 24 th and 26 th week of their pregnancy and on the 3 rd day postpartum underwent anthropometry and had serum blood taken. Both groups, were monitored by a dietitian and had comparable weight gain during pregnancy. Birth weight was also measured. RESULTS: At the 3 rd day postpartum, compared to the 2 nd trimester of pregnancy, women with GDM had lower serum adiponectin levels, lower serum IL-1β levels and lower Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) values. At the 2 nd trimester of pregnancy, women with GDM had lower serum adiponectin levels, higher IL-1β and higher HOMA-IR values compared to women without GDM. At the 3 rd day postpartum, women with GDM had lower serum adiponectin levels, higher IL-1β and higher HOMA-IR values compared to women without GDM. Second trimester serum adiponectin values of women with GDM correlated negatively with birth weight. CONCLUSIONS: Gestational diabetes is a state of insulin resistance associated with altered levels of proinflammatory cytokines, increased IL-1β and decreased adiponectin values. Both of these alterations might be attributed to placental pathology in pregnancies with GDM.

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Do adiponectin, TNFα, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy

Cited by 163 publications

References 46 publications

Serum vaspin levels in normal pregnancy in comparison with non-pregnant women

Serum vaspin levels in normal pregnancy in comparison with non-pregnant women

Pathophysiology of Gestational Diabetes Mellitus: The Past, the Present and the Future

Pre- and early post-partum adiponectin and Interleukin-1beta levels in women with and without gestational diabetes

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