Leptin in bipolar disorder: A systematic review and meta-analysis

Fernandes, Brisa S.; Dash, Sarah; Jacka, Felice N.; Dodd, Seetal; Carvalho, AF; Köhler, CA; Steiner, Johann; Cantarelli, Maria da Graça; Nardin, Patrícia; Ca, Gonçalves; Berk, Michael

doi:10.1016/j.eurpsy.2016.02.003

Cited by 34 publications

(26 citation statements)

References 41 publications

(83 reference statements)

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“…Cytokines secreted by adipose tissue are called adipokines. Dysregulation of adipokines has been linked to many disease states such as diabetes and obesity [11] and also to cardiovascular diseases [23], bone diseases [24], carcinogenesis [25], chronic kidney disease [26], sepsis [27], and even bipolar disorder [28]. Remarkably, in our cohorts of critically ill patients due to sepsis and different entities like cardiogenic shock and liver failure, adipokines like adiponectin [29], resistin [18], and leptin [4] have been shown to associate with patient survival, underlining a critical role of adipokines in the progression of sepsis and nonseptic critical illness.…”

Section: Discussionmentioning

confidence: 99%

Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients

et al. 2016

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Introduction. Omentin, a recently described adipokine, was shown to be involved in the pathophysiology of inflammatory and infectious diseases. However, its role in critical illness and sepsis is currently unknown. Materials and Methods. Omentin serum concentrations were measured in 117 ICU-patients (84 with septic and 33 with nonseptic disease etiology) admitted to the medical ICU. Results were compared with 50 healthy controls. Results. Omentin serum levels of critically ill patients at admission to the ICU or after 72 hours of ICU treatment were similar compared to healthy controls. Moreover, circulating omentin levels were independent of sepsis and etiology of critical illness. Notably, serum concentrations of omentin could not be linked to concentrations of inflammatory cytokines or routinely used sepsis markers. While serum levels of omentin were not predictive for short term survival during ICU treatment, low omentin concentrations were an independent predictor of patients' overall survival. Omentin levels strongly correlated with that of other adipokines (e.g., leptin receptor or adiponectin), which have also been identified as prognostic markers in critical illness. Conclusions. Although circulating omentin levels did not differ between ICU-patients and controls, elevated omentin levels were predictive for an impaired patients' long term survival.

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Section: Discussionmentioning

confidence: 99%

Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients

et al. 2016

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“…Some other studies showed that leptin levels are increased in major depressive disorders, but only in patients experiencing atypical features, suggesting that leptin may be involved in a subset of patients with increased weight [62,63]. Concerning bipolar disorder, a meta-analysis conducted in 2016, including eleven studies and 1118 participants, provides evidence that leptin levels are not altered in BD when compared to healthy controls [64].…”

Section: Leptin and Psychiatric Illnessesmentioning

confidence: 99%

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

et al. 2020

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Antipsychotic-induced weight gain is the most prevalent somatic adverse event occurring in patients treated by antipsychotics, especially atypical antipsychotics. It is of particular interest because of its repercussion on cardiovascular morbidity and mortality especially now that the use of second-generation antipsychotics has been extended to other mental health illnesses such as bipolar disorders and major depressive disorder. The mechanism underlying antipsychotics-induced weight gain is still poorly understood despite a significant amount of work on the topic. Recently, there has been an ongoing debate of tremendous research interest on the relationship between antipsychotic-induced weight gain and body weight regulatory hormones such as leptin. Given that, researchers have brought to light the question of leptin's role in antipsychotic-induced weight gain. Here we summarize and discuss the existing evidence on the link between leptin and weight gain related to antipsychotic drugs, especially atypical antipsychotics.

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“… 3 Its role in obesity and reproductive regulation are well known. 4 It appears to function as regulator of food quantity consumed relative to the amount of energy expended. 5 …”

Section: Introductionmentioning

confidence: 99%

Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques

et al. 2018

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Background & objective:Leptin facilitates onset of puberty by impact on hypothalamic Kisspeptin, gonadotropin releasing hormone, follicle stimulating and luteinizing hormone. The link of peripheral Leptin-Kisspeptin in regulating the ovarian and endometrial tissue in relation to adiposity is unknown. Therefore, we wanted to identify Kisspeptin-Leptin association with body mass index (BMI) and success of assisted reproductive treatments (ART) in infertile females.Methods:A cross sectional study was carried from August 2014 till May 2016 after receiving ethical approval at Australian Concept Infertility Medical Centre, and Aga Khan University. The study group comprised of females with an age range of 25-37 year who had duration of unexplained infertility for more than two years. They were grouped as; underweight (<18 kg/m2), normal weight (18-22.9 kg/m2), overweight 23-24.99 kg/m2 and obese (>25 kg/m2). Kisspeptin and Leptin levels were measured by enzyme linked immune sorbent assay before down regulation of ovaries and initiation of treatment protocol of ART. Failure of procedure was detected by beta human chorionic gonadotropin <25mIU/ml (non-pregnant) whereas females with levels >25mIU/ml and cardiac activity on trans-vaginal scan were declared pregnant.Results:Highest Kisspeptin and Leptin levels were seen in normal weight group (374.80 ± 185.08ng/L; 12.78 ± 6.8 pg/ml) respectively, yet the highest number of clinical pregnancy was observed in overweight group (42%).A strong correlation of Kisspeptin with Leptin (r=0.794, p=0.001) was observed in the overweight females.Conclusion:Leptin-Kisspeptin-fertility link is expressed by maximum number of clinical pregnancies in the female group that showed strongest relationship between serum Leptin and Kisspeptin levels, irrespective of their BMI.

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Leptin in bipolar disorder: A systematic review and meta-analysis

Cited by 34 publications

References 41 publications

Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients

Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients

Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques

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