2020
DOI: 10.1186/s12944-020-01203-z
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Abstract: Antipsychotic-induced weight gain is the most prevalent somatic adverse event occurring in patients treated by antipsychotics, especially atypical antipsychotics. It is of particular interest because of its repercussion on cardiovascular morbidity and mortality especially now that the use of second-generation antipsychotics has been extended to other mental health illnesses such as bipolar disorders and major depressive disorder. The mechanism underlying antipsychotics-induced weight gain is still poorly under… Show more

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Cited by 21 publications
(15 citation statements)
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References 99 publications
(257 reference statements)
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“…The leptin level in cerebrospinal fluid has been positively correlated with plasma leptin level and BMI (48). Another study found that leptin levels in schizophrenic patients treated with antipsychotics were higher than those in healthy controls, which was associated with weight gain caused by antipsychotics (49,50). In addition, studies on patients without medication have shown that low leptin levels are associated with schizophrenia, and antipsychotics will increase leptin levels.…”
Section: Discussionmentioning
confidence: 99%
“…The leptin level in cerebrospinal fluid has been positively correlated with plasma leptin level and BMI (48). Another study found that leptin levels in schizophrenic patients treated with antipsychotics were higher than those in healthy controls, which was associated with weight gain caused by antipsychotics (49,50). In addition, studies on patients without medication have shown that low leptin levels are associated with schizophrenia, and antipsychotics will increase leptin levels.…”
Section: Discussionmentioning
confidence: 99%
“…In general, confounders such as time of blood sampling, age, Body Mass Index (BMI), gender-associated metabolic disturbances, medication history and clinical type and features of depressive disorders, might impact peripheral leptin levels, and thereby justify inconsistent results obtained [ 101 , 104 , 107 , 114 , 115 ].…”
Section: Adipokinesmentioning
confidence: 99%
“…Increased levels of leptin on the administration of antipsychotics such as Olanzapine, clozapine, and Quatipine due to the high affinity of the drug against Muscarinic M3 and Histamin H1 receptors that contribute to increased food intake and weight gain. In typical antipsychotics such as haloperidol and chlorpromazine can increase levels of leptin through inhibition of D2 receptors in the tuberoinfundibular, thereby causing metabolic and weight-gain effects (4). According to research conducted Sentissi, increased levels of leptin compared with baseline occurred several hours after administration of the first treatment of atypical antipsychotic drugs, and increased between week 6 and 10, and remained stable up to several months (27).…”
Section: Et Al C Tested By Unpaired T-testmentioning
confidence: 99%
“…Atypical antipsychotics exhibit an action on other receptors in addition to dopamine D2, including dopamine receptors D1, D4, serotonin receptors (5HT1a, 5-HT1d, 5-HT2c, 5-HT6, 5HT7), M3 muscarinic receptors, histamine H1 receptors and adrenergic receptors (alpha 1 and Alpha 2). Additionally, atypical antipsychotics such as clozapine is known to work as an antagonistic effect of NMDA receptor hypofunctions at the center of conduct (4,5).…”
Section: Introductionmentioning
confidence: 99%