Leptin expression in HIV-infected patients during antiretroviral therapy

Tilişcan, Cătălin; Aramă, Victoria; Mihăilescu, Raluca; Munteanu, Daniéla; Streinu-Cercel, Adrian; Ion, Daniela Adriana; Rădulescu, Mihaela; Popescu, Cristina; Lobodan, Alina; Negru, Anca Ruxandra; Aramă, Ștefan Sorin

doi:10.11599/germs.2015.1076

Cited by 16 publications

(10 citation statements)

References 19 publications

(10 reference statements)

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“…Although variations in CLOCK gene have been associated with plasma ghrelin [72], associations between ghrelin gene variations and sleep parameters have not been reported. While leptin plasma levels do not appear to be associated with immunologic or virologic parameters in HIV-infected adults [73], plasma levels of ghrelin appear elevated in HIV-infected adults independent of BMI [74]. In the current study, one GHRL SNP was associated with better sleep (i.e., each additional copy of the rs26802 G allele with less WASO in unadjusted, and longer TST in unadjusted and adjusted models).…”

Section: J O U R N a L P R E -P R O O Fcontrasting

confidence: 58%

Sleep disruption and duration are associated with variants in genes involved in energy homeostasis in adults with HIV/AIDS

et al. 2021

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Objective: To determine whether selected genes and plasma markers involved in energy homeostasis are associated with sleep disruption or duration in adults with HIV/AIDS. Methods: A sample of 289 adults with HIV/AIDS wore a wrist actigraph for 72 hours to estimate total sleep time (TST) and wake after sleep onset (WASO). Twenty-three single nucleotide polymorphisms (SNP) spanning 5 energy homeostasis genes (adiponectin [ADIPOQ], ghrelin [GHRL], leptin [LEP], peroxisome proliferator-activated receptor-alpha [PPARA], and -gamma [PPARG]) were genotyped using a custom array. Plasma markers of energy homeostasis (adiponectin, ghrelin, leptin) were measured by commercial multiplex assay.Results: After adjusting for demographic and clinical characteristics (race/ethnicity, gender, CD4 cell count, waist circumference, medications), both WASO and TST were associated with SNPs in ADIPOQ (rs182052), LEP (rs10244329, rs3828942), PPARA (rs135551, rs4253655), and PPARG (rs709151). Additional SNPs in ADIPOQ were associated with WASO (rs1501299, rs3821799, rs6773957) and TST (rs2241766). TST was also associated with SNPs in GHRL (rs26802), LEP (rs11760956), PPARA (rs135547, rs8138102, rs4253776), and PPARG (rs12490265, rs796313).Many covariate-adjusted associations involved a significant interaction with markers of HIV (viral load, years since diagnosis). Among plasma markers, higher adiponectin was associated with less WASO, higher ghrelin and glucose levels with shorter TST, and higher leptin with longer TST.Conclusions: Replication of SNPs in all five genes and three plasma markers of energy homeostasis were associated with objective sleep measures. HIV disease influenced many of the associations. Findings strengthen evidence for associations between energy homeostasis genetics and poor sleep, and provide direction for pharmacological intervention research.

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Section: J O U R N a L P R E -P R O O Fcontrasting

confidence: 58%

Sleep disruption and duration are associated with variants in genes involved in energy homeostasis in adults with HIV/AIDS

et al. 2021

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“…After antiretroviral therapy, leptin level is lower at the poor immune response human immunodeficiency virus (HIV) patients as indicated by CD4 than those with better immune response. It might be justified that leptin may be involved in the link between the energy and nutritional status to the T helper immune response 20) . In a study of patients with TB, the production of C-reactive protein and TNF-α was inversely related to plasma leptin concentrations.…”

Section: Discussionmentioning

confidence: 99%

Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children

et al. 2017

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PurposeTuberculosis (TB) remains a problem in the community. TB patients usually experience malnutrition, which is characterized by both decreased body weight (BW) and body fat percentage (BFP). Leptin, an important regulator of BW, also plays an important role in cellular immunity, which is integral to defense against Mycobacterium tuberculosis infection. We analyzed the effect of an anti-TB treatment regimen on the leptin level, BW, and BFP of children with TB.MethodsThe design of this study was a group interrupted time series. The subjects were children with probable TB according to clinical criteria based on an Indonesian scoring system adopted from the Consensus of Expert Panel. BW; BFP; energy intake; fat and protein intake; and leptin levels before, 2 months after (intensive phase), and 6 months after (continuation phase) anti-TB treatment, were measured. About 40 children, aged 5–14 years, participated in this study.ResultsThe BW, BFP and leptin level increased from before treatment to after completion of the intensive phase and still showed an increased during the continuation phase: BW 18.65 kg, 19.75 kg, and 20.85 kg; BFP 18.3%, 19.5%, and 20.2%; and leptin level 1.9 mg/dL, 3.07 mg/dL, and 3.4 mg/dL, respectively (P<0.01).ConclusionLeptin level, BW, and BFP increased throughout the course of anti-TB treatment, compared with pretreatment values. Further research is needed to compare the results with data for healthy children.

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“…Indeed, long-term use of ART has been associated with lipodystrophic syndrome ( Finkelstein et al, 2015 ). Decreased levels of leptin have previously been observed in HIV-1-lipodystrophic patients ( Tiliscan et al, 2015 ; Tsoukas et al, 2015 ). This decrease inversely correlates with the occurrence of hyperlipidemia ( Nagy et al, 2003 ).…”

Section: Discussionmentioning

confidence: 76%

Evaluation of Oral Antiretroviral Drugs in Mice With Metabolic and Neurologic Complications

Tsai

Lai

et al. 2018

Front. Pharmacol.

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Antiretroviral (ART) drugs has previously been associated with lipodystrophic syndrome, metabolic consequences, and neuropsychiatric complications. ART drugs include three main classes of protease inhibitors (PIs), nucleoside analog reverse transcriptase inhibitors (NRTIs), and non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our previous work demonstrated that a high risk of hyperlipidemia was observed in HIV-1-infected patients who received ART drugs in Taiwan. Patients receiving ART drugs containing either Abacavir/Lamivudine (Aba/Lam; NRTI/NRTI), Lamivudine/Zidovudine (Lam/Zido; NRTI/NRTI), or Lopinavir/Ritonavir (Lop/Rit; PI) have the highest risk of hyperlipidemia. The aim of this study was to investigate the effects of Aba/Lam (NRTI/NRTI), Lam/Zido (NRTI/NRTI), and Lop/Rit (PI) on metabolic and neurologic functions in mice. Groups of C57BL/6 mice were administered Aba/Lam, Lam/Zido, or Lop/Rit, orally, once daily for a period of 4 weeks. The mice were then extensively tested for metabolic and neurologic parameters. In addition, the effect of Aba/Lam, Lam/Zido, and Lop/Rit on lipid metabolism was assessed in HepG2 hepatocytes and during the 3T3-L1 preadipocyte differentiation. Administration with Aba/Lam caused cognitive and motor impairments in mice, as well as their metabolic imbalances, including alterations in leptin serum levels. Administration with Lop/Rit also caused cognitive and motor impairments in mice, as well as their metabolic imbalances, including alterations in serum levels of total cholesterol, and HDL-c. Treatment of mice with Aba/Lam and Lop/Rit enhanced the lipid accumulation in the liver, and the decrease in AMP-activated protein kinase (AMPK) phosphorylation and/or its downstream target acetyl-CoA carboxylase (ACC) protein expression. In HepG2 hepatocytes, Aba/Lam, Lam/Zido, and Lop/Rit also enhanced the lipid accumulation and decreased phosphorylated AMPK and ACC proteins. In 3T3-L1 pre-adipocyte differentiation, Aba/Lam and Lop/Rit reduced adipogenesis by decreasing expression of transcription factor CEBPb, implicating the lipodystrophic syndrome. Our results demonstrate that daily oral administration of Aba/Lam and Lop/Rit may produce cognitive, motor, and metabolic impairments in mice, regardless of HIV-1 infection.

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Leptin expression in HIV-infected patients during antiretroviral therapy

Cited by 16 publications

References 19 publications

Sleep disruption and duration are associated with variants in genes involved in energy homeostasis in adults with HIV/AIDS

Sleep disruption and duration are associated with variants in genes involved in energy homeostasis in adults with HIV/AIDS

Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children

Evaluation of Oral Antiretroviral Drugs in Mice With Metabolic and Neurologic Complications

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