Leptin drives fat distribution during diet-induced obesity in mice

Guzmán‐Ruiz, Rocío; Stucchi, Paula; Ramos, M. Teresa; Sevillano, Julio; Somoza, Beatriz; Fernández-Alfonso, Marisol; Ruiz‐Gayo, Mariano

doi:10.1016/j.endonu.2012.04.001

Cited by 13 publications

(13 citation statements)

References 14 publications

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“…After HFD interventions, plasma leptin usually correlates positively with adiposity [17,51]. Here, we observed that the group exposed to ad libitum HFD + EtOH displayed higher plasma leptin levels than the other experimental groups, indicating that bingeing on EtOH also potentiated the effect of HFD in terms of leptin production, coherently with the enlargement of fat pads detected in this group.…”

Section: Discussionsupporting

confidence: 69%

Differential Impact of Ad Libitum or Intermittent High-Fat Diets on Bingeing Ethanol-Mediated Behaviors

et al. 2019

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Background: Dietary factors have significant effects on the brain, modulating mood, anxiety, motivation and cognition. To date, no attention has been paid to the consequences that the combination of ethanol (EtOH) and a high-fat diet (HFD) have on learning and mood disorders during adolescence. The aim of the present work was to evaluate the biochemical and behavioral consequences of ethanol binge drinking and an HFD consumption in adolescent mice. Methods: Animals received either a standard diet or an HFD (ad libitum vs. binge pattern) in combination with ethanol binge drinking and were evaluated in anxiety and memory. The metabolic profile and gene expression of leptin receptors and clock genes were also evaluated. Results: Excessive white adipose tissue and an increase in plasma insulin and leptin levels were mainly observed in ad libitum HFD + EtOH mice. An upregulation of the Lepr gene expression in the prefrontal cortex and the hippocampus was also observed in ad libitum HFD groups. EtOH-induced impairment on spatial memory retrieval was absent in mice exposed to an HFD, although the aversive memory deficits persisted. Mice bingeing on an HFD only showed an anxiolytic profile, without other alterations. We also observed a mismatch between Clock and Bmal1 expression in ad libitum HFD animals, which were mostly independent of EtOH bingeing. Conclusions: Our results confirm the bidirectional influence that occurs between the composition and intake pattern of a HFD and ethanol consumption during adolescence, even when the metabolic, behavioral and chronobiological effects of this interaction are dissociated.

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Section: Discussionsupporting

confidence: 69%

Differential Impact of Ad Libitum or Intermittent High-Fat Diets on Bingeing Ethanol-Mediated Behaviors

et al. 2019

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“…Changes in plasma adipokine and cytokine levels have been reported in obesity [33]; however, there are a limited number of reports on how these plasma analytes are altered during weight gain and the influence of sexual dimorphism on them. Hyperleptinemia was evident in both HFD females and males, which is consistent with previous studies [33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Sexual Dimorphism in Changes That Occur in Tissues, Organs and Plasma during the Early Stages of Obesity Development

Dhanraj

Heerden

Pepper

et al. 2021

Biology

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Despite obesity being a major health concern, information on the early clinical changes that occur in plasma and tissues during obesity development and the influence of sexual dimorphism is lacking. This study investigated changes in tissue and organ histology, macrophage infiltration, plasma hormones, lipid, and chemokine and cytokine levels in mice fed on a high fat diet for 11-weeks. An increase in adiposity, accompanied by adipocyte hypertrophy and macrophage infiltration, was observed to be significantly greater in males than females. Important changes in cell morphology and histology were noted in the lungs, liver, kidney, spleen, and heart, which may indicate early signs for developing obesity associated comorbidities. Leptin, but not adiponectin, was significantly altered during weight gain. Additionally, leptin, but not adiposity, correlated with insulin levels. Interestingly, GM-CSF, TNFα, and IL-12 (p70) were not produced in the early stages of obesity development. Meanwhile, the production of MCP-1, IP-10, RANTES, IL-10, IL-6, KC, and IL-9 were greatly influenced by sexual dimorphism. Importantly, IL-6/IL-10 axis of anti-inflammatory cytokine regulation was observed only in females and may account for their significantly lower weight gain compared to males. This study provides new knowledge on how sexual dimorphism may influence the development of obesity and associated comorbidities.

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“…One study, through dissociating insulin from leptin action by VAT removal, suggested that the failure of leptin action is in fact the major pathophysiological mechanism for HS, while another indicated that the anti‐steatotic effects of leptin in the liver are maintained through food restriction . A different study showed that the onset of leptin signalling disruption within the liver coincided with the commencement of HS and suggested that the liver accumulates triglycerides when adipose tissue fails to trap them . It also indicated that leptin resistance does not simultaneously develop in all tissues .…”

Section: Discussionmentioning

confidence: 99%

“…A different study showed that the onset of leptin signalling disruption within the liver coincided with the commencement of HS and suggested that the liver accumulates triglycerides when adipose tissue fails to trap them . It also indicated that leptin resistance does not simultaneously develop in all tissues . The lack of hepatic leptin signalling obtained by a Cre‐lox approach in ob/ob mice was associated with increased hepatic accumulation of large, triglyceride‐rich lipoprotein particles .…”

Section: Discussionmentioning

confidence: 99%

Serum leptin and leptin resistance correlations with NAFLD in patients with type 2 diabetes

Cernea

Roiban

Both³

et al. 2018

Diabetes Metabolism Res

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Leptin drives fat distribution during diet-induced obesity in mice

Cited by 13 publications

References 14 publications

Differential Impact of Ad Libitum or Intermittent High-Fat Diets on Bingeing Ethanol-Mediated Behaviors

Differential Impact of Ad Libitum or Intermittent High-Fat Diets on Bingeing Ethanol-Mediated Behaviors

Sexual Dimorphism in Changes That Occur in Tissues, Organs and Plasma during the Early Stages of Obesity Development

Serum leptin and leptin resistance correlations with NAFLD in patients with type 2 diabetes

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