Serum leptin and leptin resistance correlations with NAFLD in patients with type 2 diabetes

Cernea, Simona; Roiban, Andrada Larisa; Both, Emőke; Huţanu, Adina

doi:10.1002/dmrr.3050

Cited by 46 publications

(43 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, C‐peptide was found to be involved in the regulation of leptin secretion, which is intimately involved in energy homeostasis processes, through PI3K or PKB pathways . Leptin has been suggested to play a role in NAFLD and especially in type 2 diabetic patients; a study indicated that liver steatosis correlated positively with serum leptin …”

Section: Discussionmentioning

confidence: 99%

C‐peptide is associated with NAFLD inflammatory and fibrotic progression in type 2 diabetes

Wang

Zhang

et al. 2019

Diabetes Metabolism Res

View full text Add to dashboard Cite

Background: A higher prevalence of nonalcoholic steatohepatitis (NASH) and advanced stages of fibrosis was observed in type 2 diabetes. We aim to investigate whether C-peptide is associated with nonalcoholic fatty liver disease (NAFLD) progression in type 2 diabetic adults. Methods:A total of 4937 diabetic participants were enrolled from China in 2018.Liver steatosis was detected by ultrasound. Subjects with NAFLD were categorized into simple NAFLD and probable NASH by the concurrent presence of metabolic syndrome. NAFLD fibrosis score was used to identify patients with probable advanced fibrosis.Results: Individuals with a longer history of type 2 diabetes had a lower C-peptide level and a lower prevalence of probable NASH but a higher prevalence of advanced fibrosis. C-peptide was positively associated with simple NAFLD and probable NASH, with odds ratios (ORs) of 4.55 [95% confidence interval (CI) 3.16, 6.55] and 5.28 (95% CI 3.94, 7.09), respectively, comparing quartile 4 with quartile 1 (both p for trend <0.001). However, C-peptide quartiles were negatively associated with the probable presence of advanced fibrosis (Q4 vs. Q1, OR 0.59, 95% CI 0.36, 0.97, p for trend <0.05). A 1-SD increment of ln(C-peptide) was also significantly associated with inflammatory and fibrotic progression (OR 1.34, 95% CI 1.27, 1.41; OR 0.88, 95% CI 0.79, 0.98, respectively).Conclusions: Significant but opposite associations between C-peptide and inflammatory and fibrotic progression of NAFLD were observed. Understanding islet hormone changes during type 2 diabetes and differentiating the stage of NAFLD may help to personalize treatment strategies for NAFLD patients with type 2 diabetes. KEYWORDS

show abstract

Section: Discussionmentioning

confidence: 99%

C‐peptide is associated with NAFLD inflammatory and fibrotic progression in type 2 diabetes

Wang

Zhang

et al. 2019

Diabetes Metabolism Res

View full text Add to dashboard Cite

show abstract

“…Details regarding study participants, materials, and methods have been published previously. 9 The study was approved by the Ethics Committee of the University of Medicine and Pharmacy of Tîrgu Mureș, and all participants signed an informed consent before being enrolled.…”

Section: Study Populationmentioning

confidence: 99%

Malnutrition and Metabolic Changes in Patients with Type 2 Diabetes

Roiban

Both²

2018

Journal of Interdisciplinary Medicine

Self Cite

View full text Add to dashboard Cite

Background/Aim: In patients with type 2 diabetes (T2D), malnutrition has been recognized as a serious health problem mainly in hospitalized conditions, but there is little data regarding malnutrition outside hospital settings. The aim of this study was to evaluate the risk of malnutrition and associated metabolic changes in ambulatory patients with T2D. Material and methods: This analysis used data collected from 161 patients with T2D enrolled in a larger crosssectional study. Several anthropometric and metabolic parameters were obtained. Nutritional status was evaluated using the Controlling Nutritional Status (CONUT) score. Correlations between nutritional status and metabolic and anthropometric parameters of interest were examined. Results: Of all T2D patients, 29.8% had mild malnutrition (CONUT score 2-4). These patients presented lower triglyceride (124.8 ± 42.3 mg/dL vs. 165.7 ± 84.3 mg/dL, p <0.01) and LDL cholesterol concentrations (62.7 ± 20.0 mg/dL vs. 104.9 ± 30.6 mg/dL, p <0.0001), higher leptin levels (10.2 [1.6-44.9] ng/mL vs. 7.3 [0.9-49.8] ng/mL, p <0.05) and free leptin index (0.65 [0.04-2.88] vs. 0.36 [0.01-3.98], p <0.05) compared with patients with normal nutritional status. They also had higher total body adiposity. In patients with obesity, triglycerides levels were lower in those with mild malnutrition vs. those without malnutrition (mean difference: 27.26 mg/ dL, p <0.05). Serum C peptide/leptin ratio was higher in T2D patients with normal nutritional status without obesity, the differences being significant vs. the two groups with obesity (with or without malnutrition, 0.71 ± 0.53, 0.42 ± 0.33, and 0.49 ± 0.68, respectively). HOMA-IR was lower in patients with normal nutritional status without obesity vs. those with obesity (mean difference: -0.7126, p <0.05), while in patients with mild malnutrition, HOMA-IR values were higher, but no differences were noted between the groups with or without obesity. Conclusion: In patients with T2D, malnutrition associated with lower triglycerides concentrations, even in the presence of obesity. Malnutrition and/or obesity associated with higher HOMA-IR, serum leptin levels and lower C peptide/leptin ratio.

show abstract

“…One of these adipokines is leptin, a polypeptide hormone, secreted in concentrations proportional to body fat mass, that plays an important role in a number of physiological functions like energy homeostasis, immunity and reproduction, with possible implication in other conditions (such as hepatic steatosis, depression etc.) (4)(5)(6). Leptin is required to maintain normal body weight, as it lowers food intake and increases energy expenditure (4).…”

Section: Introductionmentioning

confidence: 99%

The association of anthropometric parameters with markers of insulin and leptin secretion and resistance in type 2 diabetes mellitus

Both¹,

Fodor

2020

Revista Romana De Medicina De Laborator

Self Cite

View full text Add to dashboard Cite

Aim: We evaluated the association between anthropometric parameters and markers of insulin and leptin secretion/resistance in patients with type 2 diabetes mellitus (T2DM).Material and methods: This post-hoc data analysis from a cross-sectional study included 176 T2DM patients. Laboratory tests (serum leptin, soluble form of leptin receptor (sObR), C peptide, glycemic and lipid parameters) and anthropometric parameters were obtained, adiposity indexes (including body adiposity index (BAI), visceral adiposity index (VAI)), indicators of insulin resistance, β-cell function, and leptin resistance (Free Leptin Index, FLI) were calculated.Results: The body mass index (BMI), diabetes duration, VAI and leptin correlated independently with HOMA-IR, while BMI, diabetes duration and HbA1c with HOMA-B. The total body fat mass (TBFM), C peptide, diabetes duration, BMI and BAI correlated with leptin concentrations, while the first three with FLI. VAI was an indicator of insulin resistance (β=0.166, p=0.003), while BAI of leptin secretion (β=0.260, p=0.010). TBFM strongly associated with leptin resistance and secretion (β=0.037, r=0.688, p<0.0001, and β=0.521, r=0.667, p<0.0001), and BMI correlated weakly with insulin secretion and resistance. While insulin and leptin secretion increased progressively with BMI, leptin and insulin resistance became significant only in case of obesity. The sObR was significantly associated with C peptide concentrations (β=-0.032; p=0.044), but not with HOMA-B or -IR. A strong positive correlation between the C peptide/leptin ratio and non-fat mass /TBFM ratio was noted (r=0.62 [0.52, 0.71], p<0.0001).Conclusions: Parameters of peripheral adiposity correlated better with markers of leptin system, and those of visceral adiposity with markers of insulin secretion/resistance. The sObR correlated independently and negatively with C peptide.

show abstract

Serum leptin and leptin resistance correlations with NAFLD in patients with type 2 diabetes

Abstract: In patients with T2D, HS correlated positively with serum leptin and leptin resistance, and negatively with sObR, along with variables of adiposity and metabolic control, but neither of them made a significant contribution to HF.

Cited by 46 publications

References 48 publications

C‐peptide is associated with NAFLD inflammatory and fibrotic progression in type 2 diabetes

C‐peptide is associated with NAFLD inflammatory and fibrotic progression in type 2 diabetes

Malnutrition and Metabolic Changes in Patients with Type 2 Diabetes

The association of anthropometric parameters with markers of insulin and leptin secretion and resistance in type 2 diabetes mellitus

Contact Info

Product

Resources

About