Leptin as a metabolic link to multiple sclerosis

Matarese, Giuseppe; Carrieri, P; Montella, Silvia; Rosa, Veronica De; Cava, Antonio La

doi:10.1038/nrneurol.2010.89

Cited by 85 publications

(93 citation statements)

References 45 publications

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“…Previous studies have shown that MS is associated with increased levels of leptin in serum and cerebrospinal fluid (CSF) specimen drawn from naive-to-treatment relapsing-remitting MS (RRMS) patients in the acute phase of their disease [16,17,18]. Higher serum levels of leptin were also found in patients with MS in remission, as compared with healthy controls [19].…”

Section: Introductionmentioning

confidence: 88%

Severe Disability in Patients with Relapsing-Remitting Multiple Sclerosis Is Associated with Profound Changes in the Regulation of Leptin Secretion

Rotondi

Batocchi

Coperchini

et al. 2013

Neuroimmunomodulation

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Objectives: Experimental evidences indicate that leptin is involved in the neuroinflammatory process sustaining multiple sclerosis (MS). However, the relationship between leptin and body fat, as assessed by body mass index (BMI), in MS was not previously evaluated. It was the aim of this study to compare serum leptin levels between patients with MS and healthy controls and to evaluate the possible relationship between circulating leptin levels and disease severity. Patients and Methods: Eighty-four MS patients and 57 sex-matched healthy volunteers were enrolled. Serum leptin levels were measured in all patients and controls. MS patients were stratified in 3 groups according to their degree of disability as assessed by the Expanded Disability Status Scale (EDSS). Patients were classified as having low (33 patients with an EDSS score <1.5), intermediate (28 patients with an EDSS score from 2 to 3) and high disability (23 patients with an EDSS score ≥3.5). Results: No significant differences in serum leptin levels and BMI were observed between patients and controls. In patients with MS, serum leptin levels were significantly correlated with BMI in those patients with low (R² = 0.363; p < 0.001) and intermediate disability (R² = 0.408; p < 0.001), but not in patients with a higher disability score (R² = 0.064; p = 0.256). Conclusion: BMI, the major determinant of leptin level in physiological conditions, has a minor role in determining the serum levels of leptin in MS patients with a high EDSS score. Future longitudinal studies will be required in order to provide further insights into the regulation of leptin secretion in patients with MS.

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Section: Introductionmentioning

confidence: 88%

Severe Disability in Patients with Relapsing-Remitting Multiple Sclerosis Is Associated with Profound Changes in the Regulation of Leptin Secretion

Rotondi

Batocchi

Coperchini

et al. 2013

Neuroimmunomodulation

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“…In conclusion, the results reported in this study may facilitate a better understanding of the role of ECs and CB 1 receptors in leptin-mediated effects on food intake and energy storage/expenditure as well as other physiopathological functions of this hormone, such as its role in neuroinflammation (38).…”

Section: -Agmentioning

confidence: 99%

Negative Regulation of Leptin-induced Reactive Oxygen Species (ROS) Formation by Cannabinoid CB1 Receptor Activation in Hypothalamic Neurons

Palomba

Silvestri

Imperatore

et al. 2015

Journal of Biological Chemistry

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Background:In hypothalamic neurons, leptin induces ROS production via PPAR-␥ inhibition. Results: CB1 agonism prevents leptin-induced ROS accumulation by reversing PPAR-␥ and catalase inhibition. Inhibition of endocannabinoid inactivation also counteracts leptin effects. Conclusion: CB 1 inhibits effects of leptin that underlie part of its anorexic actions. Significance: During conditions of increased endocannabinoid tone CB 1 might reduce leptin activity in the hypothalamus.

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“…Normal leptin levels crucially maintain and regulate the body's immune function. Emerging evidence indicates that leptin acts as a proinflammatory cytokine in immune responses such as systemic lupus erythematosus (SLE) [3][4][5][6], RA [7][8][9][10], multiple sclerosis (MS) [11][12][13] and psoriasis [14][15][16]. Leptin could be a member of the cytokine network managing the inflammatory immune response and host defence mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Emerging role of leptin in rheumatoid arthritis

Tian

Liang

Wang

et al. 2014

Clinical and Experimental Immunology

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SummaryNumerous studies have suggested the importance of leptin against autoimmune diseases such as systemic lupus erythematosus (SLE), multiple sclerosis (MS) and psoriasis. To summarize our current understanding of the role of leptin in inflammatory responses and rheumatoid arthritis (RA), a systematic review was conducted to assess the discrepancy of leptin in RA and its effect on immunity according to different studies. Recently, emerging data have indicated that leptin is involved in the pathological function of RA, which is common in autoimmune disorders. This review discusses the possible consequences of leptin levels in RA. Blocking the key signal pathways of leptin and inhibiting the leptin activity-like leptin antagonist may be a promising way for potential therapeutic treatment of RA at risk of detrimental effects. However, leptin was increased in patients with RA and may also regulate joint damage. Thus, more understanding of the mechanism of leptin in RA would be advantageous in the future.

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Leptin as a metabolic link to multiple sclerosis

Cited by 85 publications

References 45 publications

Severe Disability in Patients with Relapsing-Remitting Multiple Sclerosis Is Associated with Profound Changes in the Regulation of Leptin Secretion

Severe Disability in Patients with Relapsing-Remitting Multiple Sclerosis Is Associated with Profound Changes in the Regulation of Leptin Secretion

Negative Regulation of Leptin-induced Reactive Oxygen Species (ROS) Formation by Cannabinoid CB1 Receptor Activation in Hypothalamic Neurons

Emerging role of leptin in rheumatoid arthritis

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