Leptin and the GA genotype of rs2167270 of the <i>LEP</i> gene increase the risk of prediabetes

Aljanabi, Mukhallad; Alfaqih, Mahmoud A.; Khanfar, Mariam; Amarin, Zouhair; Elsalem, Lina; Saadeh, Rami; Al‐Μughales, Faheem

doi:10.3892/br.2021.1420

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…In a study on common variants in the leptin gene, researchers showed an association of the AA genotype of the rs7799039 variant with the development of obesity in the population of South India [ 136 ]. The A allele of rs2167270 significantly correlates with an elevated risk of prediabetes in Jordan and in the population of South India [ 137 , 138 , 139 ]. Rs6966536 (allele G) of the LEP gene has been implicated in the development of obesity in a South African population [ 140 ].…”

Section: Resultsmentioning

confidence: 99%

Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review

Bairqdar

Ivanoshchuk

Shakhtshneider

2023

JPM

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The high prevalence of obesity and of its associated diseases is a major problem worldwide. Genetic predisposition and the influence of environmental factors contribute to the development of obesity. Changes in the structure and functional activity of genes encoding adipocytokines are involved in the predisposition to weight gain and obesity. In this review, variants in genes associated with adipocyte function are examined, as are variants in genes associated with metabolic aberrations and the accompanying disorders in visceral obesity.

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Section: Resultsmentioning

confidence: 99%

Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review

Bairqdar

Ivanoshchuk

Shakhtshneider

2023

JPM

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“…Instead, the A allele and GG genotype of rs2167270 were more prevalent among atopic dermatitis patients (13). Aljanabi et al (19) also showed that both the A allele and GA genotype of rs2167270 of the leptin gene are highly associated with the prevalence of prediabetes (P < 0.05). The different genotypes of SNP rs2167270 are thought to be associated with higher or lower expression of the LEP gene (20).…”

Section: Discussionmentioning

confidence: 99%

The Association of Leptin Gene Polymorphisms with Crohn's Disease in a Chinese Pediatric Population

Sun

Shi

et al. 2023

Iran J Pediatr

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Background: Leptin is thought to play an important role in Crohn's disease (CD) pathogenesis and progression. Independent studies have revealed a strong upregulation of leptin expression in the mesenteric fat of CD patients. Objectives: This study assessed the relationship between leptin gene polymorphisms and CD susceptibility in a Chinese pediatric population. Methods: A total of 86 patients with CD and 142 healthy controls were recruited for this case-control study. The genotypes of 4 single-nucleotide polymorphisms (SNPs; rs2071045, rs41457646, rs11761556, and rs2167270) in the leptin gene were determined by multiplex polymerase chain reaction (PCR) combined with next-generation sequencing. Results: We found that leptin rs2167270 had a significantly different distribution of alleles and genotypes between CD patients and healthy controls (G is a risk allele: 83.7% of cases vs 72.5% of controls; odds ratio [OR] 1.947; 95% CI, 1.203-3.151; P = 0.006; GG is a risk genotype: 72.1% of cases vs 53.5% of controls; P = 0.021). Patients with the CC genotype (rs2071045) had a significantly increased risk of early onset of CD (58.3% in A1a vs 31.1% in A1b; P = 0.003). Similarly, patients carrying the G allele (100% in A1a vs 84.1% in A1b; P = 0.015) and GG genotype (100% in A1a vs 71.0% in A1b; P = 0.048) of rs41457646, A allele (93.3% in A1a vs 71.8% in A1b; P = 0.013) and AA genotype (93.3% in A1a vs 47.9% in A1b; P = 0.003) in rs11761556 had a higher risk of early onset of CD. However, there was no significant difference in any of these 4 SNPs between patients with and without perianal lesions, as well as in low and normal body mass index (BMI) patients. Conclusions: The leptin rs2167270 polymorphism is associated with the susceptibility to CD in a Chinese pediatric population. Leptin rs2071045, rs41457646, and rs11761556 might lead to the early onset of pediatric CD.

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“…It was also found that patients with poor glycemic control have lower serum leptin levels. Interestingly, our group showed that Jordanian patients who have prediabetes, a state characterized by elevated levels of serum leptin, are more likely to carry the GA genotype of rs2167270 [ 21 ]. Taken together, it could be hypothesized that in Jordan, the GA genotype of rs2167270 is linked with metabolic conditions associated with elevated levels of serum leptin.…”

Section: Discussionmentioning

confidence: 99%

“…Leptin is a hormone-like adipokine secreted by adipose tissue cells [ 21 , 22 ]. Inactivating mutations in the gene that codes for the leptin hormone ( LEP ) are linked with obesity in humans [ 23 ] and in rodent models [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Leptin and the rs2167270 Polymorphism Are Associated with Glycemic Control in Type Two Diabetes Mellitus Patients on Metformin Therapy

et al. 2023

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Background and Objectives: Type two diabetes mellitus (T2DM) is a chronic disease with debilitating complications and high mortality. Evidence indicates that good glycemic control delays disease progression and is hence a target of disease management protocols. Nonetheless, some patients cannot maintain glycemic control. This study aimed to investigate the association between serum leptin levels and several SNPs of the LEP gene with the lack of glycemic control in T2DM patients on metformin therapy. Materials and Methods: In a hospital-based case-control study, 170 patients with poor glycemic control and 170 patients with good glycemic control were recruited. Serum leptin was measured. Patients were genotyped for three SNPs in the LEP gene (rs7799039, rs2167270, and rs791620). Results: Serum leptin was significantly lower in T2DM patients with poor glycemic control (p < 0.05). In multivariate analysis, serum leptin levels significantly lowered the risk of having poor glycemic control (OR = 0.985; CI: 0.976–0.994; p = 0.002); moreover, the GA genotype of rs2167270 was protective against poor glycemic control compared to the GG genotype (OR = 0.417; CI: 0.245–0.712; p = 0.001). Conclusions: Higher serum leptin and the GA genotype of the rs2167270 SNP of the LEP gene were associated with good glycemic control in T2DM patients on metformin therapy. Further studies with a larger sample size from multiple institutions are required to validate the findings.

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Leptin and the GA genotype of rs2167270 of the LEP gene increase the risk of prediabetes

Cited by 5 publications

References 33 publications

Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review

Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review

The Association of Leptin Gene Polymorphisms with Crohn's Disease in a Chinese Pediatric Population

Leptin and the rs2167270 Polymorphism Are Associated with Glycemic Control in Type Two Diabetes Mellitus Patients on Metformin Therapy

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