Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review

Bairqdar, Ahmad; Ivanoshchuk, D.; Shakhtshneider, E.

doi:10.3390/jpm13030460

Cited by 3 publications

(1 citation statement)

References 187 publications

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“…Gene selection for target sequencing was based on a review of the literature related to clinical features such as obesity and metabolic syndrome (central obesity, hyperglycemia, hypertriglyceridemia, Type 2 diabetes) and significant genetic variants associated with them [22] and included the genes (ADIPOQ, ADRB3, APLN, APLNR, FTO, GCG, GLP1R, GHRL, GIP, INS, LEP, NAMPT, PPY, PYY, RETN, and SCT). The target panel was designed using an available online tool (AmpliSeq, Illumina, San Diego, CA, USA) and included coding parts and adjacent splicing sites.…”

Section: Dna Extraction and Target Panel Designmentioning

confidence: 99%

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

Bairqdar,

Shakhtshneider,

Ivanoshchuk

et al. 2023

JPM

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The increase in the prevalence of overweight, obesity and associated diseases is a serious problem. The aim of the study was to identify rare variants in obesity-associated genes in young adults with abdominal obesity in our population and to analyze information about these variants in other populations. Targeted high-throughput sequencing of obesity-associated genes was performed (203 young adults with an abdominal obesity phenotype). In our study, all of the 203 young adults with abdominal obesity had some rare variant in the genes associated with obesity. The widest range of rare and common variants was presented in ADIPOQ, FTO, GLP1R, GHRL, and INS genes. The use of targeted sequencing and clinical criteria makes it possible to identify carriers of rare clinically significant variants in a wide range of obesity-associated genes and to investigate their influence on phenotypic manifestations of abdominal obesity.

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Section: Dna Extraction and Target Panel Designmentioning

confidence: 99%

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

Bairqdar,

Shakhtshneider,

Ivanoshchuk

et al. 2023

JPM

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Novel genomic variants related to Visceral Adiposity Index (VAI) and Body Adiposity Index (BAI) in Indian Sib-pairs

Walia,

Agarwal,

Lyngdoh

et al. 2023

Preprint

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Background: Obesity is among the leading public health threats globally. Over the last few years, Visceral Adiposity Index (VAI), and Body Adiposity Index (BAI), derived from anthropometric, and biochemical measures, have gained importance as a measure of obesity. However, unlike other common indices like body mass index, and waist circumference, the genetic predisposition of VAI, and BAI under-examined. Methods: 2265 sib-pairs from Indian Migration Study were used for examining the association of genetic variants from the Cardio-Metabochip array with VAI, and BAI. Mixed linear regression models were run, and all inferences were based on the within-sib component of the Fulker’s association models. Gene-environment/lifestyle interaction analyses were also undertaken. Results: rs6659428 at LOC400796|SEC16B (ꞵ=0.26, SE =0.05), and rs7611535 at DRD3|LOC645180 (ꞵ=0.18,SE =0.04) were associated with VAI at suggestive significance value of <8.21×10-6. For BAI, rs73300702 at JAZF1-AS1 (ꞵ=0.27,SE=0.06), was the top hit at p-value<8.21×10-6. rs6659428 showed marginal effect modification with location (ꞵ=0.26,SE=0.13,p-value=0.047), and rs73300702 with physical activity (ꞵ=-0.29,SE=0.14,p-value=0.034). Conclusion: We report three novel genetic loci associated with VAI, and BAI in Indians. These findings need to be confirmed with longitudinal or validation studies in other populations and related functional studies for understanding the biological mechanisms of obesity and related-cardiometabolic conditions.

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Novel Genomic Variants Related to Visceral Adiposity Index (VAI) and Body Adiposity Index (BAI) in Indian Sib-Pairs

Agarwal,

Lyngdoh,

Khadgawat

et al. 2023

Preprint

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Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review

Cited by 3 publications

References 187 publications

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

Novel genomic variants related to Visceral Adiposity Index (VAI) and Body Adiposity Index (BAI) in Indian Sib-pairs

Novel Genomic Variants Related to Visceral Adiposity Index (VAI) and Body Adiposity Index (BAI) in Indian Sib-Pairs

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