Leptin and Ghrelin Levels in Patients with Obstructive Sleep Apnea Syndrome

Çiftçi, Tansu Ulukavak; Köktürk, Oğuz; Bukan, Neslihan; Bi̇lgi̇han, Ayşe

doi:10.1159/000086254

Cited by 108 publications

(49 citation statements)

References 40 publications

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“…Elimination of OSAS by continuous positive airway pressure treatment decreased leptin levels. The insulin resistance was also obtained with leptin resistance in adults with OSAS [28,29]. There are relatively few OSAS studies in children due mainly to hardness of polysomnographic applications and insufficient equipment.…”

Section: Discussionmentioning

confidence: 99%

Leptin and Ghrelin Levels in Children before and after Adenoidectomy or Adenotonsillectomy

Karalök

Akdağ²,

Turhan³

et al. 2013

Horm Res Paediatr

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Background and Aim: Accelerated weight gain after (adeno)tonsillectomy has been reported in a number of studies. Whether (adeno)tonsillectomy is also a risk factor for development of overweight is unknown. We investigated serum leptin and plasma ghrelin levels before and 1 year after (adeno)tonsillectomy operation in children. Materials and Methods: We studied 31 patients and 29 age- and sex-matched healthy control children. Auxologic evaluation and biochemical investigations were performed before surgery and 1 year later. Results: One year after surgery, height SDS (p = 0.001) and weight SDS (p = 0.004) were significantly increased in both groups. No changes in BMI SDS (p = 0.105) were observed. Preoperative leptin levels were significantly higher in patients than controls (p < 0.001). IGF-1, IGFBP-3, HOMA-IR and ghrelin values were not significantly different between the groups. One year after surgery, IGF-1 (p = 0.001) and IGFBP-3 (p = 0.001) were significantly increased, while ghrelin (p < 0.001) was significantly decreased. Postoperative leptin levels of patients were also significantly higher than preoperative values (p = 0.036). Conclusion: Significantly higher leptin levels in patients compared to control both before and 1 year after an obstruction-relieving surgery suggested that higher levels might be due to leptin resistance in these patients. Based on our findings we recommend measurement of leptin levels longitudinally for at least 5 years after adenotonsillectomy.

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Section: Discussionmentioning

confidence: 99%

Leptin and Ghrelin Levels in Children before and after Adenoidectomy or Adenotonsillectomy

Karalök

Akdağ²,

Turhan³

et al. 2013

Horm Res Paediatr

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“…OSA is associated with altered levels of several adipokines including leptin [18, 45, 46] and adiponectin [47, 48]. Circulating leptin levels have been found to increase with increasing sympathetic activity [45].…”

Section: Discussionmentioning

confidence: 99%

Resistin Is Closely Related to Systemic Inflammation in Obstructive Sleep Apnea

et al. 2008

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Background: Obstructive sleep apnea (OSA) is closely related to systemic inflammation. Resistin is an adipocyte-derived cytokine (adipokine) that may link obesity with inflammation. Objective: We aimed to investigate whether incremental changes in OSA severity, from normal to severe, primarily affect the levels of resistin and other adipokines. Methods: Serum levels of resistin, interleukin-6 (IL-6) and leptin were examined in 31 men with OSA and 10 men without OSA, matched for age, body mass index (BMI) and several metabolic profiles. In 11 of the 31 men with OSA, these mediators were reexamined after 3 months of nasal continuous airway pressure (nCPAP) therapy. Results: Levels of resistin and IL-6 were simultaneously elevated in men with OSA compared with those in men without OSA (p < 0.05), while levels of leptin did not differ. The resistin and IL-6 levels tended to increase with increasing disease severity (p < 0.05), which was based on the apnea-hypopnea index (AHI). The average oxyhemoglobin saturation during sleep (p < 0.01) and IL-6 (p < 0.05) emerged as significant determinants of resistin, even after adjustments for age, BMI, leptin levels and metabolic risk factors. After nCPAP therapy, the elevated levels of resistin and IL-6 decreased, reaching almost baseline levels of controls. Before treatment, AHI correlated positively with the reduction rate in resistin (p < 0.05). Conclusion: In OSA patients, resistin production can be enhanced by hypoxic stress during sleep, possibly mediating systemic inflammatory processes. nCPAP therapy may play a beneficial role in the control of resistin production.

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“…The decrease in functional residual capacity associated with obesity diminishes oxygen stores thereby increasing the likelihood of hypoxemia during apneic events. Alterations in the mechanisms of the central regulation of respiratory control or in the tone of airways may also be implicated in the development of the syndrome [2, 7]. …”

Section: Introductionmentioning

confidence: 99%

Bariatric Surgery in the Treatment of Obstructive Sleep Apnea in Morbidly Obese Patients

Fritscher

Canani

Mottin³

et al. 2007

Respiration

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Background: Weight loss has been shown effective in the treatment of the obstructive sleep apnea-hypopnea syndrome. Regrettably, many obese patients are unable to achieve sustained and useful weight loss by dietary means. Recently, bariatric surgery has emerged as an alternative to treat obesity and many of its comorbidities, although its role for sleep apnea treatment is still not defined. Objectives: To evaluate the impact of bariatric surgery on obstructive sleep apnea in morbidly obese patients. Methods: In this cohort study, polysomnography, Epworth Sleepiness Scale questionnaire and clinical assessment were performed in 12 of 13 morbidly obese patients with moderate to severe obstructive sleep apnea treated with bariatric surgery through Roux-en-Y gastric bypass procedure after a minimum of 18 months post surgery. Results: The mean (±SD) loss of excess body weight was 70.5 ± 24%. The mean level obtained in the Epworth Scale was 4.8. There was a significant reduction in the apnea-hypopnea index, from a median of 46.5 (range: 33–140) to 16 (range: 0.9–87) events per hour (p < 0.05), an improvement in mean oxygen saturation from 85.7 ± 5.1 to 94.5 ± 3.6% (p < 0.05) and in minimum oxygen saturation from 64.7 ± 13.4 to 78.7 ± 13.7% (p < 0.05). The magnitude of the weight loss and the improvements in mean and minimum oxygen saturation were positively correlated, (r = 0.76; p ≤ 0.05, and r = 0.59; p ≤ 0.05, respectively). Conclusions: Weight loss achieved by bariatric surgery is associated with significant long-term improvements in obstructive respiratory event, oxygenation and resolution of daytime somnolence.

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Leptin and Ghrelin Levels in Patients with Obstructive Sleep Apnea Syndrome

Cited by 108 publications

References 40 publications

Leptin and Ghrelin Levels in Children before and after Adenoidectomy or Adenotonsillectomy

Leptin and Ghrelin Levels in Children before and after Adenoidectomy or Adenotonsillectomy

Resistin Is Closely Related to Systemic Inflammation in Obstructive Sleep Apnea

Bariatric Surgery in the Treatment of Obstructive Sleep Apnea in Morbidly Obese Patients

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