2008
DOI: 10.1590/s0365-05962008000100010
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Abstract: Leprosy reactions are a major cause of nerve damage and morbidity in a significant proportion of leprosy patients. Reactions are immunologically mediated and can occur even after successful completion of multi-drug therapy. This review focuses on the epidemiology, pathology and treatment of leprosy type 1 reactions, erythema nodosum leprosum and silent neuropathy.

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Cited by 75 publications
(108 citation statements)
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“…Assim os pacientes paucibacilares, não sujeitos à reação tipo II, estiveram menos expostos a complicações, mas é importante ressaltar que tal achado não é tranquilizador, pois essas reações são acompanhadas de neurite que é responsável por danos e sequelas importantes 1,9,13 .…”
Section: Agradecimentos Conflito De Interesseunclassified
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“…Assim os pacientes paucibacilares, não sujeitos à reação tipo II, estiveram menos expostos a complicações, mas é importante ressaltar que tal achado não é tranquilizador, pois essas reações são acompanhadas de neurite que é responsável por danos e sequelas importantes 1,9,13 .…”
Section: Agradecimentos Conflito De Interesseunclassified
“…A duração e o número desses surtos reacionais dependem muitas vezes da forma clínica, bem como do índice baciloscópico inicial 8,9 .…”
unclassified
“…This is a major concern because: 1) leprosy sequelae such as nerve function impairment and disabilities are in most cases linked to these episodes and 2) treatment of these episodes is based on prolonged use of drugs with potential severe side effects, such as corticosteroids and thalidomide. 1 These episodes represent an exacerbation of the inflammatory responses and can appear before, during, or after chemotherapy for Mycobacterium leprae. Two types of reactions are recognized, with distinct clinical and histopathological features.…”
Section: Introductionmentioning
confidence: 99%
“…Dr. Enéas de Carvalho Aguiar 470, São Paulo, SP, 05403, Brazil. E-mail: mahong@usp.br mechanisms, 1 it is clear that they both result from exacerbation of an ongoing immune response and, as such, from lack of immune regulation. However, the participation of Tregs in the development of leprosy reaction episodes remains unclear.…”
Section: Introductionmentioning
confidence: 99%
“…Leprosy presents a spectrum of immunological groups between the two poles, the tuberculoid pole (TT) with increased cell-mediated immunity, which gradients towards the lepromatous pole (LL) through a series of borderline forms (BT, BB and BL) with simultaneous increase in humoral immune response and increase in the bacillary load. Type1 Reaction (T1R) also called Reversal Reaction (RR), particularly occurs in BT through BL types of leprosy with exacerbations of the pre-existing skin and nerve lesions due to up-gradation of Cell-Mediated Immunity (CMI) more often during and after Multidrug Therapy (MDT) [2]. Dynamics of immunological reactions could reflect changes in the levels of certain circulatory molecules that could act as possible biomarkers for predicting reactions in leprosy (20).…”
Section: Discussionmentioning
confidence: 99%