Lepidium meyenii Walp (red maca) Supplementation Prevents Acrylamide-Induced Oxidative Stress and Liver Toxicity in Rats: Phytochemical Composition by UHPLC–ESI–MS/MS

Ybañez-Julca, Roberto O.; Palacios, Javier; Asunción-Alvarez, Daniel; Quispe-Díaz, Iván M.; Nwokocha, Chukwuemeka R.; Albuquerque, Ricardo Diego Duarte Galhardo de

doi:10.1007/s11130-022-01000-2

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…In addition, it is known that ROS oxidizes the lipids in the cell membrane, disrupts the integrity of the membrane, and causes the formation of toxic products such as MDA ( Li et al, 2015 ). Many studies are reporting that acrylamide increases MDA levels by causing lipid peroxidation ( Sadek, 2012 ; Ybañez-Julca et al, 2022 ). In our study, the MDA elevation in the acrylamide group supports the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Our study determined that rats treated with acrylamide due to liver damage had increased serum ALT and AST levels. Elevated serum ALT and AST levels are probably due to the leakage of these enzymes into the circulation as a result of cell membrane damage caused by oxidative stress ( Gedik et al, 2017 ; Ybañez-Julca et al, 2022 ). We found that ALT and AST levels approached normal values as a result of carvacrol administration.…”

Section: Discussionmentioning

confidence: 99%

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Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

et al. 2023

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Background: Acrylamide causes hepatotoxicity with the effect of oxidative stress and inflammatory processes. Carvacrol is a monoterpenic phenol with antioxidant and anti-inflammatory properties.Aims: To determine the effects of carvacrol on oxidative liver injury induced by acrylamide administration in rats.Methods: Rats were divided into three groups of six animals each: healthy group acrylamide group (ACR), and acrylamide + carvacrol group (TACR). First, carvacrol (50 mg/kg) was administered intraperitoneally to the CACR group. One hour later, acrylamide (20 mg/kg) was given orally to the ACR and CACR groups. This procedure was performed for 30 days, after which the animals were sacrificed. The malondialdehyde (MDA) and total glutathione (tGSH) levels, total oxidant (TOS) and total antioxidant status (TAS), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and nuclear factor kappa b (NF-κB) were measured in the excised liver tissues. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in blood serum samples. Liver tissues were also examined histopathologically.Results: In the ACR group, malondialdehyde, TOS, ALT, AST levels, and NF-κB, IL-1β, and TNF-α levels were found to be high, and tGSH and total antioxidant status levels were low. In addition, diffuse degenerative changes and necrosis in hepatocytes, and moderate inflammation in the portal region were detected in the liver tissues of the ACR group. While carvacrol prevented the biochemical changes induced by acrylamide, it also alleviated the damage in the histological structure.Conclusion: Carvacrol may be used for liver damage caused by acrylamide.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

et al. 2023

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“…In vitro studies evaluated the effect of different maca extracts on cells of the male reproductive system, including Sertoli cells ( Yoshida et al, 2018 ) and sperm ( Leiva-Revilla et al, 2022 ; Prete et al, 2022 ). The hydroalcoholic extract increased testosterone production by Leidig cells and was involved in steroidogenesis; however, this steroidogenic effect declined with increasing age ( Ybañez-Julca et al, 2022 ). The protective effect on sperm sample preservation was also evaluated, where maca extract in frozen sperm subjected to thawing showed a transient improvement in sperm motility, integrity and morphology, as well as an increase in acrosomal integrity and sperm vitality associated with a decrease in sperm DNA damage at 24 h ( Leiva-Revilla et al, 2022 ).…”

Section: Pharmacologymentioning

confidence: 99%

Section: Pharmacologymentioning

confidence: 99%

“…The antioxidant effect in vivo was evaluated in models of hepatic oxidative damage by OH ( Zhang et al, 2017b ) and acrylamide ( Ybañez-Julca et al, 2022 ), using the oral route. The aqueous extract was shown to decrease systemic levels of MDA (in erythrocytes, brain and liver), lipid peroxidation and liver transaminases (ALT, AST) ( Ybañez-Julca et al, 2022 ). On the other hand, the polysaccharide MP-1 also showed similar effects, adding the decrease in serum levels of triglycerides, LDL cholesterol, γ-glutamyltranpeptidase, and the increase of antioxidant liver enzymes (SOD, GSH-Px, glutathione S-transferase), in addition to decreasing histopathological liver alterations ( Zhang et al, 2017a ).…”

Section: Pharmacologymentioning

confidence: 99%

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Exploring the chemical and pharmacological variability of Lepidium meyenii: a comprehensive review of the effects of maca

Ulloa del Carpio,

Alvarado-Corella,

Quiñones-Laveriano

et al. 2024

Front. Pharmacol.

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Maca (Lepidium meyenii), a biennial herbaceous plant indigenous to the Andes Mountains, has a rich history of traditional use for its purported health benefits. Maca’s chemical composition varies due to ecotypes, growth conditions, and post-harvest processing, contributing to its intricate phytochemical profile, including, macamides, macaenes, and glucosinolates, among other components. This review provides an in-depth revision and analysis of Maca’s diverse bioactive metabolites, focusing on the pharmacological properties registered in pre-clinical and clinical studies. Maca is generally safe, with rare adverse effects, supported by preclinical studies revealing low toxicity and good human tolerance. Preclinical investigations highlight the benefits attributed to Maca compounds, including neuroprotection, anti-inflammatory properties, immunoregulation, and antioxidant effects. Maca has also shown potential for enhancing fertility, combating fatigue, and exhibiting potential antitumor properties. Maca’s versatility extends to metabolic regulation, gastrointestinal health, cardio protection, antihypertensive activity, photoprotection, muscle growth, hepatoprotection, proangiogenic effects, antithrombotic properties, and antiallergic activity. Clinical studies, primarily focused on sexual health, indicate improved sexual desire, erectile function, and subjective wellbeing in men. Maca also shows promise in alleviating menopausal symptoms in women and enhancing physical performance. Further research is essential to uncover the mechanisms and clinical applications of Maca’s unique bioactive metabolites, solidifying its place as a subject of growing scientific interest.

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Maca roots: A potential therapeutic in the management of metabolic disorders through the modulation of metabolic biochemical markers in rats fed high-fat high-carbohydrate diet

Mohamed,

Shalaby,

El-Shiekh

et al. 2024

Journal of Ethnopharmacology

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Lepidium meyenii Walp (red maca) Supplementation Prevents Acrylamide-Induced Oxidative Stress and Liver Toxicity in Rats: Phytochemical Composition by UHPLC–ESI–MS/MS

Cited by 6 publications

References 31 publications

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

Exploring the chemical and pharmacological variability of Lepidium meyenii: a comprehensive review of the effects of maca

Maca roots: A potential therapeutic in the management of metabolic disorders through the modulation of metabolic biochemical markers in rats fed high-fat high-carbohydrate diet

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