Lentigo Senilis

Perilesional vs. lesional skin changes in senile lentigo

“…In a systematic comparison of lesional vs. perilesional histopathologic changes, we confirmed the typical features of SL already noted by others 1,15,16 . Our investigation confirms the opinion of Montagna et al 17 .…”

“…In a systematic comparison of lesional vs. perilesional histopathologic changes, we confirmed the typical features of SL already noted by others. 1,15,16 Our investigation confirms the opinion of Montagna et al 17 that 'the complex and distinctive architecture of LS is probably the result of concurrent proliferation of melanocytes and keratinocytes.' Indeed, we counted a greater number of melanocytes in lesional skin, but the measure was done relative to length of stratum corneum, and this increase may rather express an increased length of basal layer than a significant melanocyte hyperplasia.…”

Perilesional vs. lesional skin changes in senile lentigo

“…In a systematic comparison of lesional vs. perilesional histopathologic changes, we confirmed the typical features of SL already noted by others 1,15,16 . Our investigation confirms the opinion of Montagna et al 17 .…”

“…In a systematic comparison of lesional vs. perilesional histopathologic changes, we confirmed the typical features of SL already noted by others. 1,15,16 Our investigation confirms the opinion of Montagna et al 17 that 'the complex and distinctive architecture of LS is probably the result of concurrent proliferation of melanocytes and keratinocytes.' Indeed, we counted a greater number of melanocytes in lesional skin, but the measure was done relative to length of stratum corneum, and this increase may rather express an increased length of basal layer than a significant melanocyte hyperplasia.…”

Skin Ultrastructure in Senile Lentigo

“…In a systematic comparison of lesional and perilesional histopathologic changes, we confi rmed the typical features of SL already noted by others [1,4,5] . Our investigation confi rms the opinion of Montagna et al [6] that 'the complex and distinctive architecture of SL is probably the result of concurrent proliferation of melanocytes and keratinocytes', but is also associated with a weakening of the dermal-epidermal junction ultrastructure.…”

Alterations in the epidermal-dermal melanin axis and factor XIIIa melanophages in senile lentigo and ageing skin

“…Besides an increase of melanin in the basal and, to a lesser extent, suprabasal layers of this epithelium, which is the basis for the clinical occurrence of SL, elongated rete ridges have been described by most authors. [1][2][3][4]10 The morphology of our samples was mostly in accordance with these findings confirming the clinical diagnosis histologically. The overall degree of rete ridge elongation, as quantified by the BM/E ratio, showed considerable overlap between perilesional and lesional skin (Fig.…”

“…Bar ¼ 100 lm (a-d). lesions compared with unaffected skin, as has been described elsewhere 2,4 (Fig. 2a-d).…”

Perilesional vs. lesional skin changes in senile lentigo

“…In a systematic comparison of lesional vs. perilesional histopathologic changes, we confirmed the typical features of SL already noted by others 1,15,16 . Our investigation confirms the opinion of Montagna et al 17 .…”

“…In a systematic comparison of lesional vs. perilesional histopathologic changes, we confirmed the typical features of SL already noted by others. 1,15,16 Our investigation confirms the opinion of Montagna et al 17 that 'the complex and distinctive architecture of LS is probably the result of concurrent proliferation of melanocytes and keratinocytes.' Indeed, we counted a greater number of melanocytes in lesional skin, but the measure was done relative to length of stratum corneum, and this increase may rather express an increased length of basal layer than a significant melanocyte hyperplasia.…”

Skin Ultrastructure in Senile Lentigo

“…In a systematic comparison of lesional and perilesional histopathologic changes, we confi rmed the typical features of SL already noted by others [1,4,5] . Our investigation confi rms the opinion of Montagna et al [6] that 'the complex and distinctive architecture of SL is probably the result of concurrent proliferation of melanocytes and keratinocytes', but is also associated with a weakening of the dermal-epidermal junction ultrastructure.…”

Alterations in the epidermal-dermal melanin axis and factor XIIIa melanophages in senile lentigo and ageing skin

“…Besides an increase of melanin in the basal and, to a lesser extent, suprabasal layers of this epithelium, which is the basis for the clinical occurrence of SL, elongated rete ridges have been described by most authors. [1][2][3][4]10 The morphology of our samples was mostly in accordance with these findings confirming the clinical diagnosis histologically. The overall degree of rete ridge elongation, as quantified by the BM/E ratio, showed considerable overlap between perilesional and lesional skin (Fig.…”

“…Bar ¼ 100 lm (a-d). lesions compared with unaffected skin, as has been described elsewhere 2,4 (Fig. 2a-d).…”

Perilesional vs. lesional skin changes in senile lentigo

“…In a systematic comparison of lesional vs. perilesional histopathologic changes, we confirmed the typical features of SL already noted by others 1,15,16 . Our investigation confirms the opinion of Montagna et al 17 .…”

“…In a systematic comparison of lesional vs. perilesional histopathologic changes, we confirmed the typical features of SL already noted by others. 1,15,16 Our investigation confirms the opinion of Montagna et al 17 that 'the complex and distinctive architecture of LS is probably the result of concurrent proliferation of melanocytes and keratinocytes.' Indeed, we counted a greater number of melanocytes in lesional skin, but the measure was done relative to length of stratum corneum, and this increase may rather express an increased length of basal layer than a significant melanocyte hyperplasia.…”

Skin Ultrastructure in Senile Lentigo

“…In a systematic comparison of lesional and perilesional histopathologic changes, we confi rmed the typical features of SL already noted by others [1,4,5] . Our investigation confi rms the opinion of Montagna et al [6] that 'the complex and distinctive architecture of SL is probably the result of concurrent proliferation of melanocytes and keratinocytes', but is also associated with a weakening of the dermal-epidermal junction ultrastructure.…”

Alterations in the epidermal-dermal melanin axis and factor XIIIa melanophages in senile lentigo and ageing skin

“…Besides an increase of melanin in the basal and, to a lesser extent, suprabasal layers of this epithelium, which is the basis for the clinical occurrence of SL, elongated rete ridges have been described by most authors. [1][2][3][4]10 The morphology of our samples was mostly in accordance with these findings confirming the clinical diagnosis histologically. The overall degree of rete ridge elongation, as quantified by the BM/E ratio, showed considerable overlap between perilesional and lesional skin (Fig.…”

“…Bar ¼ 100 lm (a-d). lesions compared with unaffected skin, as has been described elsewhere 2,4 (Fig. 2a-d).…”