Lensfree on-chip imaging using nanostructured surfaces

Khademhosseinieh, Bahar; Şencan, İkbal; Biener, Gabriel; Su, Ting‐Wei; Coşkun, Ahmet F.; Tseng, Derek; Özcan, Aydogan

doi:10.1063/1.3405719

Cited by 23 publications

(19 citation statements)

References 13 publications

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“…To this end, there have been efforts to create dual-mode lens-free microscopes that can switch back and forth between bright-field and fluorescence imaging 27 . However, the resolution and image quality of these existing lens-free fluorescence imaging solutions are not yet as competitive as those of their bright-field counterparts 26,28,58 . There are several reasons behind this limited performance of lens-free fluorescence imaging.…”

Section: Future Challenges and Opportunitiesmentioning

confidence: 99%

Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy

et al. 2012

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We discuss unique features of lens-free computational imaging tools and report some of their emerging results for wide-field on-chip microscopy, such as the achievement of a numerical aperture (NA) of ~0.8–0.9 across a field of view (FOV) of more than 20 mm2 or an NA of ~0.1 across a FOV of ~18 cm2, which corresponds to an image with more than 1.5 gigapixels. We also discuss the current challenges that these computational on-chip microscopes face, shedding light on their future directions and applications.

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Section: Future Challenges and Opportunitiesmentioning

confidence: 99%

Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy

et al. 2012

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“…However, the heat transfer between the sensor and the sample and other practical limitations such as contamination of the active region of the sensor-array also have to be considered. The use of compact optical elements, such as nanostructured surfaces [110] or tapered fiber optic faceplates [111] has been recently demonstrated, increasing the resolution of these wide field-of-view incoherent systems down to <4μm. These fluorescent imaging modalities can be combined with on-chip bright field methods to create multi-modal, and yet cost-effective and field-portable microscopy platforms that can perform both bright-field and fluorescence on-chip imaging.…”

Section: Lensfree Fluorescent Imaging On a Chipmentioning

confidence: 99%

On-Chip Biomedical Imaging

Gӧrӧcs

Özcan

2013

IEEE Rev. Biomed. Eng.

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Lab-on-a-chip systems have been rapidly emerging to pave the way toward ultra-compact, efficient, mass producible and cost-effective biomedical research and diagnostic tools. Although such microfluidic and micro electromechanical systems achieved high levels of integration, and are capable of performing various important tasks on the same chip, such as cell culturing, sorting and staining, they still rely on conventional microscopes for their imaging needs. Recently several alternative on-chip optical imaging techniques have been introduced, which have the potential to substitute conventional microscopes for various lab-on-a-chip applications. Here we present a critical review of these recently emerging on-chip biomedical imaging modalities, including contact shadow imaging, lensfree holographic microscopy, fluorescent on-chip microscopy and lensfree optical tomography.

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“…Moreover, the digital diagnostic information can be transmitted to and processed in remote medical centers through wireless networks, from which the follow-on instruction and treatment plan are to be provided. Due to the dominant popularity of cellphones worldwide, cell phone-based diagnostics could be a vital tool to improve health conditions in the developing countries or remote villages 22,92,143,168,186. In brief, the emerging concepts for point-of-care diagnostics, quickly evolving with customized enabling micro-nanotechnology, may play a leading role in future global health care.…”

Section: Out-of-cleanroom Micro-nanofabrication For Biomedical Applicmentioning

confidence: 99%

From Cleanroom to Desktop: Emerging Micro-Nanofabrication Technology for Biomedical Applications

Pan

Wang

2010

Ann Biomed Eng

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This review is motivated by the growing demand for low-cost, easy-to-use, compact-size yet powerful micro-nanofabrication technology to address emerging challenges of fundamental biology and translational medicine in regular laboratory settings. Recent advancements in the field benefit considerably from rapidly expanding material selections, ranging from inorganics to organics and from nanoparticles to self-assembled molecules. Meanwhile a great number of novel methodologies, employing off-the-shelf consumer electronics, intriguing interfacial phenomena, bottom-up self-assembly principles, etc., have been implemented to transit micro-nanofabrication from a cleanroom environment to a desktop setup. Furthermore, the latest application of micro-nanofabrication to emerging biomedical research will be presented in detail, which includes point-of-care diagnostics, on-chip cell culture as well as bio-manipulation. While significant progresses have been made in the rapidly growing field, both apparent and unrevealed roadblocks will need to be addressed in the future. We conclude this review by offering our perspectives on the current technical challenges and future research opportunities.

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Lensfree on-chip imaging using nanostructured surfaces

Cited by 23 publications

References 13 publications

Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy

Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy

On-Chip Biomedical Imaging

From Cleanroom to Desktop: Emerging Micro-Nanofabrication Technology for Biomedical Applications

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