From Cleanroom to Desktop: Emerging Micro-Nanofabrication Technology for Biomedical Applications

Pan, Tingrui; Wang, Wei

doi:10.1007/s10439-010-0218-9

Cited by 64 publications

(50 citation statements)

References 218 publications

(365 reference statements)

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“…They have direct applications such as prototype generation [1,27], flexible electronics [193,369], and point-of-care diagnostics [123,433]. Issues that need to be explored further include scalability, metallization, consistence, and compatibility due to nonstandard fabrication and material processing, as well as integration with large-scale systems [315].…”

Section: Novel Trends From Cleanroom To Desktopmentioning

confidence: 99%

Application of Nanoparticles in Manufacturing

Hu¹,

Tuck²,

Wildman³

et al. 2015

Handbook of Nanoparticles

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With the development of nanoscience and nanotechnology, manufacturing is undergoing revolutionary changes. Nanoparticles, due to their novel and often enhanced properties, are now more and more used in manufacturing. In this chapter, the state-of-the-art application of nanoparticles in manufacturing is reviewed. The contents include five parts: (a) role of nanoparticles in manufacturing, (b) manufacturing methods, (c) applications, (d) challenges, and (e) conclusions. The roles of nanoparticles are divided into three categories: (i) building blocks, being the major component of a manufactured product by solid-state or colloidal nanoparticle consolidation; (ii) functional filler, as an addition for functionality, such as property improver, catalyst, stimuli-responsive, sensing, imaging, and carrier; and (iii) nanocomposites for multifunctionality. Various manufacturing methods and novel trends are summarized in this chapter, including top-down and bottom-up, from 2D to 3D, from cleanroom to desktop, 3D printing, and bio-assisted methods, such as DNA origami. Direct applications in areas of flexible electronics, molecular electronics, solar cells, construction industry, water treatment, and biomedical devices are presented. The associated challenges including nanoparticle safety issue, sustainable manufacturing, economic issue, and scale-up are discussed. Role of Nanoparticles in ManufacturingWith the development of nanoscience and nanotechnology, manufacturing is undergoing revolutionary changes. Nanoparticles, due to their novel and often enhanced properties, have more and more been used in various manufacturing applications. Their role can generally be divided into three categories: (a) building blocks, (b) functional filler, and (c) nanocomposites for multifunctionality, which is summarized in Table 1. Building BlockNanoparticles sometimes act like the bricks in a house-building process to be the main component of a manufactured product. They can be consolidated via solid-and liquid-based methods. Solid-State Nanoparticle ConsolidationSolid-state metallic, ceramic, amorphous, and compound particles can be thermomechanically processed to form bulk 2D/3D structures with desired strength and level of densification (even full densification is possible). Reported methods include powder compact forging/extrusion, equal channel angular extrusion/ pressing, and hot pressing/sinter forging combined with conventional heating, laser sintering, microwave sintering, electric discharge sintering, or spark plasma sintering [33,255,278,306,425,426,476,492]. Particles with a narrow size distribution and spherical shape are desired to achieve low pore-to-

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Section: Novel Trends From Cleanroom To Desktopmentioning

confidence: 99%

Application of Nanoparticles in Manufacturing

Hu¹,

Tuck²,

Wildman³

et al. 2015

Handbook of Nanoparticles

View full text Add to dashboard Cite

show abstract

“…Most biomarker testing is currently taking place at centralized dedicated laboratories using large, automated analyzers, which increases both the analytical times and their associated costs. Accordingly, there is an urgent need in the clinical laboratory for smaller, faster, and cheaper devices in order to make analytical results available with high accuracy at the patient's bedside (point-of-care diagnostics) [90,91]. The development of devices based on miniaturized microfluidic technologies (e.g., LC or CE in conventional format or in microchip format) coupled to immunological platforms is one of the most promising ways to solve some of the problems concerning the increasing need to develop highly sensitive, fast, and economic methods of analysis in medical diagnostics (Table 1) [92][93][94].…”

Section: Iace For the Quantification Of Predictive Biomarkersmentioning

confidence: 99%

Immunoaffinity capillary electrophoresis: A new versatile tool for determining protein biomarkers in inflammatory processes

Guzman¹,

Phillips

2011

Electrophoresis

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Many diseases caused by inflammatory processes can progress to a chronic state causing deterioration in the quality of life and a poor prognosis for long-term survival. To address inflammatory diseases effectively, early detection and novel therapeutics are required. However, this can be challenging, in part because of the lack of early predictive biomarkers and the limited availability of adequate technologies capable of the identification/characterization of key predictive biomarkers present in biological materials, especially those found at picomolar concentrations and below. This review highlights the need for state-of-the art methodologies, with high-sensitivity and high-throughput capabilities, for determination of multiple biomarkers. Although many new biomarkers have been discovered recently, existing technology has failed to successfully bring this advancement to the patient's bedside. We present an overview of the various advances available today to extend the discovery of predictive biomarkers of inflammatory diseases; in particular, we review the technology of immunoaffinity capillary electrophoresis (IACE), which combines the use of antibodies as highly selective capture agents with the high resolving power of capillary electrophoresis. This two-dimensional hybrid technology permits the quantification and characterization of several protein biomarkers simultaneously, including subtle structural changes such as variants, isoforms, peptide fragments, and post-translational modifications. Furthermore, the results are rapid, sensitive, can be performed at a relatively low cost, without the introduction of false positive or false negative data. The IACE instrumentation can have relevance to medical, pharmaceutical, environmental, military, cultural heritage (authenticity of art work), forensic science, industrial and research fields, and in particular as a point-of-care biomarker analyzer in translational medicine.

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“…16 CTS nanoparticles (CTS-NP) have also received much attention as the carriers for various drugs. 17 However, the effects of CTS microparticles (CTS-MP) and CTS-NP on antiobesity have not been reported.…”

Section: Introductionmentioning

confidence: 99%

Effects of chitosan and water-soluble chitosan micro- and nanoparticles in obese rats fed a high-fat diet

Zhang¹,

Zhong²,

Yi³

et al. 2012

IJN

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Purpose: This study determined the effects of chitosan (CTS) and water-soluble chitosan (WSC) microparticles (MPs) and nanoparticles (NPs) in rats with high-fat diet-induced obesity. Methods: The rats were randomly separated into eight groups: a normal diet group (the blank control), a high-fat emulsion group (the negative control), CTS and WSC control groups, CTS-MP and WSC-MP groups, and CTS-NP and WSC-NP groups. All groups (except the blank control group) were fed the high-fat diet for 4 weeks to establish the obesity model. Different samples were administered orally once daily to the treatment groups for 4 weeks. Results: A significantly lower weight gain was observed in the WSC-MP and WSC-NP groups, as well as in the CTS-MP and CTS-NP groups, compared with rats given a normal diet and a high-fat diet (P , 0.05). The WSC-MP rats had the least weight gain among all the groups. The food intake in the eight groups had the same trend as weight gain. CTS and WSC MPs and NPs significantly reduced the final amounts of epididymal and perirenal white adipose tissue. Liver weight was reduced in the CTS-MP group compared to rats fed a high-fat diet. Serum total cholesterol and low-density lipoprotein cholesterol were significantly reduced in all treatment groups, with the WSC-MP and CTS-MP groups showing a more significant reduction than the other groups. Triacylglycerol levels were significantly reduced in the WSC-NP group compared to the high-fat group. The mortality rates of CTS-MP, CTS-NP, WSC-MP, and WSC-NP groups were 30%, 30%, 55%, and 65%, respectively. The median lethal dose for the WSC-MP and WSC-NP groups were 4080 mg/kg and 2370 mg/kg, respectively. Conclusion: These results indicate that CTS and WSC MPs and NPs have greater effects than commercially available CTS and WSC, and can be used as potential antiobesity agents.

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From Cleanroom to Desktop: Emerging Micro-Nanofabrication Technology for Biomedical Applications

Cited by 64 publications

References 218 publications

Application of Nanoparticles in Manufacturing

Application of Nanoparticles in Manufacturing

Immunoaffinity capillary electrophoresis: A new versatile tool for determining protein biomarkers in inflammatory processes

Effects of chitosan and water-soluble chitosan micro- and nanoparticles in obese rats fed a high-fat diet

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From Cleanroom to Desktop: Emerging Micro-Nanofabrication Technology for Biomedical Applications

Cited by 64 publications

References 218 publications

Application of Nanoparticles in Manufacturing

Application of Nanoparticles in Manufacturing

Immunoaffinity capillary electrophoresis: A new versatile tool for determining protein biomarkers in inflammatory processes

Effects of chitosan and water-soluble chitosan micro-&nbsp;and nanoparticles in obese rats fed a high-fat diet

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Product

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Effects of chitosan and water-soluble chitosan micro- and nanoparticles in obese rats fed a high-fat diet