Lens Epithelial Cell Migration between Posterior Capsule and Intraocular Lens with Variously Finished Posterior Optic Edge and Two Haptic Angulations

Ayaki, Masahiko; Ishida, Yoshiko; Nishimura, Eiichi; Yaguchi, Shigeo

doi:10.1159/000072147

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…PCO occurs when residual LECs migrate onto the previously cell-free posterior capsule, in response to the surgical trauma and implantation of an IOL, Fig. 1 [63]. In a further rabbit study by Nishi et al no differences were seen in PCO rates when comparing two square edge design IOLs, the hydrophobic acrylic IOL (Alcon AcrySof Ò MA60BM) and the 3-piece silicone IOL (Pharmacia CeeOnTM 911) [64].…”

Section: Cornea and Conjunctivamentioning

confidence: 99%

Biomaterials for ocular reconstruction

2014

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Synthetic materials have played a significant role in ophthalmic applications to improve vision for many years. This has been in four main areas in ophthalmology: ocular surface reconstruction, lens replacement, vitreous replacement and structural support and cell transplantation in the retina. Corneal replacement therapies have been developed using both synthetic acrylic-based materials and more recently naturally derived materials such as amniotic membrane.

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Section: Cornea and Conjunctivamentioning

confidence: 99%

Biomaterials for ocular reconstruction

2014

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“…In addition to the optic edge, it has been observed that the haptic angulation also reduces the incidence of PCO by inducing a pressure gradient over the posterior capsule (111).…”

Section: Iol Designmentioning

confidence: 99%

Post-operative Capsular Opacification: A review

Vasavada,

Raj,

Kaid

et al. 2007

Int. J Biomed Sci.

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Post-operative capsular opacification is a multifactorial physiological consequence of cataract surgery. Opacification involving the central posterior capsule has a significant impact on high and low contrast acuity and low contrast sensitivity. The assessment of Posterior Capsule Opacification (PCO) on cadaver eyes, experimental studies, culture models and in clinical studies has provided an understanding of its pathogenesis. The proliferation, migration and abnormal differentiation of residual lens epithelial cells and fibers in the capsular bag have been implicated in the pathogenesis of PCO. The incidence and severity of PCO correlates to the meticulous use of surgical techniques, IOL optic edge designs and IOL materials. This article summarizes the clinical studies with recommendations for retarding the development of central PCO. It discusses experiments with pharmacological agents broadly categorized as anti-inflammatory, immuno-modulating, antiproliferative, antiadhering, antitransdifferentiating agents for the prevention of PCO. These studies will remain critical for future endeavors undertaken for eradication of PCO.

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“…One approach has been to use the IOL design to physically impede the migration of residual LEC along the posterior wall of the lens capsule 3. AcrySof, an acrylate IOL (Alcon), and CeeOn Edge, a silicone IOL (Pharmacia), have sharp optic edges designed to exert contact pressure on the posterior capsule when they unfold, and this has been shown to lower the incidence of PCO clinically 4–10. A second approach involves modification of the chemistry of the IOL material to prevent the adhesion and proliferation of LEC.…”

Section: Introductionmentioning

confidence: 99%

Vitronectin is significant in the adhesion of lens epithelial cells to PMMA polymers

Evans

Hélary

Legeais

et al. 2004

J Biomedical Materials Res

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A major complication of intraocular lens surgery is diminished visual acuity caused by the regrowth of lens epithelial cells (secondary cataract). Polymethylmethacrylate (PMMA) is a commonly used intraocular lens material. This study addresses the mechanisms underlying the initial adhesion of lens epithelial cells to PMMA and a functionalized PMMA-based terpolymer known to inhibit cell proliferation. Rabbit lens epithelial cells were cultured on the test polymer surfaces in medium containing serum depleted of either fibronectin or vitronectin (or both) to identify the role of these proteins in the initial process of cell adhesion. Adherent cells were quantitated after 60 min, and the actin cytoskeleton and focal contact formation were compared in each serum treatment on both polymers. Vitronectin was significantly more effective for initial cell attachment to both polymers than fibronectin. Normal cell spreading on PMMA required vitronectin and was independent of fibronectin, whereas cell spreading on the terpolymer was abnormal and required the presence of fibronectin and vitronectin together. Together, these results help to explain the inhibition of cell proliferation previously shown on the functionalized PMMA. This work contributes to the design of a polymer for use in intraocular lenses that inhibits proliferation of the target cells.

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Lens Epithelial Cell Migration between Posterior Capsule and Intraocular Lens with Variously Finished Posterior Optic Edge and Two Haptic Angulations

Cited by 8 publications

References 19 publications

Biomaterials for ocular reconstruction

Biomaterials for ocular reconstruction

Post-operative Capsular Opacification: A review

Vitronectin is significant in the adhesion of lens epithelial cells to PMMA polymers

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