Lenient versus Strict Rate Control in Patients with Atrial Fibrillation

Gelder, Isabelle C. Van; Groenveld, Hessel F.; Tuininga, Ype S.; Alings, A. Marco; Hillege, Hans L.; Bergsma-Kadijk, J.A.; Cornel, Jan H.; Kamp, Otto; Tukkie, Raymond; Bosker, Hans A.; Veldhuisen, Dirk J. van; Berg, Maarten P. van den

doi:10.1056/nejmoa1001337

Cited by 860 publications

(561 citation statements)

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“…560,561 Similar results were found in a pooled analysis of the AFFIRM (Atrial Fibrillation Follow-up Investigation of Rhythm Management) and RACE trials (1091 participants), albeit with smaller heart rate differences and without randomization. 562 It is worthwhile to note that many 'adequately rate-controlled' patients (resting heart rate 60-100 b.p.m.)…”

Section: Heart Rate Targets In Atrial Fibrillationsupporting

confidence: 58%

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof¹,

Benussi²,

Kotecha³

et al. 2016

Eur J Cardiothorac Surg

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Section: Heart Rate Targets In Atrial Fibrillationsupporting

confidence: 58%

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof¹,

Benussi²,

Kotecha³

et al. 2016

Eur J Cardiothorac Surg

Self Cite

914

625

View full text Add to dashboard Cite

“…docelowej częstości rytmu komór < 110/min. Nie stwierdzono różnicy łącznej częstości występowania incydentów klinicznych (14,9% w grupie ścisłej kontroli częstości rytmu komór vs. 12,9% w grupie mniej rygorystycznej kontroli częstości rytmu komór) [560], klasy NYHA ani częstości hospitalizacji [560,561]. Podobne wyniki uzyskano w łącznej analizie badań Atrial Fibrillation Follow--up Investigation of Rhythm Management (AFFIRM) i RACE (1091 uczestników), choć w tej analizie różnica częstości rytmu komór była mniejsza i nie prowadzono randomizacji do grup o różnej docelowej częstości rytmu [562].…”

Section: Docelowa Częstość Rytmu Komórunclassified

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof

Benussi

Kotecha³

et al. 2016

Kardiol Pol

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“…3,4) Accordingly, rate control has been adopted as a front-line therapy in the management of AF. 5) AF, however, is also more strongly associated with poor mortality and morbidity due to congestive heart failure and stroke, compared to sinus rhythm (SR). The mortality risk gets much worse when AF develops in patients with heart failure.…”

mentioning

confidence: 99%

Prognostic Value of Cardiopulmonary Exercise Testing in Cardiac Patients With Atrial Fibrillation

et al. 2012

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SummaryParameters obtained from cardiopulmonary exercise testing (CPX) are recognized for their high prognostic value in predicting future cardiac events in cardiac patients. Our group compared the prognostic value of CPX parameters between patients with sinus rhythm (SR) and patients with atrial fibrillation (AF).Peak O2 uptake (VO2), the ratio of the increase in VO2 to the increase in work rate ( ∆VO2/ ∆WR), and the slope of the increase in ventilation to the increase in CO2 output (VE-VCO2 slope) were obtained from CPX in 72 AF patients and 478 SR patients. The prognostic values of these indices were compared between the two groups.Six cardiac deaths and 25 cardiac events were observed in the AF group and 9 cardiac deaths and 96 cardiac events were observed in the SR group, over a prospective follow-up period of 1,192 days. The percentages of cardiac deaths and cardiac events were higher in the AF group than in the SR group. In a multivariate Cox proportional hazards analysis, peak VO2 was identified as a sole significant predictor of cardiac death and cardiac events in SR patients and VE-VCO2 slope was identified as a sole significant predictor of cardiac death and cardiac events in AF patients.Our results suggest that the VE-VCO2 slope is strongly predictive of future cardiac events in patients with AF and that peak VO2 is strongly predictive of future cardiac events in SR patients. (Int Heart J 2012; 53: 102-107)

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Lenient versus Strict Rate Control in Patients with Atrial Fibrillation

Abstract: In patients with permanent atrial fibrillation, lenient rate control is as effective as strict rate control and is easier to achieve. (ClinicalTrials.gov number, NCT00392613.)

Cited by 860 publications

References 18 publications

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Prognostic Value of Cardiopulmonary Exercise Testing in Cardiac Patients With Atrial Fibrillation

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