Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in β-Oxidation in Mouse White Adipose Tissue

Fukuchi, Yoshiko; Hiramitsu, Masanori; Okada, Masahisa; Hayashi, Sanae; Nabeno, Yuka; Osawa, Toshihiko; Naito, Michitaka

doi:10.3164/jcbn.2008066

Cited by 81 publications

(58 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous research examining the effect of polyphenols supplementation showed significantly up-regulated the acyl-CoA oxidase (ACO) mRNA level in epididymal fat [40]. In our study, quercetin group showed increased ACOX expression in skeletal muscle.…”

Section: Discussionsupporting

confidence: 61%

Exercise, but not quercetin, ameliorates inflammation, mitochondrial biogenesis, and lipid metabolism in skeletal muscle after strenuous exercise by high-fat diet mice

Kwon

Park

Jun

et al. 2014

Journal of Exercise Nutrition and Biochemistry

View full text Add to dashboard Cite

[Purpose]The purpose of this study was to investigate whether moderate exercise and quercetin intake with a low fat diet contribute to inflammatory cytokine production, mitochondrial biogenesis, and lipid metabolism in skeletal muscle after strenuous exercise by high-fat diet mice.[Methods]Male C57BL/6 mice were randomly divided into four groups: (1) High-fat for 12 weeks and low-fat diet control (C; n = 6); (2) high-fat diet for 12 weeks and low-fat diet with quercetin (Q; n = 4); (3) high-fat diet for 12 weeks and low-fat diet with exercise (E; n = 4); or (4) high-fat diet for 12 weeks and low-fat diet with exercise and quercetin (EQ; n = 5). Quercetin (10 mg/kg) was administered once per day, 5 day/week for 8 weeks. Exercise training was performed at moderate intensity for 8 weeks, 5 days/week for 30–60 min/day. Mice were subjected to a strenuous exercise bout of 60 min at a speed of 25 m/min (VO2 max 85%) conducted as an exercise-induced fatigue just before sacrifice.[Results]As results, body weights were significantly different among the groups. Exercise training significantly reduced inflammatory cytokines after strenuous exercise in skeletal muscle of high-fat diet mice. Exercise training increased Tfam mRNA in the soleus muscle after strenuous exercise. Exercise training significantly decreased lipogenesis markers in skeletal muscle of obese mice after strenuous exercise. Moderate exercise significantly increased lipolysis markers in the tibialis anterior muscle.[Conclusion]These findings suggest that exercise training reduced inflammatory cytokine levels and improved mitochondrial biogenesis and lipid metabolism. However quercetin supplementation did not affect these parameters. Thus, long-term moderate exercise training has positive effects on obesity.

show abstract

Section: Discussionsupporting

confidence: 61%

Exercise, but not quercetin, ameliorates inflammation, mitochondrial biogenesis, and lipid metabolism in skeletal muscle after strenuous exercise by high-fat diet mice

Kwon

Park

Jun

et al. 2014

Journal of Exercise Nutrition and Biochemistry

View full text Add to dashboard Cite

show abstract

“…Among all polyphenol compounds, chlorogenic acid-or quercetin-containing apple products have been shown to have anti-obesity effects in HFD-induced obesity [30,31]. Fukuchi et al [46] indicated that citrus bioactive phenolics were reported to promote less body weight gain and white adipose tissue gain in mice after feeding of a HFD. Acetic acid is a major ingredient of vinegar, representing 6% of vinegar by volume, and it has also been shown to affect metabolic regulation and to have weight-reducing effects and alleviate hyperlipidemia [17,19,20,26,27].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Anti-obesity Effects of Spirit Vinegar and Natural Fermented Vinegar Products on the Differentiation of 3T3-L1 Cells and Obese Rats Fed a High-fat Diet

Son¹,

Kim²,

Shin³

et al. 2017

JFNR

View full text Add to dashboard Cite

This study aimed to compare the effects of spirit vinegar and four types of natural fermented vinegar products (apple vinegar, brown rice vinegar, lemon vinegar, and balsamic vinegar) on the differentiation of 3T3-L1 cells and obesity in rats fed a high-fat diet (HFD). Vinegar inhibited the accumulation of lipid droplets during the differentiation of 3T3-L1 cells. Body weight gains, visceral fat pad weights, serum leptin and triglyceride levels, and hepatic lipogenic enzyme mRNA levels were significantly decreased in the HF-vinegar administered groups compared with those in the HF group. Furthermore, oral administration of vinegars significantly reduced the occurrence of fatty liver deposits and steatosis, and inhibited the HF diet-induced increase in adipocyte size. The anti-obesity and lipid-lowering effects were slightly greater in the HF-natural fermented vinegar groups than in the HF-spirit vinegar group. Apple vinegar had the strongest anti-obesity effects in 3T3-L1 cells and obese rats compared with the other tested vinegars. These findings indicated that vinegar administration may have potential for improving some obesity-related parameters in 3T3-L1 cells and obese rats.

show abstract

“…Body weight gain, fat accumulation, and the development of hyperlipidemia, hyperglycemia, and insulin resistance were significantly suppressed by lemon polyphenols in mice fed a highfat diet (53). Lemon polyphenols suppressed diet-induced obesity by upregulation of mRNA levels of the enzymes involved in b-oxidation, such as peroxisome proliferator activated receptor (PPAR) a, acyl-CoA oxidase, FA synthase in liver, and white adipose tissue in mice (53). Naringenin supplementation (0.003%, 0.006%, and 0.012% of the diet for 6 wk) lowered adiposity and TG contents in parametrial adipose tissue in rats (54).…”

Section: Effect Of Naringin On Obesitymentioning

confidence: 98%

“…High body fat also increases the risk of several diseases such as diabetes, hyperlipidemia, and hypertension, which leads to arteriosclerotic disease and metabolic syndrome (52). Body weight gain, fat accumulation, and the development of hyperlipidemia, hyperglycemia, and insulin resistance were significantly suppressed by lemon polyphenols in mice fed a highfat diet (53). Lemon polyphenols suppressed diet-induced obesity by upregulation of mRNA levels of the enzymes involved in b-oxidation, such as peroxisome proliferator activated receptor (PPAR) a, acyl-CoA oxidase, FA synthase in liver, and white adipose tissue in mice (53).…”

Section: Effect Of Naringin On Obesitymentioning

confidence: 99%

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

Alam¹,

Subhan²,

Rahman³

et al. 2014

Advances in Nutrition

596

340

View full text Add to dashboard Cite

Flavonoids are important natural compounds with diverse biologic activities. Citrus flavonoids constitute an important series of flavonoids. Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities. Several lines of investigation suggest that naringin supplementation is beneficial for the treatment of obesity, diabetes, hypertension, and metabolic syndrome. A number of molecular mechanisms underlying its beneficial activities have been elucidated. However, their effect on obesity and metabolic disorder remains to be fully established. Moreover, the therapeutic uses of these flavonoids are significantly limited by the lack of adequate clinical evidence. This review aims to explore the biologic activities of these compounds, particularly on lipid metabolism in obesity, oxidative stress, and inflammation in context of metabolic syndrome.

show abstract

Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in β-Oxidation in Mouse White Adipose Tissue

Cited by 81 publications

References 49 publications

Exercise, but not quercetin, ameliorates inflammation, mitochondrial biogenesis, and lipid metabolism in skeletal muscle after strenuous exercise by high-fat diet mice

Exercise, but not quercetin, ameliorates inflammation, mitochondrial biogenesis, and lipid metabolism in skeletal muscle after strenuous exercise by high-fat diet mice

Comparison of Anti-obesity Effects of Spirit Vinegar and Natural Fermented Vinegar Products on the Differentiation of 3T3-L1 Cells and Obese Rats Fed a High-fat Diet

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

Contact Info

Product

Resources

About