Lemierre's syndrome caused by <i>Klebsiella pneumoniae:</i> A case report

Hwang, So Yeon; Shin, Seok Joon; Yoon, Hye Eun

doi:10.5527/wjn.v10.i5.101

Cited by 3 publications

(9 citation statements)

References 16 publications

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“…Unlike the classical presentation of Lemierre’s syndrome, which predominantly occurs in adolescents and young adults, particularly males [ 1 , 5 , 8 - 10 ]. Consistent with previous literature, the incidence of KLS is closely linked to a history of DM [ 7 , 9 - 13 ]. In our analysis, approximately 77% (n = 10) of the patients either had DM or had recently been diagnosed with it.…”

Section: Discussionsupporting

confidence: 89%

“…Similarly to classical Lemierre's syndrome, pulmonary metastasis remains the most common manifestation [ 8 - 10 , 15 ]. In earlier cases of Lemierre's syndrome, about 10% of the patients required mechanical ventilator support [ 13 ]. However, our statistics indicate a notably higher rate, with 31% (n=4) of KLS cases necessitating mechanical ventilator support.…”

Section: Discussionmentioning

confidence: 99%

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Lemierre’s Syndrome Caused by Klebsiella pneumoniae: A Case Report and Literature Review

Chen,

Chuang,

Lin

et al. 2023

Cureus

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Lemierre's syndrome is a rare condition that involves anaerobic sepsis following pharyngitis and is characterized by a high mortality rate. It often manifests as a septic embolism within the internal jugular vein due to oropharyngeal infections, leading to vein wall inflammation. Despite modern antibiotics, Lemierre's syndrome remains underdiagnosed and poses a significant threat. We report the case of a 43-year-old man who has alcoholic liver cirrhosis and diabetes mellitus. Symptoms included chest pain, back pain, and neck swelling, with Klebsiella pneum oniae leading to the diagnosis of K. pneumoniae- associated Lemierre’s syndrome. Furthermore, K. pneumoniae- associated Lemierre's syndrome is linked to diabetes mellitus and the elderly population. Notably, it showed a tendency for distant metastases, particularly in the lungs and brain. Additionally, central nervous system and renal involvement were observed in a smaller subset of cases.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Lemierre’s Syndrome Caused by Klebsiella pneumoniae: A Case Report and Literature Review

Chen,

Chuang,

Lin

et al. 2023

Cureus

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“…There are isolated case reports of resistant Klebsiella pneumonia causing LS, and phagocytic resistance has been suggested as the mechanism of resistance of certain capsular serotypes. 12 While S. pyogenes is considered universally sensitive to penicillin and ampicillin because of lack of beta-lactamase production, regular surveillance of antimicrobial resistance in LS should be conducted. 13 …”

Section: Discussionmentioning

confidence: 99%

Lemierre’s syndrome: A rare complication of acute bacterial pharyngitis

Joubert,

Moosa

2024

Southern African Journal of Infectious Diseases

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Lemierre’s syndrome is a rare clinical syndrome of septic thrombophlebitis following a bacterial oropharyngeal infection. Lemierre’s syndrome can be difficult to recognise and has significant morbidity. We report the case of a young man with Lemierre’s syndrome caused by Streptococcus pyogenes, who responded well to 2 weeks of beta-lactam therapy.Contributions: This case report summarises the key presenting features of Lemierre’s syndrome and provides a brief literature review considering the South African context.

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“…Lemierre’s syndrome is an extremely rare complication of bacterial pharyngitis and tonsillitis that involves an extension of the infection that results in septic thrombophlebitis of the internal jugular vein(s) [ 1 ]. This septic thrombophlebitis often embolizes and affects multiple organ systems, most commonly the lungs [ 2 - 3 ]. Amongst the reported cases, 90% of patients are between the age of 19-22 with a worldwide incidence of 1/1,000,000 [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Lemierre’s syndrome is commonly caused by Fusobacterium necrophorum, though other bacteria have been indicated. Often referred to as a ‘forgotten disease’, Lemierre’s syndrome has seen a rise in cases over the years secondary to increased antibiotic resistance [ 2 ]. Clinicians should be aware of this very rare and deadly disease as prompt initiation of treatment is vital in patient outcomes.…”

Section: Introductionmentioning

confidence: 99%