Leishmaniosis phytotherapy: Review of plants used in Iranian traditional medicine on leishmaniasis

Bahmani, Mahmoud; Saki, Kourosh; Ezatpour, Behrouz; Shahsavari, Somayeh; Eftekhari, Zohre; Jelodari, Mahyar; Rafieian-Kopaei, Mahmoud; Sepahvand, Reza

doi:10.1016/j.apjtb.2015.05.018

Cited by 29 publications

(21 citation statements)

References 60 publications

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“…48 Allium sativum is also widely used in infectious disease treatments. 19 The results obtained in our laboratory showed that Allium sativum was able to prevent the Artesunate toxicity in majority of parameters. Further, it was noted that high dose Artesunate toxicity was not totally prevented by 100 mg/kg Allium sativum implicating that the ameliorative agent dose needs to be reevaluated by increasing the dosage to combat high dose toxicity of Artesunate.…”

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confidence: 76%

“…13 Some contrary reports are available where studies have shown a spermicidal effect of Allium sativum 14 on one hand, while others have reported its beneficial effects in the recovery of testicular functions. 15 Moreover, Allium sativum is a mood elevating and hepato-protective agent 16 which is also protective against protozoan infections [17][18][19][20] and reduces platelet aggregation. [13][14][15][16][17][18][19][20][21] The active compounds of Allium sativum are volatile oil, sulphur, iodine, zinc, manganese, phosphorus, potassium, selenium, vitamin A, vitamins B 1 , B 2 and B 6 and vitamin C. In addition to various antioxidants, it also contains more than eighty sulfur-containing compounds.…”

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confidence: 99%

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2017

IJPSR

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ABSTRACT:In recent times, the use of natural antioxidants as ameliorative agents has become the focus of basic research. Allium sativum (garlic) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the induced renal toxicity of the antimalarial drug, artesunate, which has been used as an alternative antimalarial drug against conventional drugs like chloroquine. Thirty six male mice were divided into six experimental groups. In the present study, Allium sativum was given at 100 mg/kg body weight with low dose (150 mg/kg body weight) and high dose (300 mg/kg body weight) of artesunate for 14 days and 21 days duration. Obtained results showed significant alterations in gravimetric indices as well as biochemical parameters. Moreover, administration of Allium sativum exhibited recovery and reestablishment of various altered indices in renal tissue as opposed to artesunate treated groups. This study obviously demonstrated that treatment with Allium sativum significantly attenuated the renal toxicity induced by artesunate in Mus musculus. Thus, it can be concluded from the observed results that Allium sativum could be used as a potent mitigating agent against antimalarial drug toxicity.

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confidence: 76%

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confidence: 99%

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2017

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“…[1] However, some manufacturers have illegally adulterated SHPs with one or more synthetic compounds to reap huge profits. In particular, slimming herbal products (SHPs) sold over the counter are considered particularly attractive, because they are often advertised as dietary supplements containing purely 'natural ingredients'.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, slimming herbal products (SHPs) sold over the counter are considered particularly attractive, because they are often advertised as dietary supplements containing purely 'natural ingredients'. [1] However, some manufacturers have illegally adulterated SHPs with one or more synthetic compounds to reap huge profits. [2] The presence of chemical adulterants may cause severe harm to patients who continuously take high doses of illicit SHPs.…”

Section: Introductionmentioning

confidence: 99%

Two‐dimensional correlation infrared spectroscopy applied to the identification of ephedrine and pseudoephedrine in illegally adulterated slimming herbal products

Liu

et al. 2016

Drug Testing and Analysis

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Two-dimensional correlation spectroscopy (2DCOS) was employed for the identification of ephedrine (Ep) and pseudoephedrine (Ps) present in illegally adulterated slimming herbal products (SHPs). Second derivative (SD) spectral pretreatment was used prior to 2DCOS analysis to highlight specific features not readily observable by Fourier transform infrared spectroscopy (FTIR), SD-FTIR, or original 2DCOS, leading to enhanced resolution and a reduced lower limit of detection (<1% in this study). After examining the power spectra of suspicious SHPs, bands containing characteristic peaks for Ep (701, 747, 1042, 1363, 1375, 1451, 1478 cm etc) and/or Ps (703, 767, 1037, 1375, 1428, 1455, 1590 cm 1, etc.) were selected to construct synchronous and asynchronous maps for further analysis, while the latter was applied to discriminate positive SHPs adulterated simultaneously with Ep and Ps. The proposed method is simple and economical and has the potential to identify other chemicals in illegally adulterated herbal products. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Since the victims of leishmaniasis are generally poor, many patients pick out herbal therapy which is inexpensive and readily available [23,24]. The anti-leishmanial activity of some plants is related to the presence of the compounds such as alkaloids, chalcones, triterpenoids, naphthoquinones, quinones, terpenes, steroids, lignans, saponins, and flavonoids [24].…”

Section: Introductionmentioning

confidence: 99%