Leishmanicidal and antimicrobial activity of primin and primin-containing extracts from Miconia willdenowii

Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata

“…Previous phytochemical investigations of Miconia species resulted in isolation of triterpenes (Cunha et al, 2017), flavonoids (Lima et al, 2018), tannins (Rodrigues et al, 2011), and quinone compounds (Viegas et al, 2019). The antimicrobial activity of extracts from Miconia species has been reported in the literature to be active against several microorganisms (Gontijo et al, 2019).…”

Biological activity and chemical composition of the ethanolic extracts of Miconia ferruginata DC. / Atividade biológica e composição química dos extratos etanólicos de Miconia ferruginata DC.

“…The antitripanosomatides assay did also not show activity of EELF extract against the species evaluated. However, in previous studies, the isolate compounds of species of the genus Miconia sp., such as ursolic acid and oleanoic acid, showed potent activities tripanocidal (Cunha et al, 2006;Paduch et al, 2007;da Silva Ferreira et al, 2013), leishmanicidal (Peixoto et al, 2011;Viegas et al, 2019) and antibacterial (Cunha et al, 2010;Gontijo et al, 2019). Thus, the lack of observation of activity at the crude extracts does not exclude the hypothesis of the isolation compounds of this species present such activity.…”

“…The few studies found showed that crude extracts and their isolated compounds from several species of genus Miconia sp. have shown biological activities with promising results, such as antioxidant (Gontijo et al, 2019), anti-Trypanosoma (Cunha et al, 2006); anti-Leishmania (Peixoto et al, 2011;Viegas et al, 2019); antibiotic (Alves et al, 2008;Rodrigues et al, 2008;Gontijo et al, 2019;Viegas et al, 2019), analgesic, anti-inflammatory (Vasconcelos et Brazilian Journal of Development, Curitiba, v.7, n.4, p. 37798-37819 apr 2021 Gatis-Carrazzoni et al, 2018) and antitumor (Li et al, 2002;Cunha et al, 2008;Serpeloni et al, 2008).…”

Flavanone Glycosides, Triterpenes, Volatile Compounds and Antimicrobial Activity of Miconia minutiflora (Bonpl.) DC. (Melastomataceae)

“…The ethanolic leaf extract of M. albicans shows an anti-arthritic profile [ 7 ]. The ethanolic extract of M. willdenowii Klotzsch ex Naudin showed schistosomicidal [ 8 ], antimicrobial activities, and anti- L. amazonensis effects, as well as evidence that the most abundant constituent, the benzoquinone derivative primin, is the major bioactive metabolite [ 9 ].…”