Leishmanicidal activity of polyphenolic-rich extract from husk fiber of Cocos nucifera Linn. (Palmae)

Mendonça-Filho, Ricardo R.; Rodrigues, Igor A.; Alviano, Daniela Sales; Santos, André Luis Souza dos; Soares, R. Félix; Alviano, Celuta Sales; Lopes, Angela H.; Rosa, Maria do Socorro S.

doi:10.1016/j.resmic.2003.12.001

Cited by 91 publications

(59 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Alviano et al (2004), detected analgesic and free radical scavenging properties in the aqueous extract of stem bark fibers. In addition, we also detected effects such as leishmanicide, antioxidant and antiviral (Mendonça et al, 2004;Kirszberg et al, 2003;Esquenazi et al, 2002) when analyzing the same extract. The Attalea phalerata (acuri) is a palm tree from the Pantanal region known as "acurizais" (Pott & Pott, 1994).…”

Section: In Vitro Cytotoxic Activity Of Brazilian Middle West Plant Ementioning

confidence: 99%

In vitro cytotoxic activity of Brazilian Middle West plant extracts

Mahmoud¹,

Marques²,

Pessoa³

et al. 2011

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Cytotoxic activity of eight plant extracts, native from the MidWest of Brazil comprising Cerrado, Pantanal and semideciduous forest, was evaluated for MDA-MB-435, SF-295, and HCT-8 cancer cell strains. A single 100 µg.mL -1 dose of each extract was employed with 72 h of incubation for all tests. Doxorubicin (1 µg.mL -1 ) was used as the positive control and the MTT method was used to detect the activity. Cytotoxicity of distinct polarities was observed in thirty extracts (46%), from different parts of the following species: Tabebuia heptaphylla (Vell.) Toledo, Bignoniaceae, Tapirira guianensis Aubl., Anacardiaceae, Myracrodruon urundeuva Allemão, Anacardiaceae, Schinus terebinthifolius Raddi, Anacardiaceae, Gomphrena elegans Mart., Amaranthaceae, Attalea phalerata Mart. ex Spreng., Arecaceae, Eugenia uniflora L., Myrtaceae, and Annona dioica A. St.-Hil., Annonaceae. Extracts of at least two tested cell strains were considered to be highly active since their inhibition rate was over 75%.

show abstract

Section: In Vitro Cytotoxic Activity Of Brazilian Middle West Plant Ementioning

confidence: 99%

In vitro cytotoxic activity of Brazilian Middle West plant extracts

Mahmoud¹,

Marques²,

Pessoa³

et al. 2011

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…It has also been reported to have antibacterial, antiviral, antidysenteric, antifungal, antileishmanial, antilymphoproliferative and antineoplasic activities (Esquenazi et al, 2002;Mendonca-Filho et al, 2004;Kirszberg et al, 2003;Koschek et al, 2007). Moumita and Adinpunya (2007) observed that the husks of the coconut palm are discarded as waste and it is considered as one of the major agro wastes of the tropical countries, hence this study will definitely open up a scope for the future utilization of these agro waste for therapeutic purposes.…”

Section: Introductionmentioning

confidence: 84%

In vitro antilisterial properties of crude aqueous and n-hexane extracts of the husk of Cocos nucifera

Akinyele¹,

T²,

Akinpelu³

et al. 2011

Afr. J. Biotechnol.

View full text Add to dashboard Cite

The in vitro antilisterial activities and time kill regimes of crude aqueous and n-hexane extracts of the husk fiber of Cocos nucifera were assessed. The aqueous extracts were active against 29 of the 37 test Listeria isolates while the n-hexane extracts were active against 30. The minimum inhibitory concentrations (MICs) of all the susceptible bacteria ranged between 0.6 and 2.5 mg/ml for the aqueous fraction and between 0.6 and 5.0 mg/ml for the n-hexane extract. The average log reduction in viable cell count in the time kill assay ranged between 0.32 Log 10 and 3.2 Log 10 cfu/ml after 4 h of interaction, and between 2.6 Log 10 and 4.8 Log 10 cfu/ml after 8 h interaction in 1 × MIC and 2 × MIC (aqueous extract); and between 2.8 Log 10 and 4.8 Log 10 cfu/ml after 4 h of interaction, and 3.5 Log 10 to 6.2 Log 10 cfu/ml after 8 h interaction in 1 × MIC and 2 × MIC for the n-hexane extract. The extract was bactericidal against one of the test bacteria at 1 × MIC and against three of the test bacteria at 2 × MIC for the 8 h interaction period for the aqueous extract, while for the n-Hexane fraction; the extract was bactericidal against all the five test bacteria at both MICs after the 8 h interaction period. We suggested that the crude aqueous and n-hexane extracts of the husk of C. nucifera could be bacteriostatic or bactericidal depending on the time of exposure and concentration.

show abstract

“…The liquid obtained from the husk fiber has antiproliferative (Kirszberg et al, 2003), antioxidant and analgesic activities . Fractions of this liquid obtained with ethyl acetate solvent showed antibacterial, antiviral (Esquenazi et al, 2002) and leishmanicidal activities (Mendonça-Filho et al, 2004).…”

Section: Introductionmentioning

confidence: 97%

“…This infection has a broad clinical spectrum, ranging from subclinical disease to cutaneous and/or visceral infections, causing high morbidity and mortality. Leishmania braziliensis is one of the main agents of cutaneous leishmaniasis, which is usually unresponsive to treatment known (Mendonça-Filho et al, 2004). Many mammals, such as canines (Gramiccia & Gradoni, 2005) and felines (Simões-Mattos et al, 2005), may serve as reservoir and may develop the disease caused by L. braziliensis.…”

Section: Introductionmentioning

confidence: 99%

Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters

Freitas¹,

Nunes-Pinheiro²,

Pessoa³

et al. 2011

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Abstract:The objective of this study was to evaluate the treatment with ethyl acetate extract (EAE) from husk fiber water of Cocos nucifera L., Arecaceae, in L. braziliensis (Lb) infected hamsters. Twelve male hamsters were randomly allocated in three groups (n=4): G1 received only EAE; G2 was infected with Lb only and G3 received EAE after Lb infection. The infection was carried 28 days prior to the treatment with EAE, which was administrated (0.2 mL, 300 mg.kg -1 ) for 21 consecutive days. Infection was evaluated through skin lesions and infected footpad edema. Haematological evaluation was done on -28 th , 0 and 21 st days. Imprint footpad and lymph node weight were evaluated on 21 st day. Lb infection significantly inhibited the peripheral leukocytes blood. However, neutrophils and lymphocytes values did not have significant alterations. G3 presented eosinophilia in relation to G2. The treatment with EAE did not reduce edema of infected footpad neither weight of drainage lymph node. Infected footpad imprints revealed amastigotes forms and cellular infiltration. Animals from G3 presented skin lesions on 7 th day, shown a reduction of these lesions in day 14. Therefore, the treatment with EAE did not alter the etiological agent elimination in these conditions. However, EAE presents a healing activity in this experimental model.

show abstract

Leishmanicidal activity of polyphenolic-rich extract from husk fiber of Cocos nucifera Linn. (Palmae)

Cited by 91 publications

References 34 publications

In vitro cytotoxic activity of Brazilian Middle West plant extracts

In vitro cytotoxic activity of Brazilian Middle West plant extracts

In vitro antilisterial properties of crude aqueous and n-hexane extracts of the husk of Cocos nucifera

Effect of ethyl acetate extract from husk fiber water of Cocos nucifera in Leishmania braziliensis infected hamsters

Contact Info

Product

Resources

About