Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract

Abstract

SUMMARYIn this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC 50 values of 62.9 and 37.5 μg.mL -1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.

The efficacy of 2-nitrovinylfuran derivatives againstLeishmania in vitro and in vivo

“…Although responses to the test compounds and AmPB were demonstrated, a complete clinical cure was not achieved. This partial efficacy of AmPB has been reported ( Al-Abdely et al 1999 , Parra et al 2010 ) and has been associated with the high multiplication rate of parasites at the site of infection ( Fuchino et al 2008 ).…”

Utilização da nanoemulsão lipídica no tratamento experimental da leishmaniose cutânea

“…-Abdely et al. 1999;Parra et al, 2010) e associada com alta taxa de multiplicação de parasitos no local da infecção (Fuchino et al, 2008). Santos et al (2018) relataram toxicidade aguda quando a dose de 2 mg/kg da formulação convencional de AB foi administrada, causando a morte de vários animais e, portanto, este estudo foi interrompido.…”